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2-Bromo-3-cyanopyridine

2-Bromo-3-cyanopyridine structure

CAS No.: 20577-26-8

Chemical Name:: 2-Bromo-3-cyanopyridine

Synonyms: 2-Bromo-3-cyanopyridine;2-BROMOPYRIDINE-3-CARBONITRILE;IFLAB-BB F1957-0002;2-BroMo-nicotionitrile;2-broMo-3-cyanopyridin;2-BROMO-NICOTINONITRILE;2-Bromonicotinonitrile 98%;2-Bromo-3-cyanopyridine,98%;2-Bromo-3-pyridinecarbonitrile;3-Pyridinecarbonitrile,2-broMo-

CBNumber:: CB6137362

Molecular Formula:: C6H3BrN2

Molecular Weight:: 183.01

MDL Number:: MFCD00234140

MOL File:: 20577-26-8.mol

MSDS File:: SDS

Last updated:2026-05-28 01:21:11

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2-Bromo-3-cyanopyridine Properties

Melting point	105 °C
Boiling point	296.9±25.0 °C(Predicted)
Density	1.72±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	Solid
pka	-2.66±0.10(Predicted)
Appearance	White to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H312-H315-H319-H332-H335

Precautionary statements

P261-P280-P304+P340-P305+P351+P338-P405-P501a

HazardClass

6.1

HS Code

2933399990

NFPA 704

	1
2		0

2-Bromo-3-cyanopyridine price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	261982	2-Bromo-3-cyanopyridine Asreported	20577-26-8	1g	$768	2026-06-03	Buy
Usbiological	261982	2-Bromo-3-cyanopyridine Asreported	20577-26-8	2g	$1210	2026-06-03	Buy
Usbiological	261982	2-Bromo-3-cyanopyridine Asreported	20577-26-8	5g	$2248	2026-06-03	Buy
Usbiological	261982	2-Bromo-3-cyanopyridine Asreported	20577-26-8	10g	$3433	2026-06-03	Buy
Usbiological	261982	2-Bromo-3-cyanopyridine Asreported	20577-26-8	25g	$6105	2026-06-03	Buy

Product number	Packaging	Price	Buy
261982	1g	$768	Buy
261982	2g	$1210	Buy
261982	5g	$2248	Buy
261982	10g	$3433	Buy
261982	25g	$6105	Buy

2-Bromo-3-cyanopyridine Chemical Properties, Uses, Production

Synthesis

20577-27-9

20577-26-8

General procedure for the synthesis of 2-bromo-3-cyanopyridine from 2-oxo-1,2-dihydropyridine-3-carbonitrile: First, 2-chloro-3-cyanopyridine (3.68 mg, 26 mmol) was refluxed in acetic acid (100 mL) for 12 hours. After completion of the reaction, the evaporated residue was dissolved in a solvent mixture of tetrahydrofuran (80 mL) and water (20 mL) and refluxed for 4 hours. Evaporation of the solvent gave 3-cyanopyridin-2-one (3.12 g, quantitative yield) as white crystals with a melting point of 110-114 °C (literature value 13174-175 °C). Its nuclear magnetic resonance hydrogen spectrum (1H NMR) showed δ 6.47 (1H, t, J = 6.6 Hz, 5-H), 7.91 (1H, dd, J = 6.5, 2.1 Hz, 4-H), 8.14 (1H, dd, J = 7.0, 2.1 Hz, 6-H), and 11.48 (1H, s, 1-H); and nuclear magnetic resonance carbon spectrum (13C NMR) showed δ 105.80 (3-C), 124.05 (5-C), 141.87 (CN), 144.50 (6-H), 150.02 (4-C), 154.20 (2-C); mass spectrum (MS) m/z 143.0214 (M + Na)+ (calculated value C6H4N2NaO 143.0222). Next, tetrabutylammonium bromide (Bu4NBr, 8.55 g, 26 mmol) and phosphorus pentoxide (P2O5, 3.67 g, 26 mmol) were heated in toluene (250 mL) at 80 °C for 30 min. Then 3-cyanopyridin-2-one (1.59 g, 13 mmol) prepared above was added and the mixture was refluxed for 12 hours. After completion of the reaction, the mixture was cooled, poured into cold water and extracted twice with ethyl acetate. The organic layers were combined, dried and the solvent was evaporated to give 2-bromo-3-cyanopyridine (2.24 g, 94% yield) as white crystals with a melting point of 114-118 °C (literature values 14 °C, 105 °C). Infrared spectra (IR) showed νmax 2236, 1574, 1550, 1472 cm-1 ; nuclear magnetic resonance hydrogen spectra (1H NMR, CDCl3) showed δ 7.42 (1H, dd, J = 7.7, 4.8 Hz, 5-H), 8.01 (1H, dd, J = 7.8, 2.0 Hz, 4-H), 8.57 (1H, dd, J = 4.9, 2.0 Hz, 6-H); nuclear magnetic resonance carbon spectrum (13C NMR) showed δ 114.27 (3-C), 115.63 (CN), 122.37 (5-C), 142.53 (4-C), 143.84 (2-C), 152.92 (6-C).

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3013 - 3032

2-Bromo-3-cyanopyridine Preparation Products And Raw materials

Raw materials

2-Hydroxy-3-cyanopyridine Toluene Tetrabutylammomium bromide Phosphorus pentoxide

Preparation Products

2-pyrrolidin-1-ylnicotinonitrile

2-Bromo-3-cyanopyridine Suppliers

Global Suppliers ( 122)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57
Shanghai Cuisen Pharmaceutical Technology Co., Ltd.	13472757003	yongnan.wang@cendrix.cn	China	974	65
China Langchem Inc.	0086-21-58956006		China	7798	57

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Energy Chemical	61
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Shandong Xiya Chemical Co., Ltd	57
Shanghai Cuisen Pharmaceutical Technology Co., Ltd.	65
China Langchem Inc.	57

View Latest Price from 2-Bromo-3-cyanopyridine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-06-25	2-BROMO-NICOTINONITRILE 20577-26-8	$1.10	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	2-BROMO-NICOTINONITRILE 20577-26-8	$3.00	1KG	99%	100kg	Career Henan Chemical Co

2-BROMO-NICOTINONITRILE
20577-26-8
$1.10
99.0% min
Shaanxi Dideu Medichem Co. Ltd

2-BROMO-NICOTINONITRILE
20577-26-8
$3.00
99%
Career Henan Chemical Co

2-Bromo-3-cyanopyridine Spectrum

2-Bromo-3-cyanopyridine(20577-26-8)¹HNMR

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2-BROMOPYRIDINE-3-CARBONITRILE 2-BROMO-NICOTINONITRILE IFLAB-BB F1957-0002 2-bromonicotinonitrile(SALTDATA: FREE) 2-broMo-3-cyanopyridin 3-Pyridinecarbonitrile,2-broMo- 2-BroMo-nicotionitrile 2-Bromo-3-pyridinecarbonitrile 2-Bromopyridine-3-carbonitrile, 2-Bromo-3-cyanopyridine 2-Bromonicotinonitrile 98% 2-Bromo-3-cyanopyridine,98% 2-BROMO-NICOTINONITRILE ISO 9001：2015 REACH 2-Bromo-3-cyanopyridine 20577-26-8 Heterocycle-Pyridine series cyanide| alkyl bromide pyridine