2,4-Dichloro-5-pyrimidinecarbonyl chloride
- CAS No.
- 2972-52-3
- Chemical Name:
- 2,4-Dichloro-5-pyrimidinecarbonyl chloride
- Synonyms
- 2,4-Dichloropyrimidine-5-carbonyl chloride;2,4-Dichloro-5-pyrimidinecarboxylic acid chloride;RSYY（Avanafil)-46;5-(Chlorocarbonyl)-2,4-dichlo;2,4-dichloro-5-pyrimidinyl chloride;2,4-Dichloro-5-pyrimidinecarbonylchloride;5-(Chlorocarbonyl)-2,4-dichloropyrimidine;2,3-Dichloro-5-pyrimidine carbonyl chloride;5-Pyrimidinecarbonyl chloride, 2,4-dichloro-;2,4-DichloropyriMidine-5-carbonyl chloride 97%
- CBNumber:
- CB7956663
- Molecular Formula:
- C5HCl3N2O
- Molecular Weight:
- 211.43
- MDL Number:
- MFCD09742432
- MOL File:
- 2972-52-3.mol
- MSDS File:
- SDS
| Boiling point | 83 °C(Press: 0.05 Torr) |
|---|---|
| Density | 1.645 g/mL at 25 °C |
| refractive index | n20/D1.586 |
| Flash point | 93℃ |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| form | liquid |
| pka | -5.08±0.29(Predicted) |
| color | Clear, colourless |
| InChI | InChI=1S/C5HCl3N2O/c6-3-2(4(7)11)1-9-5(8)10-3/h1H |
| InChIKey | DZTIFMWYYHCREC-UHFFFAOYSA-N |
| SMILES | C(Cl)(C1=CN=C(Cl)N=C1Cl)=O |
| CAS DataBase Reference | 2972-52-3(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302+H312+H332-H314 |
| Precautionary statements | P261-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | C,Xi |
| Risk Statements | 20/21/22-34 |
| Safety Statements | 6-7/9-24/25-26-36/37/39-51 |
| RIDADR | 3265 |
| WGK Germany | 3 |
| HazardClass | IRRITANT, CORROSIVE |
| PackingGroup | Ⅲ |
| HS Code | 2933599590 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Dam. 1 Skin Corr. 1B |
2,4-Dichloro-5-pyrimidinecarbonyl chloride price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 728772 | 2,4-Dichloropyrimidine-5-carbonyl chloride 97% | 2972-52-3 | 500mg | $99.4 | 2026-04-30 | Buy |
| Usbiological | 270845 | 2,3-Dichloro-5-pyrimidine carbonyl chloride Asreported | 2972-52-3 | 1g | $433 | 2026-06-03 | Buy |
| Usbiological | 270845 | 2,3-Dichloro-5-pyrimidine carbonyl chloride Asreported | 2972-52-3 | 2g | $616 | 2026-06-03 | Buy |
| Usbiological | 270845 | 2,3-Dichloro-5-pyrimidine carbonyl chloride Asreported | 2972-52-3 | 5g | $984 | 2026-06-03 | Buy |
| Usbiological | 270845 | 2,3-Dichloro-5-pyrimidine carbonyl chloride Asreported | 2972-52-3 | 10g | $1500 | 2026-06-03 | Buy |
2,4-Dichloro-5-pyrimidinecarbonyl chloride Chemical Properties,Uses,Production
Synthesis
23945-44-0
2972-52-3
The general procedure for the synthesis of 2,4-dichloro-5-pyrimidinecarbonyl chloride from uracil-5-carboxylic acid is as follows: 9.1 Preparation of 2,4-dihydroxypyrimidine-5-carbonyl chloride In a 250 mL round bottom flask, 10.0 g (64.0 mmol) of 2,4-dihydroxypyrimidine-5-carboxylic acid was dissolved in 46 mL (500.0 mmol) of phosphorus oxychloride (POCl3) under nitrogen protection. The reaction mixture was cooled to 0°C via an ice bath, followed by the batch addition of 47.7 g (230 mmol) phosphorus pentachloride (PCl5). The reaction solution was heated and stirred at reflux for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in 100 mL of toluene and ground, followed by filtration. After this operation was repeated three times, the filtrate was evaporated under reduced pressure to give 13.5 g (64.0 mmol) of the yellow oily product 2,4-dichloro-5-pyrimidinecarbonyl chloride, which was used directly in the next step of the reaction. Yield = 100%.
References
[1] Patent: US2011/251194, 2011, A1. Location in patent: Page/Page column 21
[2] Patent: US2010/222319, 2010, A1. Location in patent: Page/Page column 18
[3] Patent: WO2015/21149, 2015, A1. Location in patent: Page/Page column 56; 57
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 6, p. 2746 - 2763
[5] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 55
2,4-Dichloro-5-pyrimidinecarbonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai civi chemical technology co.,Ltd | 86-21-34053660 | sale@labgogo.com | China | 9853 | 52 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
View Lastest Price from 2,4-Dichloro-5-pyrimidinecarbonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-31 | 2,4-Dichloro-5-pyrimidinecarbonyl chloride
2972-52-3
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- 2,4-Dichloro-5-pyrimidinecarbonyl chloride
2972-52-3
- $1.00
- 95-99%
- Career Henan Chemical Co
