2,6-Pyridinedimethanol
- CAS No.
- 1195-59-1
- Chemical Name:
- 2,6-Pyridinedimethanol
- Synonyms
- pyridine-2,6-diyldimethanol;PYRIDINE-2,6-DIMETHANOL;2,6-BIS(HYDROXYMETHYL)PYRIDINE;(6-Hydroxymethyl-pyridin-2-yl)-methanol;2,6-PYRIDINETHANOL;2,6-PYRIDINEMETHANOL BIS;2,6-Pyridinedimethanol ,98%;2,6-PyridinediMethanol, 98% 5GR;2,6-PyridinediMethanol SynonyMs 2,6-Pyridyldicarbinol;RARECHEM AL BD 0203
- CBNumber:
- CB6168050
- Molecular Formula:
- C7H9NO2
- Molecular Weight:
- 139.15
- MDL Number:
- MFCD00006351
- MOL File:
- 1195-59-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 112-114 °C (lit.) |
|---|---|
| Boiling point | 185°C 15mm |
| Density | 1.1997 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| Flash point | 185°C/15mm |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 13.03±0.10(Predicted) |
| form | Crystalline Powder |
| color | Light yellow to beige |
| Water Solubility | Soluble in water. |
| BRN | 116016 |
| InChI | InChI=1S/C7H9NO2/c9-4-6-2-1-3-7(5-10)8-6/h1-3,9-10H,4-5H2 |
| InChIKey | WWFMINHWJYHXHF-UHFFFAOYSA-N |
| SMILES | C1(CO)=NC(CO)=CC=C1 |
| CAS DataBase Reference | 1195-59-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyridine, 2,6-dicarbinol(1195-59-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37/38-41-36/37/38 | |||||||||
| Safety Statements | 26-39-24/25-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 23 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29333999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2,6-Pyridinedimethanol price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 154369 | 2,6-Pyridinedimethanol 98% | 1195-59-1 | 5g | $42.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 154369 | 2,6-Pyridinedimethanol 98% | 1195-59-1 | 25g | $144 | 2026-04-30 | Buy |
| TCI Chemical | P0803 | 2,6-Pyridinedimethanol >98.0%(GC)(T) | 1195-59-1 | 5g | $59 | 2026-04-30 | Buy |
| TCI Chemical | P0803 | 2,6-Pyridinedimethanol >98.0%(GC)(T) | 1195-59-1 | 25g | $213 | 2026-04-30 | Buy |
| Usbiological | 287361 | 2,6-Pyridinedimethanol Asreported | 1195-59-1 | 5g | $333 | 2026-06-03 | Buy |
2,6-Pyridinedimethanol Chemical Properties,Uses,Production
Chemical Properties
light yellow to beige crystalline powder
Uses
2,6-Pyridinedimethanol can be used as a quantum dot solution for photoelectric device and biomedicine and also a ligand to synthesize a variety of metal complexes and catalysts.
Preparation
The preparation of 2,6-Pyridinedimethanol is as follows:2640g of 2,6-dibromomethylpyridine, 3L of 30% aqueous sodium hydroxide solution, and 10L of ethanol were placed in a 20L reaction flask. Turn on the agitation. The reaction solution was heated to reflux and the reaction was kept for 5h. The TLC to intermediate state reaction is complete. The reaction solution is cooled to room temperature, plus into 20L of ice water, stir for 20min. The aqueous phase was extracted twice with 10L of dichloromethane and the organic phases were combined. The organic phase is concentrated under reduced pressure to dry, a solid of 1232g was obtained, the yield was 88.6%, and the liquid phase was 98%.
Synthesis
5453-67-8
1195-59-1
General procedure for the synthesis of 2,6-pyridinedimethanol from dimethyl pyridine-2,6-dicarboxylate: dimethyl pyridine-2,6-dicarboxylate (9.75 g, 50 mmol) was dissolved in 40 mL of anhydrous ethanol and stirred under ice-bath conditions. Sodium borohydride (7.8 g, 4 eq.) was added in batches over 15 min and the reaction mixture was kept stirring at 0°C for 1 hr. The ice bath was then removed and the reaction mixture was allowed to continue stirring at room temperature for 2 hours. Next, the reaction mixture was placed on a steam bath and heated to reflux for 10 hours. Upon completion of the reaction, the solvent was removed by vacuum distillation. The residue was mixed with 40 mL of acetone and heated on a steam bath for 1 hour, after which the solvent was again removed by vacuum distillation. The resulting residue was mixed with 40 mL of aqueous potassium carbonate and heated on a steam bath for 1 hour, after which the solvent was removed by vacuum distillation. The final residue was dissolved in 100 mL of water and the aqueous solution was continuously extracted with chloroform for 10 h. The final 2,6-pyridinedimethanol was obtained as 6 g (87% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.70 (t, J=7.6 Hz, 1H), 7.20 (d, J=7.7 Hz, 2H), 4.78 (s, 4H).
References
[1] Organic Letters, 2010, vol. 12, # 11, p. 2532 - 2535
[2] Heterocycles, 2015, vol. 90, # 1, p. 625 - 630
[3] Tetrahedron Letters, 2013, vol. 54, # 43, p. 5771 - 5774
[4] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2009, vol. 72, # 1, p. 198 - 203
[5] Organic and Biomolecular Chemistry, 2017, vol. 15, # 46, p. 9923 - 9931
2,6-Pyridinedimethanol Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou ChonTech Biopharma Co.,Ltd | 0512-63101022 13912623614 | sales@chontech.com | Austria | 220 | 58 |
| Wuhan Ying Yuan Bei Biological Limited | 13349903920 | 1540154086@qq.com | China | 2994 | 58 |
| HONEST PHARM CO.,LTD. | 0531-59840128 19353175568 | zpy8217@163.com | China | 433 | 58 |
| Shanghai Runna Chemical Technology Co., Ltd | 13817852019 | runnahuagong@126.com | China | 49 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Lastest Price from 2,6-Pyridinedimethanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-01 | 2,6-Pyridinedimethanol
1195-59-1
|
1kg | 99% | 20tons | Shaanxi TNJONE Pharmaceutical Co., Ltd | ||
 |
2026-07-22 | 2,6-Pyridinedimethanol
1195-59-1
|
1kg | 99% | 20MT | Watson Biotechnology Co.,Ltd | ||
 |
2026-05-28 | 2,6-Pyridinedimethanol
1195-59-1
|
$9.00 | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 2,6-Pyridinedimethanol
1195-59-1
- $0.00
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- 2,6-Pyridinedimethanol
1195-59-1
- $0.00
- 99%
- Watson Biotechnology Co.,Ltd
-
- 2,6-Pyridinedimethanol
1195-59-1
- $9.00
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
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