Methyl 4,6-dihydroxynicotinate
- CAS No.
- 79398-27-9
- Chemical Name:
- Methyl 4,6-dihydroxynicotinate
- Synonyms
- EOS-61393;4,6-dihydroxynicotinate;Methyl 4,6-dihydroxynicotinate;4,6-Dihydroxy-nicotinic acid methyl ester;Methyl 4,6-dihydroxypyridine-3-carboxylate;methyl 6-hydroxy-4-oxo-1H-pyridine-3-carboxylate;methyl 4-hydroxy-6-oxo-1H-pyridine-3-carboxylate;4,6-Dihydroxy-pyridin-3-carboxylic acid methyl ester;methyl 4-hydroxy-6-oxo-1,6-dihydropyridine-3-carboxylate;Methyl 4,6-dihydroxypyridine-3-carboxylate, 2,4-Dihydroxy-5-(m
- CBNumber:
- CB61459485
- Molecular Formula:
- C7H7NO4
- Molecular Weight:
- 169.13
- MDL Number:
- MFCD09152693
- MOL File:
- 79398-27-9.mol
- MSDS File:
- SDS
| Melting point | 252-255° |
|---|---|
| Boiling point | 331.7±42.0 °C(Predicted) |
| Density | 1.456±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 4.50±1.00(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C7H7NO4/c1-12-7(11)4-3-8-6(10)2-5(4)9/h2-3H,1H3,(H2,8,9,10) |
| InChIKey | YRIXOKHFULWNHE-UHFFFAOYSA-N |
| SMILES | C1NC(=O)C=C(O)C=1C(OC)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P261-P305+P351+P338 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
Methyl 4,6-dihydroxynicotinate price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR46224 | Methyl 4,6-dihydroxynicotinate >98% | 79398-27-9 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR46224 | Methyl 4,6-dihydroxynicotinate >98% | 79398-27-9 | 5g | $78 | 2026-06-04 | Buy |
| Apolloscientific | OR46224 | Methyl 4,6-dihydroxynicotinate >98% | 79398-27-9 | 25g | $317 | 2026-06-04 | Buy |
| Apolloscientific | OR46224 | Methyl 4,6-dihydroxynicotinate >98% | 79398-27-9 | 100g | $1215 | 2026-06-04 | Buy |
| Matrix Scientific | 044647 | Methyl 4,6-dihydroxynicotinate | 79398-27-9 | 5.00g | $84 | 2026-05-18 | Buy |
Methyl 4,6-dihydroxynicotinate Chemical Properties, Uses, Production
Synthesis
1830-54-2
122-51-0
79398-27-9
General procedure for the synthesis of methyl 4,6-dihydroxynicotinate from dimethyl 1,3-acetone dicarboxylate and triethyl orthoformate: dimethyl 1,3-acetone dicarboxylate (2000 g, 11.5 mol), triethyl orthoformate (1947 mL, 11.5 mol), and acetic anhydride (2168 mL, 23.0 mol) were mixed and heated to react for 2 hr at 130°C. The reaction was carried out under vacuum. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under vacuum to a volume of about 1500 mL.The concentrated crude product was cooled in an ice bath and ammonia (2 L) was added slowly with continuous stirring. Thirty minutes after the addition of ammonia, the pH of the mixture was adjusted to acidic with concentrated hydrochloric acid (about 300 mL), followed by filtration to obtain a suspension. The resulting crude product was dried under vacuum to finally obtain methyl 4,6-dihydroxynicotinate (900 g, 46% yield), which can be directly used in the subsequent reaction steps.
References
[1] Patent: US2012/184562, 2012, A1. Location in patent: Page/Page column 6; 17
[2] Patent: CN106854177, 2017, A. Location in patent: Paragraph 0016; 0018; 0024; 0030
[3] Patent: WO2014/210354, 2014, A1. Location in patent: Page/Page column 40
[4] Patent: WO2012/110860, 2012, A1. Location in patent: Page/Page column 98
Methyl 4,6-dihydroxynicotinate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiaxing Rich Biological Technology Co., Ltd. | 0573-11111111-1111 18969316891 | richmol@163.com | China | 446 | 50 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
View Latest Price from Methyl 4,6-dihydroxynicotinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Methyl 4,6-dihydroxynicotinate
79398-27-9
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2023-06-15 | Methyl 4,6-dihydroxynicotinate
79398-27-9
|
$1.00 | 25KG | 99.0% | 3000KG/th | Zibo Shiji Zhonglian Medical Technology Co., Ltd. | |
 |
2020-02-18 | Methyl 4,6-dihydroxynicotinate
79398-27-9
|
$1.00 | 1KG | 99% | 200kgs | Career Henan Chemical Co |
-
- Methyl 4,6-dihydroxynicotinate
79398-27-9
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Methyl 4,6-dihydroxynicotinate
79398-27-9
- $1.00
- 99.0%
- Zibo Shiji Zhonglian Medical Technology Co., Ltd.
-
- Methyl 4,6-dihydroxynicotinate
79398-27-9
- $1.00
- 99%
- Career Henan Chemical Co
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