2-Bromohexadecanoic acid
- CAS No.
- 18263-25-7
- Chemical Name:
- 2-Bromohexadecanoic acid
- Synonyms
- 2-bromopalmitate;2-BROMOPALMITIC ACID;Hexadecanoic acid, 2-bromo-;A-BROMOPALMITIC ACID;ALPHA-BROMOPALMITATE;α-Bromopalmitic acid;Bromohexadecanoicacid;2-bromo-hexadecanoicaci;2-Bromohexadecanoic acid;2-Bromohexadecanoicacid97%
- CBNumber:
- CB6143327
- Molecular Formula:
- C16H31BrO2
- Molecular Weight:
- 335.32
- MDL Number:
- MFCD00004215
- MOL File:
- 18263-25-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 52-54 °C |
|---|---|
| Boiling point | 403.4±18.0 °C(Predicted) |
| Density | 1.1985 (rough estimate) |
| refractive index | 1.4650 (estimate) |
| Flash point | 113 °C |
| storage temp. | RT |
| solubility | methanol: soluble1g/10 mL, clear, colorless |
| pka | 2.97±0.21(Predicted) |
| form | solid |
| color | White |
| BRN | 1726517 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| InChI | InChI=1S/C16H31BrO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(17)16(18)19/h15H,2-14H2,1H3,(H,18,19) |
| InChIKey | DPRAYRYQQAXQPE-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C(Br)CCCCCCCCCCCCCC |
| CAS DataBase Reference | 18263-25-7(CAS DataBase Reference) |
| FDA UNII | 7EI4G5X28Z |
| EPA Substance Registry System | Hexadecanoic acid, 2-bromo- (18263-25-7) |
| UNSPSC Code | 12352203 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2915907098 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2-Bromohexadecanoic acid price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 238422 | 2-Bromohexadecanoic acid ~97% | 18263-25-7 | 10g | $56.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 21604 | 2-Bromohexadecanoic acid ≥99.0% (GC) | 18263-25-7 | 1g | $112 | 2026-04-30 | Buy |
| TRC | TRC-B182637-5G | 2-Bromopalmitic Acid | 18263-25-7 | 5g | $109 | 2026-06-03 | Buy |
| TRC | TRC-B182637-1G | 2-Bromopalmitic Acid | 18263-25-7 | 1g | $76 | 2026-06-03 | Buy |
| TRC | TRC-B182637-10G | 2-Bromopalmitic Acid | 18263-25-7 | 10g | $173 | 2026-06-03 | Buy |
2-Bromohexadecanoic acid Chemical Properties,Uses,Production
Description
2-Bromopalmitic acid (18263-25-7) inhibitsprotein S-palmitoylation.1 Blocks palmitic acid-induced increase in cAMP levels in human primary melanocytes expressing the melanocortin-1 receptor which undergoes an essential palmitoylation as a prerequisite for receptor signaling.2
Chemical Properties
WHITE CRYSTALLINE POWDER
Uses
2-Bromopalmitic Acid is used in preparation of substituted purines and their analogs for inhibiting the expression of a pattern recognition receptor.
Definition
ChEBI: A bromo fatty acid that is hexadecanoic (palmitic) acid carrying a single bromo substituent at position 2.
General Description
PPARδ (peroxisome proliferator-activated receptor, delta isoform) acts as a transcription factor for gene expression as well as playing a role in lipid metabolism regulation; activity of this receptor is ligand-regulated. 2-Bromohexadecanoic acid is a metabolically stable analoge of the fatty acid palmitic acid that has been shown to be a natural ligand for the PPARδ receptor. 2-Bromohexadecanoic acid has also been used in studies of fatty acid oxidation, palmitoylation, and glucose uptake.
Biochem/physiol Actions
2-Bromohexadecanoic acid is a PPARδ agonist. It has also been shown to inhibit fatty acid oxidation, inhibit DHHC-mediated palmitoylation, and promote glucose uptake in rat cardiac cells and the insulin-sensitive murine fibroblast line A31-IS.
Purification Methods
Recrystallise the acid from pet ether (b 60-80o, charcoal) and finally from EtOH. The ethyl ester has b 177-178o/2mm, d28 1.0484, n D 1.4560. [IR: Sweet & Estes J Org Chem 21 1426 1956, Beilstein 2 IV 1184.]
References
[1] TAKASHI TSUKAMOTO. Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells.[J]. PLoS ONE, 2013: e75831. DOI:10.1371/journal.pone.0075831
[2] SHUYANG CHEN. Palmitoylation-dependent activation of MC1R prevents melanomagenesis[J]. Nature, 2017, 549 7672: 399-403. DOI:10.1038/nature23887
2-Bromohexadecanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Shanghai Hao Yun Chemical Science Co.,Ltd. | 021-68367562 | sales@haoyunchem.com | China | 493 | 55 |
| Ningbo Taikang Chemical Co., Ltd. | 0574-87365517 18074210286 | sales@taikangchem.com | China | 294 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
View Lastest Price from 2-Bromohexadecanoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | 2-Bromohexadecanoic acid
18263-25-7
|
$37.00-90.00 | 99.90% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-02-13 | 2-bromohexadecanoic acid
18263-25-7
|
$1.00 | 1g | 0.98 | 1000 | Apeloa production Co.,Limited |
-
- 2-Bromohexadecanoic acid
18263-25-7
- $37.00-90.00
- 99.90%
- TargetMol Chemicals Inc.
-
- 2-bromohexadecanoic acid
18263-25-7
- $1.00
- 0.98
- Apeloa production Co.,Limited
