2,5-Dibromo-3-methylpyridine
- CAS No.
- 3430-18-0
- Chemical Name:
- 2,5-Dibromo-3-methylpyridine
- Synonyms
- TIMTEC-BB SBB003143;2,5-Dibromo-3-methyl;2,5-DIBROMO-3-PICOLINE;2,5-Dibromo-3-picoline,98%;2,5-DIBROMO-3-METHYLPYRIDINE;2-CHLORO-5-HYDROXY-3-PICOLINE;2,5-Di BroMo-3-Methyl Pyridnie;2,5-Dibromo-3-methylpyridine>Pyridine, 2,5-dibromo-3-methyl-;2,5-DibroMo-3-Methylpyridine, 97%, 97%
- CBNumber:
- CB0172392
- Molecular Formula:
- C6H5Br2N
- Molecular Weight:
- 250.92
- MDL Number:
- MFCD02093085
- MOL File:
- 3430-18-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 43-47 °C (lit.) |
|---|---|
| Boiling point | 114 °C / 6mmHg |
| Density | 1.9318 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| Flash point | >230 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| pka | -1.27±0.20(Predicted) |
| form | Crystalline Powder |
| color | Off-white to beige |
| InChI | InChI=1S/C6H5Br2N/c1-4-2-5(7)3-9-6(4)8/h2-3H,1H3 |
| InChIKey | LIMXEVCFAUTBCK-UHFFFAOYSA-N |
| SMILES | C1(Br)=NC=C(Br)C=C1C |
| CAS DataBase Reference | 3430-18-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H318 | |||||||||
| Precautionary statements | P280-P301+P310+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/38-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 |
|||||||||
| NFPA 704 |
|
2,5-Dibromo-3-methylpyridine price More Price(77)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 637661 | 2,5-Dibromo-3-methylpyridine 98% | 3430-18-0 | 1g | $28 | 2023-06-20 | Buy |
| Sigma-Aldrich | 637661 | 2,5-Dibromo-3-methylpyridine 98% | 3430-18-0 | 5g | $82.8 | 2023-01-07 | Buy |
| TCI Chemical | D3455 | 2,5-Dibromo-3-methylpyridine >98.0%(GC) | 3430-18-0 | 5g | $17 | 2026-04-30 | Buy |
| TCI Chemical | D3455 | 2,5-Dibromo-3-methylpyridine >98.0%(GC) | 3430-18-0 | 25g | $51 | 2026-04-30 | Buy |
| Usbiological | 273611 | 2,5-Dibromo-3-methylpyridiNe Asreported | 3430-18-0 | 25g | $442 | 2026-06-03 | Buy |
2,5-Dibromo-3-methylpyridine Chemical Properties,Uses,Production
Uses
2,5-Dibromo-3-methylpyridine is a pyridine organic compound, mainly used as a pharmaceutical intermediate.
Chemical Properties
Off-white to beige crystalline powder
Synthesis
3430-21-5
3430-18-0
General procedure for the synthesis of 2,5-dibromo-3-methylpyridine (49) from 2-amino-3-methyl-5-bromopyridine (48, 69 g, 0.37 mol): the raw material was suspended in hydrobromic acid (200 mL, 48% aqueous solution) and cooled to -15 °C. The reaction was carried out in aqueous solution of sodium nitrite (100 mL). Bromine (95 g, 0.59 mol) was slowly added dropwise, followed by an aqueous solution (100 mL) of sodium nitrite (69 g, 1 mol), while keeping the temperature of the reaction mixture below -15 °C. The reaction mixture was then cooled to -15 °C. After completion of the dropwise addition, the cooling bath was removed and the reaction mixture was stirred for 3 hours at room temperature. The reaction was cooled again to -15 °C and quenched with an aqueous solution (500 mL) of potassium hydroxide (112 g, 2 mol). After removing the cooling bath, stirring was continued for 1.5 hours. The product was extracted with ethyl acetate (3 x 300 mL), the organic phases were combined, washed sequentially with water (2 x 200 mL), saturated aqueous sodium bicarbonate (200 mL), dried over sodium sulfate and concentrated to dryness under reduced pressure. The oily residue was dissolved in chloroform (100 mL), filtered through a silica gel pad and washed with chloroform. The filtrates were combined and evaporated under reduced pressure to give the light yellow solid product 49 (87 g, 94%) with a melting point of 38-40 °C (literature value: 41-42 °C). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3) δ 8.22 (d, J = 2.4 Hz, 1H), 7.61 (d, J = 2.4 Hz, 1H), 2.33 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 148.29, 143.05, 141.15, 137.15, 119.68, 22.06 Confirmed.
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1682 - 1697
[2] Patent: US2014/18360, 2014, A1. Location in patent: Paragraph 0175
[3] Patent: CN105348177, 2016, A. Location in patent: Paragraph 0012; 0017
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 11, p. 1129 - 1131
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3730 - 3742
2,5-Dibromo-3-methylpyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| Aobolihui | 0917-18691729 18691729963 | 2553382659@qq.com | China | 4726 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Lastest Price from 2,5-Dibromo-3-methylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2,5-Dibromo-3-methylpyridine
3430-18-0
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 2,5-Dibromo-3-methylpyridine
3430-18-0
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-06-30 | 2,5-Dibromo-3-methylpyridine
3430-18-0
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2,5-Dibromo-3-methylpyridine
3430-18-0
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2,5-Dibromo-3-methylpyridine
3430-18-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2,5-Dibromo-3-methylpyridine
3430-18-0
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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