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ChemicalBook >> CAS DataBase List >>2-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo-, ethyl ester, compd. with N-methylmethanamine (1:1)

2-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo-, ethyl ester, compd. with N-methylmethanamine (1:1)

2-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo-, ethyl ester, compd. with N-methylmethanamine (1:1) Structure
2-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo-, ethyl ester, compd. with N-methylmethanamine (1:1) structure
CAS No.
2428387-48-6
Chemical Name:
2-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo-, ethyl ester, compd. with N-methylmethanamine (1:1)
Synonyms
COX-2-IN-14;2-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo-, ethyl ester, compd. with N-methylmethanamine (1:1)
CBNumber:
CB613223876
Molecular Formula:
C18H18N4O6
Molecular Weight:
386.36
MDL Number:
MOL File:
2428387-48-6.mol
MSDS File:
SDS
Last updated:2026-04-20 17:00:22
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2-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo-, ethyl ester, compd. with N-methylmethanamine (1:1) Chemical Properties, Uses, Production

Uses

COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice[1].

IC 50

COX-2

References

[1] Gonalves DS, et al. Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity. Bioorg Med Chem. 2020 Jun 15;28(12):115549. DOI:10.1016/j.bmc.2020.115549

2-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo-, ethyl ester, compd. with N-methylmethanamine (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

2-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo-, ethyl ester, compd. with N-methylmethanamine (1:1) Suppliers

Global Suppliers ( 2)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 2-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo-, ethyl ester, compd. with N-methylmethanamine (1:1) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
COX-2-IN-14 pictures 2026-04-20 COX-2-IN-14
2428387-48-6
 $1520.00-2500.00 10g TargetMol Chemicals Inc.
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  • COX-2-IN-14
    2428387-48-6
  • $1520.00-2500.00
  • TargetMol Chemicals Inc.

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2-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo-, ethyl ester, compd. with N-methylmethanamine (1:1) COX-2-IN-14 2428387-48-6