2,5-Dibromo-4-methylpyridine
- CAS No.
- 3430-26-0
- Chemical Name:
- 2,5-Dibromo-4-methylpyridine
- Synonyms
- TIMTEC-BB SBB003142;2,5-Dibromo-4-methyL;2,5-DIBROMO-4-PICOLINE;3-Chloro-3-iodopyridine;2,5-Dibromo-4-picoline,98%;2,3-dibromo-4-methylpyridine;2,5-DIBROMO-4-METHYLPYRIDINE;Pyridine, 2,5-dibromo-4-methyl-;2,5-Dibromo-4-methylpyridine >2,5-Dibromo-4-methylpyridine, 97%
- CBNumber:
- CB6140119
- Molecular Formula:
- C6H5Br2N
- Molecular Weight:
- 250.92
- MDL Number:
- MFCD00234955
- MOL File:
- 3430-26-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,5-Dibromo-4-methylpyridine 97% | 708143 | 1g | $64.7 |
| 2,5-Dibromo-4-methylpyridine >98.0%(GC) | D4058 | 1g | $27 |
| 2,5-Dibromo-4-methylpyridine >98.0%(GC) | D4058 | 5g | $69 |
| 2,5-Dibromo-4-methylpyridine | D425918 | 500mg | $65 |
| 2,5-Dibromo-4-methylpyridine | D425918 | 100mg | $45 |
| More product size | |||
| Melting point | 37-42 °C |
|---|---|
| Boiling point | 181.5°C (rough estimate) |
| Density | 1.9318 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| Flash point | 113° |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Methanol |
| pka | -0.91±0.18(Predicted) |
| form | Low Melting Solid |
| color | Light yellow to orange |
| InChI | InChI=1S/C6H5Br2N/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3 |
| InChIKey | WWJLJUAHQHXDGM-UHFFFAOYSA-N |
| SMILES | C1(Br)=NC=C(Br)C(C)=C1 |
| CAS DataBase Reference | 3430-26-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-20/21/22-41-37/38-22 | |||||||||
| Safety Statements | 36/37/39-26-39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2,5-Dibromo-4-methylpyridine price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 708143 | 2,5-Dibromo-4-methylpyridine 97% | 3430-26-0 | 1g | $64.7 | 2023-06-20 | Buy |
| TCI Chemical | D4058 | 2,5-Dibromo-4-methylpyridine >98.0%(GC) | 3430-26-0 | 1g | $27 | 2025-07-31 | Buy |
| TCI Chemical | D4058 | 2,5-Dibromo-4-methylpyridine >98.0%(GC) | 3430-26-0 | 5g | $69 | 2025-07-31 | Buy |
| TRC | D425918 | 2,5-Dibromo-4-methylpyridine | 3430-26-0 | 500mg | $65 | 2021-12-16 | Buy |
| TRC | D425918 | 2,5-Dibromo-4-methylpyridine | 3430-26-0 | 100mg | $45 | 2021-12-16 | Buy |
2,5-Dibromo-4-methylpyridine Chemical Properties,Uses,Production
Uses
2,5-Dibromo-4-methylpyridine is mainly used in organic synthesis, and in the pharmaceutical industry, it is used to synthesize heart disease drugs such as disopyramide (disopyramide phosphate). Disopyramide is used to maintain sinus rhythm in atrial fibrillation and atrial flutter, or to prevent the recurrence of ventricular tachycardia and ventricular fibrillation. It can also be used for premature atrial contractions, paroxysmal atrial tachycardia, premature ventricular contractions, etc.
Chemical Properties
Light yellow to orange low melting solid
Synthesis
98198-48-2
3430-26-0
General procedure for the synthesis of 2,5-dibromo-4-methylpyridine from 2-amino-5-bromo-4-methylpyridine: 2-amino-5-bromo-4-methylpyridine (2.0 g, 10.7 mmol) was dissolved in 48% aqueous hydrobromic acid (14 mL, 123 mmol) and cooled to 2 °C in a salt/ice bath. Bromine (1.65 mL, 32.1 mmol) was added dropwise while keeping the internal temperature below 2 °C. Subsequently, a solution of sodium nitrite (3.69 g, 53.5 mmol) in water (5 mL) was added, keeping the internal temperature below 5 °C and the reaction mixture was stirred between 0 °C and 5 °C for 1 hour. The pH of the reaction mixture was adjusted to about 13 by slowly adding and cooling a 50% aqueous sodium hydroxide solution. after warming the reaction mixture to room temperature, it was extracted with ether. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated to give a brown oil. Purification by fast column chromatography on silica gel, using 5% ether/hexane as eluent, afforded the target product 2,5-dibromo-4-methylpyridine as a white solid (1.83 g, 7.29 mmol, 68% yield). Mass spectrometry analysis showed the [M + H]+ peak to be 251.9; the retention time (tR) was 2.3 min (Method 1).
References
[1] Patent: WO2008/124610, 2008, A1. Location in patent: Page/Page column 46
[2] Patent: WO2008/124614, 2008, A1. Location in patent: Page/Page column 38-39
2,5-Dibromo-4-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20126 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13822 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21595 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29830 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
View Lastest Price from 2,5-Dibromo-4-methylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-11 | 2,5-Dibromo-4-methylpyridine
3430-26-0
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-12-01 | 2,5-Dibromo-4-methylpyridine
3430-26-0
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-11-18 | 2,5-Dibromo-4-methylpyridine
3430-26-0
|
US $1.10 / g | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited |
-
- 2,5-Dibromo-4-methylpyridine
3430-26-0
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2,5-Dibromo-4-methylpyridine
3430-26-0
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2,5-Dibromo-4-methylpyridine
3430-26-0
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
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