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PDE11A4-IN-1

PDE11A4-IN-1 structure

CAS No.: 3027607-92-4

Chemical Name:: PDE11A4-IN-1

Synonyms: PDE11A4-IN-1;1H-Pyrazolo[3,4-b]pyridine-4-carboxamide, 3-(difluoromethyl)-N,N-diethyl-6-(1-methyl-1H-pyrazol-5-yl)-1-phenyl-

CBNumber:: CB614284513

Molecular Formula:: C22H22F2N6O

Molecular Weight:: 424.45

MDL Number:

MOL File:: 3027607-92-4.mol

Last updated:2025-04-18 09:51:18

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PDE11A4-IN-1 Properties

Boiling point	589.2±50.0 °C(predicted)
Density	1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	0.92±0.10(predicted)

PDE11A4-IN-1 Chemical Properties,Uses,Production

Uses

PDE11A4-IN-1 (compound 23b) is a potent and selective PDE11A4 inhibitor with an IC50 of 12 nM. PDE11A4-IN-1 show high selectivity for PDE11A4 over PDE1, PDE2, PDE7, PDE8, and PDE9[1].

IC 50

PDE11A4: 12 nM (IC₅₀)

References

[1] Shams Ul Mahmood, et al. First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline. J Med Chem. 2023 Oct 20. DOI:10.1021/acs.jmedchem.3c01088

PDE11A4-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

PDE11A4-IN-1 Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Invivochem	--	191781430@QQ.com	China	21	58

Supplier	Advantage
Invivochem	58

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PDE11A4-IN-1 1H-Pyrazolo[3,4-b]pyridine-4-carboxamide, 3-(difluoromethyl)-N,N-diethyl-6-(1-methyl-1H-pyrazol-5-yl)-1-phenyl- 3027607-92-4