IS 741
- CAS No.
- 141283-87-6
- Chemical Name:
- IS 741
- Synonyms
- Fuzapladib;IS 741;IS-741 (Fuzapladib;Fuzapladib （IS-741）;Fuzapladib, 10 mM in DMSO;N-(2-(Ethylsulfonamido)-5-(trifluoromethyl)pyridin-3-yl)cyclohexanecarboxamide;Cyclohexanecarboxamide, N-[2-[(ethylsulfonyl)amino]-5-(trifluoromethyl)-3-pyridinyl]-
- CBNumber:
- CB61364116
- Molecular Formula:
- C15H20F3N3O3S
- Molecular Weight:
- 379.4
- MDL Number:
- MOL File:
- 141283-87-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.411±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | -10 to -25°C |
| solubility | DMSO: 2mg/mL, clear |
| pka | 5.41±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| InChI | InChI=1S/C15H20F3N3O3S/c1-2-25(23,24)21-13-12(8-11(9-19-13)15(16,17)18)20-14(22)10-6-4-3-5-7-10/h8-10H,2-7H2,1H3,(H,19,21)(H,20,22) |
| InChIKey | TUWCZRFHNIOVTC-UHFFFAOYSA-N |
| SMILES | C1(C(NC2=CC(C(F)(F)F)=CN=C2NS(CC)(=O)=O)=O)CCCCC1 |
| FDA UNII | 03TE67E8IR |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
IS 741 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0014891 | Fuzapladib 98.75% | 141283-87-6 | 5mg | $238 | 2026-06-04 | Buy |
| ChemScene | CS-0014891 | Fuzapladib 98.75% | 141283-87-6 | 10mg | $357 | 2026-06-04 | Buy |
| ChemScene | CS-0014891 | Fuzapladib 98.75% | 141283-87-6 | 25mg | $672 | 2026-06-04 | Buy |
| ChemScene | CS-0014891 | Fuzapladib 98.75% | 141283-87-6 | 50mg | $899 | 2026-06-04 | Buy |
| ChemScene | CS-0014891 | Fuzapladib 98.75% | 141283-87-6 | 100mg | $1192 | 2026-06-04 | Buy |
IS 741 Chemical Properties, Uses, Production
Uses
Fuzapladib (IS-741), an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site[1][2].
Biological Activity
Fuzapladib (IS-741) is a cell penetrant and potent phospholipase A2 (PLA2) inhibitor. Fuzapladib decelerate the progression of pancreatic fibrosis through monocyte infiltration in dogs.
in vivo
Fuzapladib (IS-741) (p.o., 50 mg/kg, 7 days) inhibits neutrophil infiltration into inflamed lesions, and is effective for attenuating rat trinitrobenzene sulfonic acid (TNBS) ileitis[4].
| Animal Model: | Rats[4] |
| Dosage: | 50 mg/kg |
| Administration: | P.o.; for 7 days |
| Result: | Significantly reduced myeloperoxidase (MPO) activity and mucosal IL-8 levels in rat ileum, reduced polymorphonuclear cells and Mac-1 positivity Infiltration of cells into inflammatory lesions, effectively alleviated trinitrobenzenesulfonic acid (TNBS)-induced ileitis. |
References
[1] Noriyuki Kaji, et al. Fuzapladib reduces postsurgical inflammation in the intestinal muscularis externa. J Vet Med Sci. 2023 Sep 21. DOI:10.1292/jvms.23-0257
[2] C Bassi. IS-741 (Ishihara Sangyo). Curr Opin Investig Drugs. 2001 Apr;2(4):510-2. PMID:11566008
[3] Shikama H, et al. Effect of IS-741 on cell adhesion between human umbilical vein endothelial cells and HL-60 cells. Biol Pharm Bull. 1999 Feb;22(2):127-31. DOI:10.1248/bpb.22.127
[4] Tetsuya Fukunaga, et al. A novel diamino-pyridine derivative (IS-741) attenuates rat ileitis induced by trinitrobenzene sulfonic acid. J Gastroenterol. 2003;38(5):451-9. DOI:10.1007/s00535-002-1081-8
IS 741 Preparation Products And Raw materials
Raw materials
Preparation Products
IS 741 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Xinyitai Pharmaceutical Technology Development Co. | 010-010-67806114 13260355681 | micsunstar@sina.com | China | 32 | 58 |
| Hubei widely chemical technology Co., Ltd. | 17771478861 13419635609 | 3525818213@qq.com | China | 1887 | 55 |
| Chongqing Xinboyao Biological Technology Co., LTD | 19122915778 | 1549869036@qq.com | China | 500 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Wellman Pharmaceutical Group Limited | 15807197853 18971451745 | 15807197853@163.com | China | 3977 | 58 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13774476675 | sales@fdc-chemical.com | China | 10000 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Hubei Weideli Chemical Reagent Co., Ltd. | 13429867250 13429867250 | w13429867250@163.com | China | 1923 | 58 |
| Hubei Weideli Chemical Reagent Co., Ltd. | 18327179646 | 18327179646@163.com | China | 1980 | 58 |
View Latest Price from IS 741 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Fuzapladib
141283-87-6
|
$35.00-133.00 | 99.87% | 10g | TargetMol Chemicals Inc. |
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- Fuzapladib
141283-87-6
- $35.00-133.00
- 99.87%
- TargetMol Chemicals Inc.
