2,4-dichloro-6-(trifluoromethyl)pyrimidine
- CAS No.
- 16097-64-6
- Chemical Name:
- 2,4-dichloro-6-(trifluoromethyl)pyrimidine
- Synonyms
- 4-Dichloro-6-(trifluoromethyl)pyrimidine;2,4-dichloro-6-(trifluoromethyl)pyrimidine;2,4-Dichloro-6-(trifluoromethyl)-1,3-diazine;PyriMidine, 2,4-dichloro-6-(trifluoroMethyl)-;2,4-Dichloro-6-(trifluoromethyl)pyrimidine 98%;2,4-dichloro-6-(trifluoromethyl)pyrimidine ISO 9001：2015 REACH
- CBNumber:
- CB61456459
- Molecular Formula:
- C5HCl2F3N2
- Molecular Weight:
- 216.98
- MDL Number:
- MFCD09910264
- MOL File:
- 16097-64-6.mol
- MSDS File:
- SDS
| Melting point | -48--46 °C |
|---|---|
| Boiling point | 37-38 °C(Press: 0.7 Torr) |
| Density | 1.589 |
| refractive index | 1.4640 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -7.56±0.32(Predicted) |
| form | Liquid |
| color | Pale yellow |
| InChI | InChI=1S/C5HCl2F3N2/c6-3-1-2(5(8,9)10)11-4(7)12-3/h1H |
| InChIKey | ZTNFYAJHLPMNSN-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(C(F)(F)F)=CC(Cl)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| HS Code | 29335990 |
2,4-dichloro-6-(trifluoromethyl)pyrimidine price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC10677 | 2,4-Dichloro-6-(trifluoromethyl)pyrimidine 98% | 16097-64-6 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC10677 | 2,4-Dichloro-6-(trifluoromethyl)pyrimidine 98% | 16097-64-6 | 5g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC10677 | 2,4-Dichloro-6-(trifluoromethyl)pyrimidine 98% | 16097-64-6 | 10g | $32 | 2026-06-04 | Buy |
| Apolloscientific | PC10677 | 2,4-Dichloro-6-(trifluoromethyl)pyrimidine 98% | 16097-64-6 | 25g | $74 | 2026-06-04 | Buy |
| Apolloscientific | PC10677 | 2,4-Dichloro-6-(trifluoromethyl)pyrimidine 98% | 16097-64-6 | 100g | $270 | 2026-06-04 | Buy |
2,4-dichloro-6-(trifluoromethyl)pyrimidine Chemical Properties,Uses,Production
Uses
2,4-Dichloro-6-trifluoromethylpyrimidine is a useful synthetic intermediate. It can be used to synthesize 2,4-diaminopyrimidines derivatives that show antiplasmodial activities.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 24, p. 1243, 1987 DOI: 10.1002/jhet.5570240502
Synthesis
672-45-7
16097-64-6
Synthesis of 2,4-dichloro-6-trifluoromethylpyrimidine (XXVII): 6-(trifluoromethyl)uracil (XXVI) (10.0 g, 55 mmol) was dissolved in anhydrous acetonitrile (50 mL) under dry conditions. Subsequently, N,N-dimethylaniline (6.5 mL, 51 mmol) and phosphorus oxychloride (POCl3) (19 mL, 204 mmol) were added sequentially to the reaction system. Almost complete dissolution of the solids was observed, forming a dark colored solution. The reaction mixture was heated to reflux and the reflux reaction was maintained for 6 hours. Upon completion of the reaction, the heating was stopped and the volatile components were removed under reduced pressure. The residue was dissolved in ether (Et2O) (300 mL), the resulting ether solution was washed sequentially with deionized water (2 x 200 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated to give 2,4-dichloro-6-trifluoromethylpyrimidine (XXVII) as a yellow oil (11.3 g, 94% yield). The product was characterized by 1H NMR (CDCl3): δ 7.7 (s, 1H); GC/MS analysis showed m/z (relative abundance) 220 (12), 218 (67), 216 (100).
References
[1] Patent: US2009/93480, 2009, A1. Location in patent: Page/Page column 6-7
[2] Patent: WO2016/42452, 2016, A1. Location in patent: Page/Page column 114; 115
[3] Patent: WO2016/42453, 2016, A1. Location in patent: Page/Page column 51
[4] European Journal of Organic Chemistry, 2006, # 6, p. 1593 - 1598
[5] Patent: WO2015/191630, 2015, A1. Location in patent: Paragraph 00398
2,4-dichloro-6-(trifluoromethyl)pyrimidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Weiyuan Technology Co., Ltd. | 13024122785 17356341931 | sales@shweiyuan.cn | China | 283 | 58 |
| Shanghai Jiezhen Pharmaceutical Technology Co., Ltd. | 15995055116 | 815229059@qq.com | China | 166 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Lastest Price from 2,4-dichloro-6-(trifluoromethyl)pyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 2,4-Dichloro-6-trifluoromethylpyrimidine
16097-64-6
|
$2.20-8.80 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-08-20 | 2,4-dichloro-6-(trifluoromethyl)pyrimidine
16097-64-6
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-01-03 | 2,4-dichloro-6-(trifluoromethyl)pyrimidine
16097-64-6
|
$1.00 | 1KG | 99% | 10000KGS | Career Henan Chemical Co |
-
- 2,4-Dichloro-6-trifluoromethylpyrimidine
16097-64-6
- $2.20-8.80
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2,4-dichloro-6-(trifluoromethyl)pyrimidine
16097-64-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2,4-dichloro-6-(trifluoromethyl)pyrimidine
16097-64-6
- $1.00
- 99%
- Career Henan Chemical Co
