Tetrahydro-5-oxo-2- furancarboxyli
- CAS No.
- 4344-84-7
- Chemical Name:
- Tetrahydro-5-oxo-2- furancarboxyli
- Synonyms
- Carboxybutyrolactone;5-oxooxolane-2-carboxylicaci;Butyrolactonecarboxylic acid;alpha-Hydroxyglutaryl lactone;5-Oxooxolane-2-carboxylic acid;Tetrahydro-5-oxo-2-furoic acid;5-oxo-2-tetrahydrofuranoic acid;Tetrahydro-5-oxo-2-furancarboxyl;etrahydro-5-oxo-2- furancarboxyli;Tetrahydro-5-oxo-2- furancarboxyli
- CBNumber:
- CB61512711
- Molecular Formula:
- C5H6O4
- Molecular Weight:
- 130.1
- MDL Number:
- MFCD00066678
- MOL File:
- 4344-84-7.mol
- MSDS File:
- SDS
| Melting point | 48-50 °C |
|---|---|
| Boiling point | 116-118 °C(Press: 1.5 Torr) |
| Density | 1.469±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Water (Sparingly) |
| form | Solid |
| pka | 3.11±0.20(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C5H6O4/c6-4-2-1-3(9-4)5(7)8/h3H,1-2H2,(H,7,8) |
| InChIKey | QVADRSWDTZDDGR-UHFFFAOYSA-N |
| SMILES | O1C(=O)CCC1C(O)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
Tetrahydro-5-oxo-2- furancarboxyli price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | EAA34484 | 5-Oxotetrahydrofuran-2-carboxylic acid | 4344-84-7 | 100g | $250 | 2026-06-04 | Buy |
| Synthonix | X38776 | 5-Oxotetrahydrofuran-2-carboxylic acid 95+% | 4344-84-7 | 250mg | $19 | 2026-05-06 | Buy |
| Synthonix | X38776 | 5-Oxotetrahydrofuran-2-carboxylic acid 95+% | 4344-84-7 | 1g | $23 | 2026-05-06 | Buy |
| Synthonix | X38776 | 5-Oxotetrahydrofuran-2-carboxylic acid 95+% | 4344-84-7 | 5g | $25 | 2026-05-06 | Buy |
| Synthonix | X38776 | 5-Oxotetrahydrofuran-2-carboxylic acid 95+% | 4344-84-7 | 10g | $30 | 2026-05-06 | Buy |
Tetrahydro-5-oxo-2- furancarboxyli Chemical Properties, Uses, Production
Uses
Carboxybutyrolactone is a structural analog of (±)-Paraconic Acid (P191200) and is used as a reagent in the synthesis of methylenecarboxybutyrolactones which have antibacterial activity.
Definition
ChEBI: 5-oxotetrahydrofuran-2-carboxylic acid is a gamma-lactone resulting from the formal intramolecular condensation of the alcoholic hydroxy group of 2-hydroxyglutaric acid with the carboxy group at position 5. It is a gamma-lactone and a monocarboxylic acid.
Synthesis
617-65-2
4344-84-7
The general procedure for the synthesis of tetrahydro-5-oxo-2-furancarboxylic acid from 2-aminoglutaric acid is as follows: (1) 140 mL of concentrated hydrochloric acid was slowly added to a solution containing compound 1 (2-aminoglutaric acid, 270 mL of water as solvent) at room temperature and protected by nitrogen, and exothermic phenomena were observed. After the system became clear, it was cooled to 0°C. 70.3 g of sodium nitrite (dissolved in 200 mL of water) was slowly added to the system at 0°C, taking care to control the temperature. The system gradually turned green and turbid, and the dosing process continued for 15 minutes, keeping the temperature at about 2°C. The system was cooled to 0°C. After completion of the dropwise addition, the reaction was continued at 0°C. Subsequently, the reaction solution was concentrated directly to dryness at 50°C using an oil pump. The concentrated dry mass was pulped with 400 mL of ethyl acetate and filtered. The filter cake was again pulped once with 400 mL of ethyl acetate and then the cake was washed with 200 mL of ethyl acetate. All filtrates were combined and dried by pump at 45°C to give a final 104 g of yellow oily liquid (Compound 2).
References
[1] Chemische Berichte, 1961, vol. 94, p. 2106 - 2114
[2] Chemistry and Industry (London, United Kingdom), 1959, p. 1413
[3] Justus Liebigs Annalen der Chemie, 1890, vol. 260, p. 128
[4] Patent: CN106748972, 2017, A. Location in patent: Paragraph 0022; 0023; 0024; 0030
Tetrahydro-5-oxo-2- furancarboxyli Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dtchem Laboratories,（Gan Su）Co.,Ltd. | 18993961550 18993966060 | sales@techbiochem.com | China | 773 | 61 |
| Tianjin Branch Chong pharmaceutical intermediates Co., Ltd. | 022-60116533 13207668525 | saleskc@scipharmacn.com | China | 360 | 58 |
| TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. | 022-60189726 18812034280 | 188120342808@163.com | China | 143 | 61 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from Tetrahydro-5-oxo-2- furancarboxyli manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 5-Oxotetrahydrofuran-2-carboxylic acid
4344-84-7
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2025-04-04 | Tetrahydro-5-oxo-2- furancarboxylic acid
4344-84-7
|
$5.00 | 1g | 97% | 100kg | Henan Aochuang Chemical Co.,Ltd. | |
 |
2023-10-08 | Tetrahydro-5-oxo-2- furancarboxyli
4344-84-7
|
$30.00 | 1KG | 99% | 20T | Firsky International Trade (Wuhan) Co., Ltd |
-
- 5-Oxotetrahydrofuran-2-carboxylic acid
4344-84-7
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- Tetrahydro-5-oxo-2- furancarboxylic acid
4344-84-7
- $5.00
- 97%
- Henan Aochuang Chemical Co.,Ltd.
-
- Tetrahydro-5-oxo-2- furancarboxyli
4344-84-7
- $30.00
- 99%
- Firsky International Trade (Wuhan) Co., Ltd
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