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2,5-Dibromo-4-methylpyridine

2,5-Dibromo-4-methylpyridine Structure
2,5-Dibromo-4-methylpyridine structure
CAS No.
3430-26-0
Chemical Name:
2,5-Dibromo-4-methylpyridine
Synonyms
2,3-dibromo-4-methylpyridine;TIMTEC-BB SBB003142;2,5-Dibromo-4-methyL;2,5-DIBROMO-4-PICOLINE;3-Chloro-3-iodopyridine;2,5-Dibromo-4-picoline,98%;2,5-DIBROMO-4-METHYLPYRIDINE;Pyridine, 2,5-dibromo-4-methyl-;2,5-Dibromo-4-methylpyridine >2,5-Dibromo-4-methylpyridine, 97%
CBNumber:
CB6140119
Molecular Formula:
C6H5Br2N
Molecular Weight:
250.92
MDL Number:
MFCD00234955
MOL File:
3430-26-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:49:00
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2,5-Dibromo-4-methylpyridine Properties

Melting point 37-42 °C
Boiling point 181.5°C (rough estimate)
Density 1.9318 (rough estimate)
refractive index 1.6300 (estimate)
Flash point 113°
storage temp. Inert atmosphere,Room Temperature
solubility soluble in Methanol
pka -0.91±0.18(Predicted)
form Low Melting Solid
color Light yellow to orange
InChI InChI=1S/C6H5Br2N/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3
InChIKey WWJLJUAHQHXDGM-UHFFFAOYSA-N
SMILES C1(Br)=NC=C(Br)C(C)=C1
CAS DataBase Reference 3430-26-0(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-20/21/22-41-37/38-22
Safety Statements  36/37/39-26-39
WGK Germany  3
Hazard Note  Harmful
HazardClass  IRRITANT
HS Code  29333999
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2,5-Dibromo-4-methylpyridine price More Price(82)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 708143 2,5-Dibromo-4-methylpyridine 97% 3430-26-0 1g $64.7 2023-06-20 Buy
TCI Chemical D4058 2,5-Dibromo-4-methylpyridine >98.0%(GC) 3430-26-0 1g $28 2026-04-30 Buy
TCI Chemical D4058 2,5-Dibromo-4-methylpyridine >98.0%(GC) 3430-26-0 5g $71 2026-04-30 Buy
Usbiological 230952 2,5-Dibromo-4-methylpyridine 98+% 98% 3430-26-0 1g $163 2026-06-03 Buy
Usbiological 230952 2,5-Dibromo-4-methylpyridine 98+% 98% 3430-26-0 5g $215 2026-06-03 Buy
Product number Packaging Price Buy
708143 1g $64.7 Buy
D4058 1g $28 Buy
D4058 5g $71 Buy
230952 1g $163 Buy
230952 5g $215 Buy

2,5-Dibromo-4-methylpyridine Chemical Properties,Uses,Production

Uses

2,5-Dibromo-4-methylpyridine is mainly used in organic synthesis, and in the pharmaceutical industry, it is used to synthesize heart disease drugs such as disopyramide (disopyramide phosphate). Disopyramide is used to maintain sinus rhythm in atrial fibrillation and atrial flutter, or to prevent the recurrence of ventricular tachycardia and ventricular fibrillation. It can also be used for premature atrial contractions, paroxysmal atrial tachycardia, premature ventricular contractions, etc.

Chemical Properties

Light yellow to orange low melting solid

Synthesis

2-Amino-5-bromo-4-methylpyridine

98198-48-2

2,5-Dibromo-4-methylpyridine

3430-26-0

General procedure for the synthesis of 2,5-dibromo-4-methylpyridine from 2-amino-5-bromo-4-methylpyridine: 2-amino-5-bromo-4-methylpyridine (2.0 g, 10.7 mmol) was dissolved in 48% aqueous hydrobromic acid (14 mL, 123 mmol) and cooled to 2 °C in a salt/ice bath. Bromine (1.65 mL, 32.1 mmol) was added dropwise while keeping the internal temperature below 2 °C. Subsequently, a solution of sodium nitrite (3.69 g, 53.5 mmol) in water (5 mL) was added, keeping the internal temperature below 5 °C and the reaction mixture was stirred between 0 °C and 5 °C for 1 hour. The pH of the reaction mixture was adjusted to about 13 by slowly adding and cooling a 50% aqueous sodium hydroxide solution. after warming the reaction mixture to room temperature, it was extracted with ether. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated to give a brown oil. Purification by fast column chromatography on silica gel, using 5% ether/hexane as eluent, afforded the target product 2,5-dibromo-4-methylpyridine as a white solid (1.83 g, 7.29 mmol, 68% yield). Mass spectrometry analysis showed the [M + H]+ peak to be 251.9; the retention time (tR) was 2.3 min (Method 1).

References

[1] Patent: WO2008/124610, 2008, A1. Location in patent: Page/Page column 46
[2] Patent: WO2008/124614, 2008, A1. Location in patent: Page/Page column 38-39

2,5-Dibromo-4-methylpyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-bromo-4-methylpyridine Sodium nitrite Hydrogen bromide Sodium hydroxide

Preparation Products

5-Bromo-2-iodo-4-picoline

2,5-Dibromo-4-methylpyridine Suppliers

Global( 388)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai EachChem Co., Ltd. 021-64196659 13564486206 info@eachchem.com China 50 55
Fuxin Fengcheng Chemical Technology Development Co., Ltd. 0418-2868000 13464847801 jingxuan.lu@fcmeditech.com China 343 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Supplier Advantage
Shanghai EachChem Co., Ltd. 55
Fuxin Fengcheng Chemical Technology Development Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Liaoning Tianhua Chemical Co., Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65

View Lastest Price from 2,5-Dibromo-4-methylpyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,5-Dibromo-4-methylpyridine pictures 2026-09-11 2,5-Dibromo-4-methylpyridine
3430-26-0
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
2,5-Dibromo-4-methylpyridine pictures 2026-09-02 2,5-Dibromo-4-methylpyridine
3430-26-0
 $1.00-200.00 1KG 99%, 99.5% Sublimated Henan Fengda Chemical Co., Ltd
2,5-Dibromo-4-methylpyridine pictures 2026-08-20 2,5-Dibromo-4-methylpyridine
3430-26-0
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited

2,5-Dibromo-4-methylpyridine Spectrum

2,5-Dibromo-4-methylpyridine(3430-26-0)1HNMR2,5-Dibromo-4-methylpyridine(3430-26-0)FT-IR

3430-26-0(2,5-Dibromo-4-methylpyridine)Related Search:

2,5-Dibromo-3-nitropyridine 2,5-Dibromo-3-methylpyridine 2,5-Dibromo-6-methylpyridine 3,5-DIBROMO-4-METHYLPYRIDINE 2-Amino-3,5-dibromo-4-methylpyridine
2-fluoro-3，5-dibromo-4-methylpyridine 2-Chloro-3,5-dibromo-4-methylpyridine 3,5-Dibromo-2-methylpyridine 2,6-Dibromopyridine-4-carboxylic acid 2,5-Dibromo-4-methylpyridine
2-Amino-3,5-dibromo-6-methylpyridine 4-Amino-3,5-dibromo-2-methylpyridine 2,3-Dibromo-6-picoline 2,3-Dibromo-5-methylpyridine 2,5-Dibromopyridine-4-carboxaldehyde
2,5-Dibromo-4-(trifluoromethyl)pyridine 2,5-Dibromo-4-methyl-3-nitropyridine 2,4-Dibromo-3-methylpyridine

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TIMTEC-BB SBB003142 2,5-DIBROMO-4-METHYLPYRIDINE 2,5-DIBROMO-4-PICOLINE 2,5-Dibromo-4-picoline,98% 2,5-Dibromo-4-methylpyridine > 2,5-Dibromo-4-methyL Pyridine, 2,5-dibromo-4-methyl- 3-Chloro-3-iodopyridine 2,5-Dibromo-4-methylpyridine ISO 9001：2015 REACH 2,5-Dibromo-4-methylpyridine, 97% 2,5-Dibromo-4-methylpyridine, CAS 3430-26-0 2,3-dibromo-4-methylpyridine 3430-26-0 3430-26-2 C6H5NBr2 Brominated heterocyclic series Boronic Acid Pyridine Series Halides blocks Bromides Pyridines Pyridine bc0001