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5-Bromo-3-methoxypyrazin-2-ylamine

5-Bromo-3-methoxypyrazin-2-ylamine structure

CAS No.: 5900-13-0

Chemical Name:: 5-Bromo-3-methoxypyrazin-2-ylamine

Synonyms: 5-BROMO-3-METHOXYPYR;5-BroMo-3-MethoxypyrazinaMine;2-Amino-5-Bromo-3-methoxypyra;2-Amino-5-Bromo-3-methoxypyrazin;5-Bromo-3-methoxy-2-pyrazinamine;3-Methoxy-5-bromopyrazin-2-amine;5-bromo-3-methoxypyrazin-2-amine;2-AMINO-5-BROMO-3-METHOXYPYRAZINE;2-Amino-3-methoxy-5-bromopyrazine;2-PyrazinaMine, 5-broMo-3-Methoxy-

CBNumber:: CB6145518

Molecular Formula:: C5H6BrN3O

Molecular Weight:: 204.02

MDL Number:: MFCD08275726

MOL File:: 5900-13-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:53:50

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5-Bromo-3-methoxypyrazin-2-ylamine Properties

Melting point	135-140 °C
Boiling point	262 ºC
Density	1.723
refractive index	1.
Flash point	112 ºC
storage temp.	2-8°C
solubility	DMSO, Methanol
form	Solid
pka	1.93±0.10(Predicted)
color	Off-White
InChI	1S/C5H6BrN3O/c1-10-5-4(7)8-2-3(6)9-5/h2H,1H3,(H2,7,8)
InChIKey	QDFJJHGAODFQMN-UHFFFAOYSA-N
SMILES	COc1nc(Br)cnc1N
CAS DataBase Reference	5900-13-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS07
Signal word	Danger
Hazard statements	H302-H315-H318-H335
Precautionary statements	P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
target organs	Respiratory system
Hazard Codes	Xn
Risk Statements	22-37/38-41
Safety Statements	26-39
WGK Germany	3
HS Code	2933998090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3

5-Bromo-3-methoxypyrazin-2-ylamine price More Price(70)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	732125	2-Amino-5-bromo-3-methoxypyrazine 95%	5900-13-0	500mg	$73.2	2023-01-07	Buy
TCI Chemical	A2562	2-Amino-5-bromo-3-methoxypyrazine >99.0%(GC)(T)	5900-13-0	1g	$37	2026-04-30	Buy
Usbiological	266264	5-Bromo-3-methoxypyrazin-2-amine Asreported	5900-13-0	500mg	$375	2026-06-03	Buy
Usbiological	266264	5-Bromo-3-methoxypyrazin-2-amine Asreported	5900-13-0	1g	$575	2026-06-03	Buy
Usbiological	266264	5-Bromo-3-methoxypyrazin-2-amine Asreported	5900-13-0	2g	$801	2026-06-03	Buy

Product number	Packaging	Price	Buy
732125	500mg	$73.2	Buy
A2562	1g	$37	Buy
266264	500mg	$375	Buy
266264	1g	$575	Buy
266264	2g	$801	Buy

5-Bromo-3-methoxypyrazin-2-ylamine Chemical Properties, Uses, Production

Chemical Properties

Off-White Solid

Uses

5-Bromo-3-methoxy-2-pyrazinamine is an intermediate in the preparation of N-pyrazinylbenzenesulfonamides used in treatment of chemokine mediated diseases such as asthma.

Synthesis

124-41-4

24241-18-7

5900-13-0

1. A 30% w/w methanolic solution of sodium methanolate (8.4 mL, 44.8 mmol) was slowly added to a stirring suspension of 3,5-dibromo-2-aminopyrazine (10 g, 39.5 mmol) in anhydrous methanol (40 mL). 2. The reaction mixture was heated to reflux and the reaction was maintained for 3 h. 3. Upon completion of the reaction, the reaction was cooled to room temperature and concentrated to 1/3 of the original volume by rotary evaporation. 4. The concentrated reaction mixture was partitioned between dichloromethane (DCM) and saturated aqueous sodium bicarbonate (NaHCO3).5 The organic and aqueous layers were separated and the organic phase was washed three times with saturated aqueous NaHCO3.6 The aqueous phases were combined and back-extracted three times with DCM.7 All the organic phases were combined, washed with saturated saline, dried with anhydrous sodium sulfate, filtered, and concentrated to give 5 mL of the reaction mixture.8 The reaction mixture was then dried. dried, filtered and concentrated to give 5-bromo-3-methoxypyrazin-2-amine (8.1 g). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.64 (s, 1H), 4.79 (br s, 2H), 4.01 (s, 3H).

References

[1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 9, p. 981 - 986
[2] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 5, p. 1149 - 1154
[3] Patent: US2013/210818, 2013, A1. Location in patent: Paragraph 0384
[4] Patent: WO2014/68171, 2014, A1. Location in patent: Page/Page column 27
[5] Patent: WO2009/115572, 2009, A2. Location in patent: Page/Page column 116

5-Bromo-3-methoxypyrazin-2-ylamine Preparation Products And Raw materials

Raw materials

Sodium Methoxide 2-Amino-3,5-dibromopyrazine

Preparation Products

5-Bromo-2-iodo-3-methoxypyrazine 2,5-Dibromo-3-methoxypyrazine 5-broMo-3-Methoxypyrazin-2-ol

5-Bromo-3-methoxypyrazin-2-ylamine Suppliers

Global Suppliers ( 203)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
ZEROSCHEM.CO.,LTD.	10-61256048 13810278579;	sales@zeroschem.com	China	1401	59
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16306	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Accela ChemBio Co.,Ltd.	64
ZEROSCHEM.CO.,LTD.	59
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
China DongFan Chemical Co.,LTD	66

View Latest Price from 5-Bromo-3-methoxypyrazin-2-ylamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	5-Bromo-3-methoxypyrazin-2-amine 5900-13-0	$2.20-8.80	1kg	99%min	1000kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-08-20	5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE 5900-13-0	$1.10	1g	99.00%	100 Tons	Dideu Industries Group Limited
2020-04-30	2-Amino-5-bromo-3-methoxypyrazine 5900-13-0		1KG	99.0%+	800 tons	Shaanxi Dideu Medichem Co. Ltd

5-Bromo-3-methoxypyrazin-2-amine
5900-13-0
$2.20-8.80
99%min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE
5900-13-0
$1.10
99.00%
Dideu Industries Group Limited

2-Amino-5-bromo-3-methoxypyrazine
5900-13-0
99.0%+
Shaanxi Dideu Medichem Co. Ltd

5-Bromo-3-methoxypyrazin-2-ylamine Spectrum

5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE(5900-13-0)¹HNMR

5900-13-0 (5-Bromo-3-methoxypyrazin-2-ylamine) Related Search:

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1of2

2-AMINO-5-BROMO-3-METHOXYPYRAZINE 5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE, 95+% 3-Methoxy-5-bromopyrazin-2-amine 5-Bromo-3-methoxy-2-pyrazinamine 2-Amino-5-Bromo-3-methoxypyrazin 5-BROMO-3-METHOXYPYR 5-bromo-3-methoxypyrazin-2-amine 2-aiMino-5-broMo-3-Methoxypyrazine 2-PyrazinaMine, 5-broMo-3-Methoxy- 5-BroMo-3-MethoxypyrazinaMine 5-Bromo-3-methoxypyrazin-2-amine, 2-Amino-5-bromo-3-methoxy-1,4-diazine 2-Amino-5-Bromo-3-methoxypyra 2-Amino-3-methoxy-5-bromopyrazine 2-Amino-5-bromo-3-methoxypyrazine > 5-amino-6-methoxypyrazine-2-carbonitrile 5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE ISO 9001：2015 REACH 5-Bromo-3-methoxypyrazin-2-ylamine 5900-13-0 amine|alkyl bromide