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Methyl 4,6-dihydroxynicotinate

Methyl 4,6-dihydroxynicotinate structure

CAS No.: 79398-27-9

Chemical Name:: Methyl 4,6-dihydroxynicotinate

Synonyms: EOS-61393;4,6-dihydroxynicotinate;Methyl 4,6-dihydroxynicotinate;4,6-Dihydroxy-nicotinic acid methyl ester;Methyl 4,6-dihydroxypyridine-3-carboxylate;methyl 6-hydroxy-4-oxo-1H-pyridine-3-carboxylate;methyl 4-hydroxy-6-oxo-1H-pyridine-3-carboxylate;4,6-Dihydroxy-pyridin-3-carboxylic acid methyl ester;methyl 4-hydroxy-6-oxo-1,6-dihydropyridine-3-carboxylate;Methyl 4,6-dihydroxypyridine-3-carboxylate, 2,4-Dihydroxy-5-(m

CBNumber:: CB61459485

Molecular Formula:: C7H7NO4

Molecular Weight:: 169.13

MDL Number:: MFCD09152693

MOL File:: 79398-27-9.mol

Last updated:2025-08-08 17:45:00

Product description	Number	Pack Size	Price
methyl4,6-dihydroxynicotinate	M341575	500mg	$240
Methyl4,6-dihydroxynicotinate 99.03%	CS-0061857	10g	$306
METHYL 4,6-DIHYDROXYNICOTINATE 95.00%	CHM0030650	500MG	$683.53
METHYL 4,6-DIHYDROXYNICOTINATE 95.00%	CHM0030650	1G	$722.8
METHYL 4,6-DIHYDROXYNICOTINATE 95.00%	CHM0030650	5G	$1115.96
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Methyl 4,6-dihydroxynicotinate Properties

Melting point	252-255°
Boiling point	331.7±42.0 °C(Predicted)
Density	1.456±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	4.50±1.00(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C7H7NO4/c1-12-7(11)4-3-8-6(10)2-5(4)9/h2-3H,1H3,(H2,8,9,10)
InChIKey	YRIXOKHFULWNHE-UHFFFAOYSA-N
SMILES	C1NC(=O)C=C(O)C=1C(OC)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P261-P305+P351+P338
HazardClass	IRRITANT
HS Code	2933399990

Methyl 4,6-dihydroxynicotinate price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	M341575	methyl4,6-dihydroxynicotinate	79398-27-9	500mg	$240	2021-12-16	Buy
ChemScene	CS-0061857	Methyl4,6-dihydroxynicotinate 99.03%	79398-27-9	10g	$306	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0030650	METHYL 4,6-DIHYDROXYNICOTINATE 95.00%	79398-27-9	500MG	$683.53	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0030650	METHYL 4,6-DIHYDROXYNICOTINATE 95.00%	79398-27-9	1G	$722.8	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0030650	METHYL 4,6-DIHYDROXYNICOTINATE 95.00%	79398-27-9	5G	$1115.96	2021-12-16	Buy

Product number	Packaging	Price	Buy
M341575	500mg	$240	Buy
CS-0061857	10g	$306	Buy
CHM0030650	500MG	$683.53	Buy
CHM0030650	1G	$722.8	Buy
CHM0030650	5G	$1115.96	Buy

Methyl 4,6-dihydroxynicotinate Chemical Properties,Uses,Production

Synthesis

1830-54-2

122-51-0

79398-27-9

General procedure for the synthesis of methyl 4,6-dihydroxynicotinate from dimethyl 1,3-acetone dicarboxylate and triethyl orthoformate: dimethyl 1,3-acetone dicarboxylate (2000 g, 11.5 mol), triethyl orthoformate (1947 mL, 11.5 mol), and acetic anhydride (2168 mL, 23.0 mol) were mixed and heated to react for 2 hr at 130°C. The reaction was carried out under vacuum. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under vacuum to a volume of about 1500 mL.The concentrated crude product was cooled in an ice bath and ammonia (2 L) was added slowly with continuous stirring. Thirty minutes after the addition of ammonia, the pH of the mixture was adjusted to acidic with concentrated hydrochloric acid (about 300 mL), followed by filtration to obtain a suspension. The resulting crude product was dried under vacuum to finally obtain methyl 4,6-dihydroxynicotinate (900 g, 46% yield), which can be directly used in the subsequent reaction steps.

References

[1] Patent: US2012/184562, 2012, A1. Location in patent: Page/Page column 6; 17
[2] Patent: CN106854177, 2017, A. Location in patent: Paragraph 0016; 0018; 0024; 0030
[3] Patent: WO2014/210354, 2014, A1. Location in patent: Page/Page column 40
[4] Patent: WO2012/110860, 2012, A1. Location in patent: Page/Page column 98

Methyl 4,6-dihydroxynicotinate Preparation Products And Raw materials

Raw materials

Dimethyl 1,3-acetonedicarboxylate Triethyl orthoformate Hydrochloric acid Ammonia

Preparation Products

Methyl 4-aMino-6-chloronicotinate 6-Chloro-1H-pyrazolo[4,3-c]pyridine Methyl 4,6-dichloronicotinate

Methyl 4,6-dihydroxynicotinate Suppliers

Global( 123)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	CHINA	4017	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8645	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	58
CR Corporation Limited	58
Labnetwork lnc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from Methyl 4,6-dihydroxynicotinate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-13	Methyl 4,6-dihydroxynicotinate 79398-27-9	US $3.00-9.00 / KG	0.1KG	99%	g-kg-tons, free sample is available	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2023-06-15	Methyl 4,6-dihydroxynicotinate 79398-27-9	US $1.00 / KG	25KG	99.0%	3000KG/th	Zibo Shiji Zhonglian Medical Technology Co., Ltd.
2020-02-18	Methyl 4,6-dihydroxynicotinate 79398-27-9	US $1.00 / KG	1KG	99%	200kgs	Career Henan Chemical Co

Methyl 4,6-dihydroxynicotinate
79398-27-9
US $3.00-9.00 / KG
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Methyl 4,6-dihydroxynicotinate
79398-27-9
US $1.00 / KG
99.0%
Zibo Shiji Zhonglian Medical Technology Co., Ltd.

Methyl 4,6-dihydroxynicotinate
79398-27-9
US $1.00 / KG
99%
Career Henan Chemical Co

Methyl 4,6-dihydroxynicotinate Spectrum

Methyl 4,6-dihydroxynicotinate(79398-27-9)¹HNMR

79398-27-9(Methyl 4,6-dihydroxynicotinate)Related Search:

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Methyl 6-aminonicotinate Methyl 2-methylnicotinate Methylparaben Methyl 3,5-dihydroxybenzoate Methyl acrylate

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1of4

3-Pyridinecarboxylic acid, 1,6-dihydro-4-hydroxy-6-oxo-, Methyl ester Methyl 4,6-dihydroxypyridine-3-carboxylate Methyl 4,6-dihydroxypyridine-3-carboxylate, 2,4-Dihydroxy-5-(methoxycarbonyl)pyridine methyl 4-hydroxy-6-oxo-1,6-dihydropyridine-3-carboxylate 4,6-Dihydroxy-nicotinic acid methyl ester EOS-61393 4,6-dihydroxynicotinate Methyl 4,6-dihydroxypyridine-3-carboxylate, 2,4-Dihydroxy-5-(m methyl 6-hydroxy-4-oxo-1H-pyridine-3-carboxylate Methyl 4,6-dihydroxynicotinate 1,6-dihydro-4-hydroxy-6-oxo-pyridine-3-carboxylic acid methyl ester methyl 4-hydroxy-6-oxo-1H-pyridine-3-carboxylate 4,6-Dihydroxy-pyridin-3-carboxylic acid methyl ester 79398-27-9