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4-Amino-2,6-dichloropyridine

4-Amino-2,6-dichloropyridine Structure
4-Amino-2,6-dichloropyridine structure
CAS No.
2587-02-2
Chemical Name:
4-Amino-2,6-dichloropyridine
Synonyms
2,6-DICHLOROPYRIDIN-4-AMINE;2,6-DICHLORO-PYRIDIN-4-YLAMINE;2,6-dichloro-4-pyridinamine;2,6-DICHLORO-4-AMINOPYRIDINE;0/2/87;NSC 136573;AURORA KA-3022;4-Amino-2,6-dichL;6-Dichloro-4-pyridinamine;4-Ami-2,6-dichloropyridine
CBNumber:
CB6151104
Molecular Formula:
C5H4Cl2N2
Molecular Weight:
163
MDL Number:
MFCD00052832
MOL File:
2587-02-2.mol
MSDS File:
SDS
Last updated:2026-01-24 17:36:03
Product description Number Pack Size Price
4-Amino-2,6-dichloropyridine 97% 565342 5g $65.4
4-Amino-2,6-dichloropyridine >97.0%(GC)(N) A2369 1g $40
4-Amino-2,6-dichloropyridine >97.0%(GC)(N) A2369 5g $122
4-Amino-2,6-dichloropyridine A604710 5g $60
4-Amino-2,6-dichloropyridine A604710 10g $95
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4-Amino-2,6-dichloropyridine Properties

Melting point 169-173 °C (lit.)
Boiling point 336.7±37.0 °C(Predicted)
Density 1.497±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka 0.49±0.50(Predicted)
form Powder
color White to buff
BRN 114351
InChI InChI=1S/C5H4Cl2N2/c6-4-1-3(8)2-5(7)9-4/h1-2H,(H2,8,9)
InChIKey WAEZOSSWRXDWAX-UHFFFAOYSA-N
SMILES C1(Cl)=NC(Cl)=CC(N)=C1
CAS DataBase Reference 2587-02-2(CAS DataBase Reference)
NIST Chemistry Reference Pyridine, 4-amino-2,6-dichloro-(2587-02-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
HazardClass  IRRITANT
HS Code  29333990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

4-Amino-2,6-dichloropyridine price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 565342 4-Amino-2,6-dichloropyridine 97% 2587-02-2 5g $65.4 2025-07-31 Buy
TCI Chemical A2369 4-Amino-2,6-dichloropyridine >97.0%(GC)(N) 2587-02-2 1g $40 2025-07-31 Buy
TCI Chemical A2369 4-Amino-2,6-dichloropyridine >97.0%(GC)(N) 2587-02-2 5g $122 2025-07-31 Buy
TRC A604710 4-Amino-2,6-dichloropyridine 2587-02-2 5g $60 2021-12-16 Buy
TRC A604710 4-Amino-2,6-dichloropyridine 2587-02-2 10g $95 2021-12-16 Buy
Product number Packaging Price Buy
565342 5g $65.4 Buy
A2369 1g $40 Buy
A2369 5g $122 Buy
A604710 5g $60 Buy
A604710 10g $95 Buy

4-Amino-2,6-dichloropyridine Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

4-Amino-2,6-dichloropyridine is a compound useful in organic synthesis used in the synthesis of Rho kinase inhibitors.

Application

4-Amino-2,6-dichloropyridine has wide applications in the pharmaceutical field. Because its molecule contains amino and chlorine atoms, it can interact with a variety of biomolecules, thus serving as a raw material for the synthesis of many drugs. For example, it can be used to synthesize certain antibiotics, anticancer drugs, and antiviral drugs. These drugs play an important role in the treatment of many diseases.

Synthesis

2 6-DICHLORO-4-NITROPYRIDINE 97

25194-01-8

4-Amino-2,6-dichloropyridine

2587-02-2

The general procedure for the synthesis of 4-amino-2,6-dichloropyridine from 2,6-dichloro-4-nitropyridine was as follows: to a solution of 2,6-dichloro-4-nitropyridine (14.82 g, 76.79 mmol) in ethanol (350 mL) was added sequentially iron powder (19.91 g, 356.58 mmol), water (65.8 mL, 3.6 mol), and concentrated hydrochloric acid (14.1 mL, 464.1 mmol). The reaction was carried out at 95 °C with stirring for 16 hours. After completion of the reaction, the reaction solution was cooled to room temperature and the pH was adjusted to neutral. After filtration, the filtrate was concentrated and extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, and the solvent was removed by rotary evaporation to afford 11.9 g of the title product 4-amino-2,6-dichloropyridine in 95.1% yield.

References

[1] Patent: US2012/289497, 2012, A1. Location in patent: Page/Page column 51-52
[2] Patent: EP2524917, 2012, A1. Location in patent: Page/Page column 58-59
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 3, p. 1511 - 1530
[4] Nucleosides, Nucleotides and Nucleic Acids, 2003, vol. 22, # 12, p. 2133 - 2144
[5] ChemCatChem, 2016, vol. 8, # 8, p. 1485 - 1489

4-Amino-2,6-dichloropyridine Preparation Products And Raw materials

Raw materials

2,6-Dichloropyridine Ethanol Acetone Hydrogen peroxide Sodium sulfate
Potassium carbonate Trifluoroacetic acid Chloroform Phosphorus trichloride Diethyl ether
Kieserite Ethyl acetate Hydrochloric acid Nitric acid Acetic acid
Iron Sulfuric acid Sodium carbonate

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Preparation Products

4-Amino-2,6-dichloropyridine Suppliers

Global( 368)Suppliers
Supplier Tel Email Country ProdList Advantage
Anhui Dexinjia Biopharm Co., Ltd 		+86-531-82375818 +86-15064153060 sales01@jndxj.com China 316 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13676 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29831 58
Win-Win Chemical CO., Limited 		0086-577-64498589 sales@win-winchemical.com CHINA 998 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10405 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Supplier Advantage
Anhui Dexinjia Biopharm Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Win-Win Chemical CO., Limited 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58

View Lastest Price from 4-Amino-2,6-dichloropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Amino-2,6-dichloropyridine pictures 2026-02-06 4-Amino-2,6-dichloropyridine
2587-02-2
 US $0.00-0.00 / KG 0.1KG 98% 10MT per month Anhui Dexinjia Biopharm Co., Ltd
4-Amino-2,6-dichloropyridine pictures 2025-12-01 4-Amino-2,6-dichloropyridine
2587-02-2
 US $0.00 / kg 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
4-Amino-2,6-dichloropyridine pictures 2025-11-18 4-Amino-2,6-dichloropyridine
2587-02-2
 US $1.10 / g 1g 99.00% 100 Tons min Dideu Industries Group Limited

4-Amino-2,6-dichloropyridine Spectrum

4-Amino-2,6-dichloropyridine(2587-02-2)1HNMR4-Amino-2,6-dichloropyridine(2587-02-2)FT-IR

2587-02-2(4-Amino-2,6-dichloropyridine)Related Search:

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2,6-Dichloropyridine-4-amine 4-Amino-2,6-dichloropyridine, 98+% 4-Amino-2,6-dichloropyridine ,97% (4-AMino-2,6-dichloropyridine)4-AMino-2,6-dichloropyridine NSC 136573 4- aMino-2,6- twochlorine pyridine 4-AMino-2,6-dichloropyridine 97% 4-AMino-2,6-dichloropyridine, 97.5% 2,6-DICHLORO-4-AMINOPYRIDINE 2,6-DICHLOROPYRIDIN-4-AMINE 2,6-DICHLORO-PYRIDIN-4-YLAMINE 4-Pyridinamine, 2,6-dichloro- 4-AMINO-2,6-DICHLOROPYRIDINE AURORA KA-3022 2,6-dichloro-4-pyridinamine 4-Ami-2,6-dichloropyridine 4-Amino-2,6-dichloropyridine > 4-Amino-2,6-dichL 4-Amino-2,6-dichloropyridine ISO 9001：2015 REACH 4-amino-2,6-dichloropyridine-2587-02-2 6-Dichloro-4-pyridinamine 0/2/87 2,6-Dichloropyridine-4-amine 98% 2587-02-2 2587-2-2 2/2/2587 2687-02-2 2587-02-0 2587/2/2 Heterocyclic Building Blocks Halogenated Heterocycles Pyridines Building Blocks Building Blocks C5 C5 to C6 Chemical Synthesis Nucleotides and Nucleosides Bases & Related Reagents Nucleotides Amines Aromatics Heterocycles Pyridine Heterocycle-Pyridine series Halogenated Heterocycles Heterocyclic Building Blocks Pyridines