Methyl 6-oxo-1,6-dihydro-3-pyridinecarboxylate
- CAS No.
- 66171-50-4
- Chemical Name:
- Methyl 6-oxo-1,6-dihydro-3-pyridinecarboxylate
- Synonyms
- METHYL 6-HYDROXYNICOTINATE;METHYL 6-OXO-1,6-DIHYDROPYRIDINE-3-CARBOXYLATE;Methyl 6-hydroxypyridine-3-carboxylate;Nicorandil Impurity P;Methyl6-hydroxynicotinate98%;Methyl6-Hydroxynicotinate>Methyl 6-hydroxynicotinate 98%;6-Hydroxynicotinate Methyl ester;Methylpyridin-2-one-5-carboxylate;5-METHOXYCARBONYL-2(1H)-PYRIDINONE
- CBNumber:
- CB0733629
- Molecular Formula:
- C7H7NO3
- Molecular Weight:
- 153.14
- MDL Number:
- MFCD08436011
- MOL File:
- 66171-50-4.mol
- MSDS File:
- SDS
| Melting point | 166-170°C |
|---|---|
| Boiling point | 342.4±42.0 °C(Predicted) |
| Density | 1.263±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 9.99±0.10(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C7H7NO3/c1-11-7(10)5-2-3-6(9)8-4-5/h2-4H,1H3,(H,8,9) |
| InChIKey | JTVVPKLHKMKWNN-UHFFFAOYSA-N |
| SMILES | C1NC(=O)C=CC=1C(OC)=O |
| CAS DataBase Reference | 66171-50-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
| Hazard Codes | Xi |
| Hazard Note | Irritant/Keep Cold |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
Methyl 6-oxo-1,6-dihydro-3-pyridinecarboxylate price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2727 | Methyl 6-Hydroxynicotinate >97.0%(GC) | 66171-50-4 | 1g | $34 | 2026-04-30 | Buy |
| TCI Chemical | M2727 | Methyl 6-Hydroxynicotinate >97.0%(GC) | 66171-50-4 | 5g | $133 | 2026-04-30 | Buy |
| AstaTech | 62440 | 6-HYDROXY-NICOTINIC ACID METHYL ESTER 97% | 66171-50-4 | 5G | $29 | 2026-04-30 | Buy |
| AstaTech | 62440 | 6-HYDROXY-NICOTINIC ACID METHYL ESTER 97% | 66171-50-4 | 25G | $69 | 2026-04-30 | Buy |
| Apolloscientific | OR9557 | Methyl 6-hydroxynicotinate 98% | 66171-50-4 | 5g | $28 | 2026-06-04 | Buy |
Methyl 6-oxo-1,6-dihydro-3-pyridinecarboxylate Chemical Properties,Uses,Production
Synthesis Reference(s)
Journal of the American Chemical Society, 104, p. 1428, 1982 DOI: 10.1021/ja00369a049
Organic Syntheses, Coll. Vol. 4, p. 532, 1963
Synthesis
67-56-1
5006-66-6
66171-50-4
General procedure for the synthesis of methyl 6-hydroxynicotinate from methanol and 6-hydroxynicotinic acid: first, 6-hydroxynicotinic acid (100 g, 719 mmol) was suspended in methanol (1 L). Subsequently, 18 M sulfuric acid (50 mL) was added and the reaction mixture was heated to reflux for 16 hours. Upon completion of the reaction, the reaction mixture was cooled and sodium bicarbonate powder (45 g) was slowly added to partially neutralize the acidity. Next, most of the methanol was evaporated under reduced pressure. Water (1 L) was added to the residue and the pH was adjusted to 7 by careful addition of sodium bicarbonate solution. the suspension was extracted with dichloromethane (4 x 200 mL), the organic phases were combined and dried over anhydrous sodium sulfate. After removing the solvent under reduced pressure, the resulting solid was dried in a vacuum oven at 50 °C for 1.5 h to give 83 g (75% yield) of methyl 6-hydroxynicotinate as a white solid. Mass spectrum (electrospray ionization): 154.2 (MH+, C7H7NO3). 1H NMR (300 MHz, CDCl3): δ 3.88 (s, 3H), 6.59 (dd, 1H), 8.02 (dd, 1H), 8.21 (m, 1H), 13.19 (bs, 1H).
References
[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 15, p. 6679 - 6703
[2] Patent: WO2012/52444, 2012, A1. Location in patent: Page/Page column 12
[3] Chemistry - A European Journal, 2009, vol. 15, # 24, p. 5950 - 5955
[4] Patent: WO2009/106885, 2009, A1. Location in patent: Page/Page column 296
[5] Organic and Biomolecular Chemistry, 2010, vol. 8, # 15, p. 3534 - 3542
Methyl 6-oxo-1,6-dihydro-3-pyridinecarboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong Flying Pharmtech Co., Ltd. | 13270692087 | 2488110388@qq.com | China | 32 | 58 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
| Shanghai Diluo Technology Co., LTD | 19279824758 19526192903 | 15106284752@163.com | China | 175 | 58 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 |
View Lastest Price from Methyl 6-oxo-1,6-dihydro-3-pyridinecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE
66171-50-4
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2021-08-12 | METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE
66171-50-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-12-23 | Methyl 6-hydroxynicotinate
66171-50-4
|
$2.00 | 1KG | ≥98% | 100kg | Career Henan Chemical Co |
-
- METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE
66171-50-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE
66171-50-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Methyl 6-hydroxynicotinate
66171-50-4
- $2.00
- ≥98%
- Career Henan Chemical Co
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