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ChemicalBook >> CAS DataBase List >>4-Amino-2,6-dichloropyridine

4-Amino-2,6-dichloropyridine

4-Amino-2,6-dichloropyridine Structure
4-Amino-2,6-dichloropyridine structure
CAS No.
2587-02-2
Chemical Name:
4-Amino-2,6-dichloropyridine
Synonyms
2,6-DICHLOROPYRIDIN-4-AMINE;2,6-DICHLORO-PYRIDIN-4-YLAMINE;2,6-dichloro-4-pyridinamine;2,6-DICHLORO-4-AMINOPYRIDINE;2,6-Dichloropyridine-4-amine;0/2/87;NSC 136573;AURORA KA-3022;4-Amino-2,6-dichL;6-Dichloro-4-pyridinamine
CBNumber:
CB6151104
Molecular Formula:
C5H4Cl2N2
Molecular Weight:
163
MDL Number:
MFCD00052832
MOL File:
2587-02-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:15:38
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4-Amino-2,6-dichloropyridine Properties

Melting point 169-173 °C (lit.)
Boiling point 336.7±37.0 °C(Predicted)
Density 1.497±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Powder
pka 0.49±0.50(Predicted)
color White to buff
BRN 114351
InChI InChI=1S/C5H4Cl2N2/c6-4-1-3(8)2-5(7)9-4/h1-2H,(H2,8,9)
InChIKey WAEZOSSWRXDWAX-UHFFFAOYSA-N
SMILES C1(Cl)=NC(Cl)=CC(N)=C1
CAS DataBase Reference 2587-02-2(CAS DataBase Reference)
NIST Chemistry Reference Pyridine, 4-amino-2,6-dichloro-(2587-02-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
HazardClass  IRRITANT
HS Code  29333990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

4-Amino-2,6-dichloropyridine price More Price(96)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 565342 4-Amino-2,6-dichloropyridine 97% 2587-02-2 5g $69.7 2026-04-30 Buy
TCI Chemical A2369 4-Amino-2,6-dichloropyridine >97.0%(GC)(N) 2587-02-2 1g $34 2026-04-30 Buy
TCI Chemical A2369 4-Amino-2,6-dichloropyridine >97.0%(GC)(N) 2587-02-2 5g $104 2026-04-30 Buy
Usbiological A1376-95 4-Amino-2,6-dichloropyridine 5g $333 2026-06-03 Buy
Usbiological 232771 4-Amino-2,6-dichloropyridine 98+% ≥98% 2587-02-2 1g $167 2026-06-03 Buy
Product number Packaging Price Buy
565342 5g $69.7 Buy
A2369 1g $34 Buy
A2369 5g $104 Buy
A1376-95 5g $333 Buy
232771 1g $167 Buy

4-Amino-2,6-dichloropyridine Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

4-Amino-2,6-dichloropyridine is a compound useful in organic synthesis used in the synthesis of Rho kinase inhibitors.

Application

4-Amino-2,6-dichloropyridine has wide applications in the pharmaceutical field. Because its molecule contains amino and chlorine atoms, it can interact with a variety of biomolecules, thus serving as a raw material for the synthesis of many drugs. For example, it can be used to synthesize certain antibiotics, anticancer drugs, and antiviral drugs. These drugs play an important role in the treatment of many diseases.

Synthesis

2 6-DICHLORO-4-NITROPYRIDINE 97

25194-01-8

4-Amino-2,6-dichloropyridine

2587-02-2

The general procedure for the synthesis of 4-amino-2,6-dichloropyridine from 2,6-dichloro-4-nitropyridine was as follows: to a solution of 2,6-dichloro-4-nitropyridine (14.82 g, 76.79 mmol) in ethanol (350 mL) was added sequentially iron powder (19.91 g, 356.58 mmol), water (65.8 mL, 3.6 mol), and concentrated hydrochloric acid (14.1 mL, 464.1 mmol). The reaction was carried out at 95 °C with stirring for 16 hours. After completion of the reaction, the reaction solution was cooled to room temperature and the pH was adjusted to neutral. After filtration, the filtrate was concentrated and extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, and the solvent was removed by rotary evaporation to afford 11.9 g of the title product 4-amino-2,6-dichloropyridine in 95.1% yield.

References

[1] Patent: US2012/289497, 2012, A1. Location in patent: Page/Page column 51-52
[2] Patent: EP2524917, 2012, A1. Location in patent: Page/Page column 58-59
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 3, p. 1511 - 1530
[4] Nucleosides, Nucleotides and Nucleic Acids, 2003, vol. 22, # 12, p. 2133 - 2144
[5] ChemCatChem, 2016, vol. 8, # 8, p. 1485 - 1489

4-Amino-2,6-dichloropyridine Preparation Products And Raw materials

Raw materials

2,6-Dichloropyridine Ethanol Acetone Hydrogen peroxide Sodium sulfate
Potassium carbonate Trifluoroacetic acid Chloroform Phosphorus trichloride Diethyl ether
Kieserite Ethyl acetate Hydrochloric acid Nitric acid Acetic acid
Iron Sulfuric acid Sodium carbonate

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Preparation Products

4-Amino-2,6-dichloropyridine Suppliers

Global( 367)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuxi Kehua Biological Technology Co., Ltd. 13636419861 13636419861 alan@covapharm.com China 272 58
Aikon International Limited 025-58851090 13913916777 sales01@aikonchem.com China 15947 58
Shanghai Taijilin Industrial Co., Ltd. 02150630626 17717886015 kate@tajilin.com China 1340 58
Record Tech (Shanghai) Co., LTD 13761627472 183009664@qq.com China 661 62
Tongchuang Pharma(Suzhou). Co., Ltd. 0512-63263366 18912765016 tongtf110@sina.com China 984 62
Fengcheng Meditech (Tianjin)Co., Ltd 022-59002498-8008; 15122574756 info@fcmeditech.com China 83 58
Deyang haijungang Technology Co., Ltd 15883665058 dyhjgkj@126.com China 555 58
Anhui Dexinjia Biopharm Co., Ltd., 0531-82375887 18245291386 3955164757@qq.com China 47 58
Nanbu County Chengxin Technology Co., Ltd. 0838-5675166 15883665058 nbcxkj@126.com China 956 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
Wuxi Kehua Biological Technology Co., Ltd. 58
Aikon International Limited 58
Shanghai Taijilin Industrial Co., Ltd. 58
Record Tech (Shanghai) Co., LTD 62
Tongchuang Pharma(Suzhou). Co., Ltd. 62
Fengcheng Meditech (Tianjin)Co., Ltd 58
Deyang haijungang Technology Co., Ltd 58
Anhui Dexinjia Biopharm Co., Ltd., 58
Nanbu County Chengxin Technology Co., Ltd. 55
J & K SCIENTIFIC LTD. 76

View Lastest Price from 4-Amino-2,6-dichloropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Amino-2,6-dichloropyridine pictures 2026-09-11 4-Amino-2,6-dichloropyridine
2587-02-2
 1kg 99 Hangzhou Lucky Biology Co., Ltd
4-Amino-2,6-dichloropyridine pictures 2026-07-30 4-Amino-2,6-dichloropyridine
2587-02-2
 98% 10MT per month Anhui Dexinjia Biopharm Co., Ltd
4-Amino-2,6-dichloropyridine pictures 2026-06-30 4-Amino-2,6-dichloropyridine
2587-02-2
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd

4-Amino-2,6-dichloropyridine Spectrum

4-Amino-2,6-dichloropyridine(2587-02-2)1HNMR4-Amino-2,6-dichloropyridine(2587-02-2)FT-IR

2587-02-2(4-Amino-2,6-dichloropyridine)Related Search:

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4-Amino-2,6-dichloropyridine, 98+% 4-Amino-2,6-dichloropyridine ,97% (4-AMino-2,6-dichloropyridine)4-AMino-2,6-dichloropyridine NSC 136573 4- aMino-2,6- twochlorine pyridine 4-AMino-2,6-dichloropyridine 97% 4-AMino-2,6-dichloropyridine, 97.5% 2,6-DICHLORO-4-AMINOPYRIDINE 2,6-DICHLORO-PYRIDIN-4-YLAMINE 4-Pyridinamine, 2,6-dichloro- 4-AMINO-2,6-DICHLOROPYRIDINE AURORA KA-3022 2,6-dichloro-4-pyridinamine 4-Ami-2,6-dichloropyridine 4-Amino-2,6-dichloropyridine > 4-Amino-2,6-dichL 4-Amino-2,6-dichloropyridine ISO 9001：2015 REACH 4-amino-2,6-dichloropyridine-2587-02-2 6-Dichloro-4-pyridinamine 0/2/87 2,6-Dichloropyridine-4-amine 98% 2,6-Dichloropyridine-4-amine 2,6-DICHLOROPYRIDIN-4-AMINE 2587-02-2 2587-2-2 2/2/2587 2687-02-2 2587-02-0 2587/2/2 Heterocyclic Building Blocks Halogenated Heterocycles Pyridines Building Blocks Building Blocks C5 C5 to C6 Chemical Synthesis Nucleotides and Nucleosides Bases & Related Reagents Nucleotides Amines Aromatics Heterocycles Pyridine Heterocycle-Pyridine series Halogenated Heterocycles Heterocyclic Building Blocks Pyridines