2,3-Dibromo-5-methylpyridine
- CAS No.
- 29232-39-1
- Chemical Name:
- 2,3-Dibromo-5-methylpyridine
- Synonyms
- 2,3-DIBROMO-5-METHYL;5,6-Dibromo-3-picoline;5,6-Dibromo-m-picoline;2,3-DIBROMO-5-PICOLINE;2,3-Dibromo-5-methylpyridine;Pyridine,2,3-dibroMo-5-Methyl-;2,3-DIBROMO-5-METHYLPYRIDINE 98%;3-Bromo-6-hydroxy-3-methylpyridine;5,6-dibromo-3-methyl-3,4-dihydropyridine;2,3-DIBROMO-5-METHYLPYRIDINE ISO 9001：2015 REACH
- CBNumber:
- CB9415294
- Molecular Formula:
- C6H5Br2N
- Molecular Weight:
- 250.92
- MDL Number:
- MFCD04112574
- MOL File:
- 29232-39-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 53.0 to 57.0 °C |
|---|---|
| Boiling point | 270.8±35.0 °C(Predicted) |
| Density | 1.911±0.06 g/cm3(Predicted) |
| Flash point | >110℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| pka | -1.27±0.20(Predicted) |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| InChI | 1S/C6H5Br2N/c1-4-2-5(7)6(8)9-3-4/h2-3H,1H3 |
| InChIKey | BZUZAZMAGVFIBS-UHFFFAOYSA-N |
| SMILES | Cc1cnc(Br)c(Br)c1 |
| CAS DataBase Reference | 29232-39-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H318 | |||||||||
| Precautionary statements | P280-P301+P310+P330-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 20/21/22-36/37/38-41-25 | |||||||||
| Safety Statements | 26-36/37/39-45-39 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 |
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| NFPA 704 |
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2,3-Dibromo-5-methylpyridine price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 715727 | 2,3-Dibromo-5-methylpyridine 97% | 29232-39-1 | 1g | $50.5 | 2023-01-07 | Buy |
| TCI Chemical | D5100 | 2,3-Dibromo-5-methylpyridine >98.0%(GC) | 29232-39-1 | 5g | $45 | 2026-04-30 | Buy |
| TCI Chemical | D5100 | 2,3-Dibromo-5-methylpyridine >98.0%(GC) | 29232-39-1 | 25g | $228 | 2021-12-16 | Buy |
| Usbiological | 273466 | 2,3-Dibromo-5-methylpyridine Asreported | 29232-39-1 | 1g | $319 | 2026-06-03 | Buy |
| Usbiological | 273466 | 2,3-Dibromo-5-methylpyridine Asreported | 29232-39-1 | 2g | $429 | 2026-06-03 | Buy |
2,3-Dibromo-5-methylpyridine Chemical Properties, Uses, Production
Uses
2,3-Dibromo-5-methylpyridine serves as a substrate for the synthesis of heterocyclic phenothiazines and regioselective cross-coupling products[2][3]. It functions as an additive in iododesilylation reactions, where it provides a slight yield improvement compared to other pyridine-based additives[1].
Synthesis
17282-00-7
29232-39-1
2-Amino-3-bromo-5-methylpyridine (187 mg, 1.00 mmol) was added to a 30 mL three-necked flask, followed by the addition of 48% aqueous hydrogen bromide (1 mL) to dissolve the feedstock. The reaction mixture was cooled in an ice bath, keeping the internal temperature in the range of 2 to 5 °C, and bromine (154 μL, 3.00 mmol) was slowly added dropwise. After the dropwise addition, stirring was continued at the same temperature for 10 min. Subsequently, a solution of sodium nitrite (174 mg, 2.5 mmol) dissolved in water (500 μL) was added dropwise to the reaction system while keeping the temperature unchanged, and stirring was continued for 1 h after completion of the dropwise addition. After completion of the reaction, a solution of sodium hydroxide (377 mg, 9.4 mmol) dissolved in water (2 mL) was added slowly and the mixture was stirred for 1 h at room temperature. The reaction solution was transferred to a partition funnel and separated by extraction with ethyl acetate (10 mL) and water (10 mL), and the aqueous phase was extracted once more with ethyl acetate (10 mL). The organic phases were combined and washed sequentially with 5% aqueous sodium sulfite (5 mL) and saturated saline (10 mL), then dried with anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to afford the target product 2,3-dibromo-5-methylpyridine (244 mg, 0.97 mmol) as a yellow solid in 97% yield. The product was analyzed by 1H-NMR (CDCl3, TMS, 300 MHz) δ (ppm): 2.30 (s, 3H), 7.73 (d, 1H, J = 1.5 Hz), 8.14 (d, 1H, J = 1.2 Hz); 13C-NMR (CDCl3, TMS, 300 MHz) δ (ppm): 17.41, 123.16. 134.13, 140.39, 142.29, 148.57; high-resolution mass spectrometry (C6H5Br2N) Theoretical: [M+] 248.8789, Measured: [M+] 248.8786; Melting point 54.2 °C.
References
[1]Bloux, H., Dahiya, A., Hébert, A., Fabis, F., Schoenebeck, F., & Cailly, T. (2023). Base‐Mediated Radio‐Iodination of Arenes by Using Organosilane and Organogermane as Radiolabelling Precursors. Chemistry – A European Journal, 29(19). https://doi.org/10.1002/chem.202203366
[2]Hu, W., & Zhang, S. (2015). Method for the Synthesis of Phenothiazines via a Domino Iron-Catalyzed C–S/C–N Cross-Coupling Reaction. The Journal of Organic Chemistry, 80(12), 6128–6132. https://doi.org/10.1021/acs.joc.5b00568
[3]Hikawa, H., & Yokoyama, Y. (2010). Cross-coupling reaction on N-(3,5-dibromo-2-pyridyl)piperazines: regioselective synthesis of 3,5-disubstituted pyridylpiperazines. <i>Tetrahedron</i>, <i>66 49</i>, Pages 9552-9559. https://doi.org/10.1016/j.tet.2010.09.100
2,3-Dibromo-5-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Latest Price from 2,3-Dibromo-5-methylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2,3-Dibromo-5-picoline
29232-39-1
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 2,3-DIBROMO-5-METHYLPYRIDINE
29232-39-1
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-30 | 2,3-DIBROMO-5-METHYLPYRIDINE
29232-39-1
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2,3-Dibromo-5-picoline
29232-39-1
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 2,3-DIBROMO-5-METHYLPYRIDINE
29232-39-1
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2,3-DIBROMO-5-METHYLPYRIDINE
29232-39-1
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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