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2-Bromo-3-cyanopyridine

2-Bromo-3-cyanopyridine structure

CAS No.: 20577-26-8

Chemical Name:: 2-Bromo-3-cyanopyridine

Synonyms: 2-Bromo-3-cyanopyridine;2-BROMOPYRIDINE-3-CARBONITRILE;IFLAB-BB F1957-0002;2-BroMo-nicotionitrile;2-broMo-3-cyanopyridin;2-BROMO-NICOTINONITRILE;2-Bromonicotinonitrile 98%;2-Bromo-3-cyanopyridine,98%;2-Bromo-3-pyridinecarbonitrile;3-Pyridinecarbonitrile,2-broMo-

CBNumber:: CB6137362

Molecular Formula:: C6H3BrN2

Molecular Weight:: 183.01

MDL Number:: MFCD00234140

MOL File:: 20577-26-8.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:51

Product description	Number	Pack Size	Price
2-Bromo-3-cyanopyridine	B682828	1g	$75
2-Bromonicotinonitrile	3H37-9-Z8	1g	$90
2-Bromo-3-cyanopyridine 95+%	072104	5g	$99
2-Bromo-3-cyanopyridine	FB12363	2g	$630
2-Bromo-3-cyanopyridine 95+%	072104	25g	$358
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2-Bromo-3-cyanopyridine Properties

Melting point	105 °C
Boiling point	296.9±25.0 °C(Predicted)
Density	1.72±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	Solid
pka	-2.66±0.10(Predicted)
Appearance	White to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H312-H315-H319-H332-H335

Precautionary statements

P261-P280-P304+P340-P305+P351+P338-P405-P501a

HazardClass

6.1

HS Code

2933399990

NFPA 704

	1
2		0

2-Bromo-3-cyanopyridine price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B682828	2-Bromo-3-cyanopyridine	20577-26-8	1g	$75	2021-12-16	Buy
SynQuest Laboratories	3H37-9-Z8	2-Bromonicotinonitrile	20577-26-8	1g	$90	2021-12-16	Buy
Matrix Scientific	072104	2-Bromo-3-cyanopyridine 95+%	20577-26-8	5g	$99	2021-12-16	Buy
Biosynth Carbosynth	FB12363	2-Bromo-3-cyanopyridine	20577-26-8	2g	$630	2021-12-16	Buy
Matrix Scientific	072104	2-Bromo-3-cyanopyridine 95+%	20577-26-8	25g	$358	2021-12-16	Buy

Product number	Packaging	Price	Buy
B682828	1g	$75	Buy
3H37-9-Z8	1g	$90	Buy
072104	5g	$99	Buy
FB12363	2g	$630	Buy
072104	25g	$358	Buy

2-Bromo-3-cyanopyridine Chemical Properties,Uses,Production

Synthesis

20577-27-9

20577-26-8

General procedure for the synthesis of 2-bromo-3-cyanopyridine from 2-oxo-1,2-dihydropyridine-3-carbonitrile: First, 2-chloro-3-cyanopyridine (3.68 mg, 26 mmol) was refluxed in acetic acid (100 mL) for 12 hours. After completion of the reaction, the evaporated residue was dissolved in a solvent mixture of tetrahydrofuran (80 mL) and water (20 mL) and refluxed for 4 hours. Evaporation of the solvent gave 3-cyanopyridin-2-one (3.12 g, quantitative yield) as white crystals with a melting point of 110-114 °C (literature value 13174-175 °C). Its nuclear magnetic resonance hydrogen spectrum (1H NMR) showed δ 6.47 (1H, t, J = 6.6 Hz, 5-H), 7.91 (1H, dd, J = 6.5, 2.1 Hz, 4-H), 8.14 (1H, dd, J = 7.0, 2.1 Hz, 6-H), and 11.48 (1H, s, 1-H); and nuclear magnetic resonance carbon spectrum (13C NMR) showed δ 105.80 (3-C), 124.05 (5-C), 141.87 (CN), 144.50 (6-H), 150.02 (4-C), 154.20 (2-C); mass spectrum (MS) m/z 143.0214 (M + Na)+ (calculated value C6H4N2NaO 143.0222). Next, tetrabutylammonium bromide (Bu4NBr, 8.55 g, 26 mmol) and phosphorus pentoxide (P2O5, 3.67 g, 26 mmol) were heated in toluene (250 mL) at 80 °C for 30 min. Then 3-cyanopyridin-2-one (1.59 g, 13 mmol) prepared above was added and the mixture was refluxed for 12 hours. After completion of the reaction, the mixture was cooled, poured into cold water and extracted twice with ethyl acetate. The organic layers were combined, dried and the solvent was evaporated to give 2-bromo-3-cyanopyridine (2.24 g, 94% yield) as white crystals with a melting point of 114-118 °C (literature values 14 °C, 105 °C). Infrared spectra (IR) showed νmax 2236, 1574, 1550, 1472 cm-1 ; nuclear magnetic resonance hydrogen spectra (1H NMR, CDCl3) showed δ 7.42 (1H, dd, J = 7.7, 4.8 Hz, 5-H), 8.01 (1H, dd, J = 7.8, 2.0 Hz, 4-H), 8.57 (1H, dd, J = 4.9, 2.0 Hz, 6-H); nuclear magnetic resonance carbon spectrum (13C NMR) showed δ 114.27 (3-C), 115.63 (CN), 122.37 (5-C), 142.53 (4-C), 143.84 (2-C), 152.92 (6-C).

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3013 - 3032

2-Bromo-3-cyanopyridine Preparation Products And Raw materials

Raw materials

2-Hydroxy-3-cyanopyridine Toluene TETRABUTYLAMMOMIUM BROMIDE Phosphorus pentoxide

Preparation Products

2-pyrrolidin-1-ylnicotinonitrile

2-Bromo-3-cyanopyridine Suppliers

Global( 122)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Nanjing Fred Technology Co., Ltd.	+86-02584696168 15380713688	Austin@fredchem.cn	CHINA	865	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	10000	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8645	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Alchem Pharmtech,Inc.	58
Antai Fine Chemical Technology Co.,Limited	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Nanjing Fred Technology Co., Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Shaanxi Dideu Medichem Co. Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
CR Corporation Limited	58

View Lastest Price from 2-Bromo-3-cyanopyridine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-06-25	2-BROMO-NICOTINONITRILE 20577-26-8	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	2-BROMO-NICOTINONITRILE 20577-26-8	US $3.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

2-BROMO-NICOTINONITRILE
20577-26-8
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

2-BROMO-NICOTINONITRILE
20577-26-8
US $3.00 / KG
99%
Career Henan Chemical Co

2-Bromo-3-cyanopyridine Spectrum

2-Bromo-3-cyanopyridine(20577-26-8)¹HNMR

20577-26-8(2-Bromo-3-cyanopyridine)Related Search:

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2-BROMOPYRIDINE-3-CARBONITRILE 2-BROMO-NICOTINONITRILE IFLAB-BB F1957-0002 2-bromonicotinonitrile(SALTDATA: FREE) 2-broMo-3-cyanopyridin 3-Pyridinecarbonitrile,2-broMo- 2-BroMo-nicotionitrile 2-Bromo-3-pyridinecarbonitrile 2-Bromopyridine-3-carbonitrile, 2-Bromo-3-cyanopyridine 2-Bromonicotinonitrile 98% 2-Bromo-3-cyanopyridine,98% 2-BROMO-NICOTINONITRILE ISO 9001：2015 REACH 2-Bromo-3-cyanopyridine 20577-26-8 Heterocycle-Pyridine series cyanide| alkyl bromide pyridine