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ChemicalBook >> CAS DataBase List >>H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH

H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH

H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH Structure
H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH structure
CAS No.
249537-73-3
Chemical Name:
H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH
Synonyms
VIVIT;NFAT INHIBITOR;NFAT Inhibitor-1;MAGPHPVIVITGPHEE;NFAT INHIBITOR?, >98%;NFAT Inhibitor (VIVIT peptide);NFAT Inhibitor >96% (HPLC), solid;NFAT Inhibitor，VIVIT peptide，MAGPHPVIVITGPHEE;NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98%;MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU
CBNumber:
CB6148948
Molecular Formula:
C75H118N20O22S
Molecular Weight:
1683.93
MDL Number:
MFCD02683959
MOL File:
249537-73-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:53:53
Request For Quotation

H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH Properties

Boiling point 1982.4±65.0 °C(Predicted)
Density 1.334±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: 15 mg/ml; Water: 10 mg/ml
form solid
pka 3.12±0.10(Predicted)
color White to off-white
Water Solubility Soluble to 2 mg/ml in water
Sequence H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH
InChIKey QPMHUXBSHGAVGD-MCDIZDEASA-N
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  22-24/25
WGK Germany  3
HS Code  2933299090
Storage Class 11 - Combustible Solids

H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N7032 NFAT Inhibitor >96% (HPLC), solid 249537-73-3 1MG $668 2026-04-30 Buy
Sigma-Aldrich 480402 NFAT Inhibitor The NFAT Inhibitor controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. 500μG $155 2026-04-30 Buy
Cayman Chemical 13855 NFAT Inhibitor ≥95% 249537-73-3 1mg $91 2026-04-30 Buy
Cayman Chemical 13855 NFAT Inhibitor ≥95% 249537-73-3 5mg $399 2026-04-30 Buy
Cayman Chemical 13855 NFAT Inhibitor ≥95% 249537-73-3 10mg $707 2026-04-30 Buy
Product number Packaging Price Buy
N7032 1MG $668 Buy
480402 500μG $155 Buy
13855 1mg $91 Buy
13855 5mg $399 Buy
13855 10mg $707 Buy

H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH Chemical Properties, Uses, Production

Description

NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. At 100 μM, this inhibitor effectively blocks calcineurin binding to NFAT without disrupting other calcineurin-dependent pathways, unlike the immunosuppressants cyclosporin A and FK506 which indiscriminately block all calcineurin phosphatase activity. NFAT inhibitor can disrupt NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and can prevent the activation and proliferation of T cells both in vitro (~ 43% at 1 μM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice).

Uses

NFAT Inhibitor, VIVIT has been used to study the signaling pathways involved in controlling inhibitory molecules and subsequent onset of T-cell impairment.

Biochem/physiol Actions

High-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

storage

Store at -20°C

References

[1] JOSE ARAMBURU. Affinity-Driven Peptide Selection of an NFAT Inhibitor More Selective Than Cyclosporin A[J]. Science, 1999, 285 5436. DOI: 10.1126/science.285.5436.2129
[2] MICHAEL H A ROEHRL. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 20: 7554-7559. DOI: 10.1073/pnas.0401835101
[3] HAIXIANG YU. Therapeutic potential of a synthetic peptide inhibitor of nuclear factor of activated T cells as antirestenotic agent.[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2006, 26 7: 1531-1537. DOI: 10.1161/01.atv.0000225286.30710.af
[4] XUEQIANG ZHAO. JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression[J]. Nature Medicine, 2017, 23 3: 337-346. DOI: 10.1038/nm.4260

H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH Preparation Products And Raw materials

Raw materials

Preparation Products

H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH Suppliers

Global Suppliers ( 117)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Hangzhou Peptide Biochem Co.,Ltd 0571-89197072; 18668118770 linda@peptide-china.com China 233 56
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Creative Peptides info@creative-peptides.com United States 6083 56
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
GL Biochem (Shanghai) Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
MedChemexpress LLC 58
Bide Pharmatech Ltd. 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Hangzhou Peptide Biochem Co.,Ltd 56
Sigma-Aldrich 80
Creative Peptides 56

View Latest Price from H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NFAT Inhibitor pictures 2026-07-21 NFAT Inhibitor
249537-73-3
 $68.00-477.00 99.00% 10g TargetMol Chemicals Inc.
H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH pictures 2026-06-30 H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
249537-73-3
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH pictures 2020-02-17 H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
249537-73-3
 $7.00 1KG 99% 100KG Career Henan Chemical Co

H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH Spectrum

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH(249537-73-3)MS

249537-73-3 (H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH) Related Search:

H-Glu-Glu-OH H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH H-Pro-His-Val-OH Oligopeptide-74 HSDVHK-NH2
L-Proline, L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-, acetate (1:1) Nfat Inhibitor

1of2

MAGPHPVIVITGPHEE MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU NFAT INHIBITOR NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98% NFAT INHIBITOR?, >98% NFAT Inhibitor (VIVIT peptide) L-Glutamic acid, L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl- NFAT Inhibitor >96% (HPLC), solid L-Methionyl-L-Alanylglycyl-L-Prolyl-L-Histidyl-L-Prolyl-L-Valyl-L-Isoleucyl-L-Valyl-L-Isoleucyl-L-Threonylglycyl-L-Prolyl-L-Histidyl-L-alpha-Glutamyl-L-Glutamic Acid NFAT Inhibitor-1 N-L-Methionyl-L-alanylglycyl-L-prolyl-L-histidyl-N-ethyl-L-alanyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-glutamyl-L-glutamic acid NFAT Inhibitor，VIVIT peptide，MAGPHPVIVITGPHEE VIVIT H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH 249537-73-3 C75H118N20O22S BioChemical Cell Signaling and Neuroscience Cell Biology Gene Regulation and Expression Gene Regulation Gene Regulation Cell Signaling and Neuroscience Gene Regulation and Expression