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2-Amino-3,5-dibromopyrazine

2-Amino-3,5-dibromopyrazine Structure
2-Amino-3,5-dibromopyrazine structure
CAS No.
24241-18-7
Chemical Name:
2-Amino-3,5-dibromopyrazine
Synonyms
3,5-DIBROMOPYRAZIN-2-AMINE;Amino-3,5-dibromopyrazine;2-AMINO-3,5-DIBROMOPYRAZIN;3,5-DIBROMOPYRAZIN-2-YLAMINE;2-Amino-3,5-dibromop;3,5-dibromo-2-aminop;Alprostadil Impurity 16;5-dibromo-2-aminopyrazine;3,5-dibromo-2-Pyrazinamine;2-AMINO-3,5-DIBROMOPYRAZINE
CBNumber:
CB5245202
Molecular Formula:
C4H3Br2N3
Molecular Weight:
252.89
MDL Number:
MFCD00673150
MOL File:
24241-18-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:19:51
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2-Amino-3,5-dibromopyrazine Properties

Melting point 114-117 °C (lit.)
Boiling point 294.6±35.0 °C(Predicted)
Density 2.287±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility soluble in Methanol
pka 0.81±0.10(Predicted)
form Powder
color Yellow to brown
InChI InChI=1S/C4H3Br2N3/c5-2-1-8-4(7)3(6)9-2/h1H,(H2,7,8)
InChIKey DTLBKXRFWUERQN-UHFFFAOYSA-N
SMILES C1(N)=NC=C(Br)N=C1Br
CAS DataBase Reference 24241-18-7(CAS DataBase Reference)
UNSPSC Code 12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Skull and Crossbones (GHS06)Exclamation Mark (GHS07)
GHS05,GHS06,GHS07
Signal word  Danger
Hazard statements  H301-H315-H318-H335-H319
Precautionary statements  P280g-P261-P280-P301+P310-P305+P351+P338-P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-37/38-41
Safety Statements  26-36/39
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
HazardClass  6.1
PackingGroup  III
HS Code  29339900
Storage Class 6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
1
2 0

2-Amino-3,5-dibromopyrazine price More Price(89)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 494364 2-Amino-3,5-dibromopyrazine 97% 24241-18-7 1g $33.9 2023-06-20 Buy
TCI Chemical A1806 2-Amino-3,5-dibromopyrazine >98.0%(GC) 24241-18-7 1g $31 2026-04-30 Buy
TCI Chemical A1806 2-Amino-3,5-dibromopyrazine >98.0%(GC) 24241-18-7 5g $93 2026-04-30 Buy
TRC TRC-A604635-25G 2-Amino-3,5-dibromopyrazine 24241-18-7 25g $1520 2026-06-03 Buy
TRC TRC-A604635-2.5G 2-Amino-3,5-dibromopyrazine 24241-18-7 2.5g $195 2026-06-03 Buy
Product number Packaging Price Buy
494364 1g $33.9 Buy
A1806 1g $31 Buy
A1806 5g $93 Buy
TRC-A604635-25G 25g $1520 Buy
TRC-A604635-2.5G 2.5g $195 Buy

2-Amino-3,5-dibromopyrazine Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powde

Uses

2-Amino-3,5-dibromopyrazine is used in the preparation of conjugated polymers for neurotoxin detection. 2-Amino-3,5-dibromopyrazine is an intermediate in the preparation of rho kinase (ROCK) inhibitor s.

Uses

2-Amino-3,5-dibromopyrazine may be used in the synthesis of:

  • 2-amino-5-bromopyrazin-3-thiol
  • 2-amino-3,5-bis(p-methoxyphenyl)-1,4-pyrazine
  • 3,7-dihydroimidazo[1,2a]pyrazine-3-ones

General Description

2-Amino-3,5-dibromopyrazine can be synthesized from 2-aminopyrazine via bromination using N-bromosuccinimide (NBS). It reacts with sodium dicyanocuprate to form a mixture of mono and dicyanation products. The formation of 2-aminothiazolopyrazines by reacting 2-amino-3,5-dibromopyrazine with isothiocyanates has been reported.

Synthesis

Aminopyrazine

5049-61-6

2-Amino-3,5-dibromopyrazine

24241-18-7

The general procedure for the synthesis of 2-amino-3,5-dibromopyrazine from 2-aminopyrazine was as follows: 2-aminopyrazine (9.5 g, 100 mmol) was added to a reaction flask containing glacial acetic acid (70 mL) and heated on a steam bath until completely dissolved. Subsequently, sodium acetate trihydrate (33 g, 243 mmol) was added and constant stirring was maintained. The reaction mixture was cooled in an ice-salt bath at -5°C and bromine (16 mL) was added slowly and dropwise over a period of 4 hours (note: rapid addition of bromine may result in uncontrolled reaction and pose a safety hazard). After the dropwise addition was completed, stirring was continued in the ice bath for 2 hours, then moved to room temperature and stirred for 24 hours. Upon completion of the reaction, the mixture was poured into ice (50 g) and neutralized by adjusting to pH 8 with concentrated ammonia. The crude product was collected by filtration and recrystallized from methanol (with the addition of Norit activated charcoal) to give the final 2-amino-3,5-dibromopyrazine in colorless needles (16.8 g, 66% yield) with a melting point of 113-114 °C (literature value: 114-115 °C).

References

[1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 9, p. 981 - 986
[2] Journal of Organic Chemistry, 1983, vol. 48, # 7, p. 1064 - 1069
[3] RSC Advances, 2015, vol. 5, # 47, p. 37887 - 37895
[4] RSC Advances, 2018, vol. 8, # 18, p. 9707 - 9717
[5] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 5, p. 1149 - 1154

2-Amino-3,5-dibromopyrazine Preparation Products And Raw materials

Raw materials

Aminopyrazine Sodium acetate Acetic acid

Preparation Products

2-Amino-5-bromopyrazine Aminopyrazine 6,8-Dibromoimidazo[1,2-a]pyrazine 5-Bromo-pyrazine-2,3-diamine 2-Amino-5-bromo-3-ethoxypyrazine
5-BroMo-3-(4-fluoro-phenyl)-pyrazin-2-ylaMine 3-Amino-6-bromo-1H-pyrazine-2-thione

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2-Amino-3,5-dibromopyrazine Suppliers

Global Suppliers ( 537)
Supplier Tel Email Country ProdList Advantage
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD 0838-2809458 13350585791 pharm@biots.cn China 778 58
Hangzhou Chemtrue Bio-Tech Co.,Ltd. 19967494293 sales@chemtrue-bio.com China 303 58
Tongchuang Pharma(Suzhou). Co., Ltd. 0512-63263366 18912765016 tongtf110@sina.com China 984 62
Foshan Junzheng Biotechnology Co., Ltd 17813018085 181367029@qq.com China 62 58
Shandong Dinghao Biological Technology Co. LTD 0531-82616988 18300239268 xinhuang@sddhpharm.com China 92 58
Shanghai ZC Pharma Co.,Ltd 19356322063 biz@zcpharma.com China 11 58
Shan Dong FengJin Pharmaceutical Co.,Ltd. 18364437686 18364437686 15066764791@163.com China 33 58
Wuhan EnTai Technology Development Co,.Ltd 86-27-82330560 2536851935@qq.com China 346 69
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Supplier Advantage
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD 58
Hangzhou Chemtrue Bio-Tech Co.,Ltd. 58
Tongchuang Pharma(Suzhou). Co., Ltd. 62
Foshan Junzheng Biotechnology Co., Ltd 58
Shandong Dinghao Biological Technology Co. LTD 58
Shanghai ZC Pharma Co.,Ltd 58
Shan Dong FengJin Pharmaceutical Co.,Ltd. 58
Wuhan EnTai Technology Development Co,.Ltd 69
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62

View Latest Price from 2-Amino-3,5-dibromopyrazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-3,5-dibromopyrazine pictures 2026-09-18 2-Amino-3,5-dibromopyrazine
24241-18-7
 1KG ≥99% 100mt/year Jinan Finer Chemical Co., Ltd
2-Amino-3,5-dibromopyrazine pictures 2026-09-02 2-Amino-3,5-dibromopyrazine
24241-18-7
 $5.00 1KG 98% Henan Fengda Chemical Co., Ltd
2-Amino-3,5-dibromopyrazine pictures 2026-08-20 2-Amino-3,5-dibromopyrazine
24241-18-7
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited

2-Amino-3,5-dibromopyrazine Spectrum

2-Amino-3,5-dibromopyrazine(24241-18-7)1HNMR2-Amino-3,5-dibromopyrazine(24241-18-7)IR

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2-AMINO-3,5-DIBROMOPYRAZINE 3,5-DIBROMOPYRAZIN-2-YLAMINE 3,5-DIBROMOPYRAZINE-2-YLAMINE 3,5-dibromo-2-Pyrazinamine 3,5-dibromo-2-aminopyrazine 2-Amino-3,5-dibromopyrazine ,98% 2-Amino-3,5-dibromop 2-PyrazinaMine, 3,5-dibroMo- 3,5-Dibromopyrazin-2-amine, 2-Amino-3,5-dibromo-1,4-diazine Amino-3,5-dibromopyrazine 2-Amino-3,5-dibromopyrazine > 2-Amino-3,5-dibromopyrazine ISO 9001：2015 REACH best 2-Amino-3,5-dibromopyrazine CAS 24241-18-7 2-Amino-3,5-dibromopyrazine 2-Amino-3,5-dibromo-1,4-diazine 3-amino-2,6-dibromopyrazine 5-dibromo-2-aminopyrazine Alprostadil Impurity 16 2-Amino-3,5-dibromopyrazineazine 3,5-dibromo-2-aminop 3,5-DIBROMOPYRAZIN-2-AMINEChemicalbook 2-AMINO-3,5-DIBROMOPYRAZIN 3,5-DIBROMOPYRAZIN-2-AMINE 24241-18-7 24241-81-7 24241-19-7 C4H3Br2N3 Halogenated Heterocycles Heterocyclic Building Blocks Pyrazines Chloropyrazines, etc. Building Blocks Chloropyrazines, etc. Pyrazine Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrazinesHeterocyclic Building Blocks Pyrazines pharmacetical amine| alkyl bromide