2-Ethyl-3-methylpyrazine
- CAS No.
- 15707-23-0
- Chemical Name:
- 2-Ethyl-3-methylpyrazine
- Synonyms
- Pyrazine, 2-ethyl-3-methyl-;FEMA 3155;3-METHYL-2-ETHYLPYRAZINE;3-ETHYL-2-METHYLPYRAZINE;FEMA NUMBER 3155;filbert pyrazine;Ethyl-3-Methylpyraz;2-Ethyl-3-Methylpyra;2-METHYL-3-ETHYLPYRAZINE;2-ETHYL-3-METHYLPYRAZINE
- CBNumber:
- CB6170305
- Molecular Formula:
- C7H10N2
- Molecular Weight:
- 122.17
- MDL Number:
- MFCD00006150
- MOL File:
- 15707-23-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 57 °C10 mm Hg(lit.) |
|---|---|
| Density | 0.987 g/mL at 25 °C |
| vapor pressure | 1.74hPa at 20℃ |
| FEMA | 3155 | 2-ETHYL-3-METHYLPYRAZINE |
| refractive index |
n |
| FLAVIS Number | 14.006 | 2-Ethyl-3-methylpyrazine |
| Flash point | 138 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | sparingly soluble |
| pka | 1.94±0.10(Predicted) |
| Specific Gravity | 0.987 |
| color | Colorless to Light yellow |
| Odor | at 0.10 % in dipropylene glycol. nutty peanut musty corn raw earthy bread |
| Odor Type | nutty |
| biological source | synthetic |
| Water Solubility | sparingly soluble |
| JECFA Number | 768 |
| BRN | 956775 |
| Major Application | flavors and fragrances |
| Cosmetics Ingredients Functions | PERFUMING |
| InChI | 1S/C7H10N2/c1-3-7-6(2)8-4-5-9-7/h4-5H,3H2,1-2H3 |
| InChIKey | LNIMMWYNSBZESE-UHFFFAOYSA-N |
| SMILES | CCc1nccnc1C |
| LogP | 1.42 at 25℃ |
| CAS DataBase Reference | 15707-23-0(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | 3-ETHYL-2-METHYLPYRAZINE |
| EWG's Food Scores | 1 |
| FDA UNII | 9GF35MK66U |
| NIST Chemistry Reference | Pyrazine, 2-ethyl-3-methyl-(15707-23-0) |
| EPA Substance Registry System | Pyrazine, 2-ethyl-3-methyl- (15707-23-0) |
| UNSPSC Code | 12164502 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H302-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-24/25 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UQ3335000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2-Ethyl-3-methylpyrazine price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W315508 | 2-Ethyl-3-methylpyrazine ≥98%, FCC, FG | 15707-23-0 | 1 each | $58 | 2026-04-30 | Buy |
| Sigma-Aldrich | W315508 | 2-Ethyl-3-methylpyrazine ≥98%, FCC, FG | 15707-23-0 | 100g | $211 | 2026-04-30 | Buy |
| Sigma-Aldrich | W315508 | 2-Ethyl-3-methylpyrazine ≥98%, FCC, FG | 15707-23-0 | 1kg | $634 | 2026-04-30 | Buy |
| Sigma-Aldrich | W315508 | 2-Ethyl-3-methylpyrazine ≥98%, FCC, FG | 15707-23-0 | 5kg | $2460 | 2026-04-30 | Buy |
| Sigma-Aldrich | W315508 | 2-Ethyl-3-methylpyrazine ≥98%, FCC, FG | 15707-23-0 | 1 unit | $49.38 | 2025-07-31 | Buy |
2-Ethyl-3-methylpyrazine Chemical Properties, Uses, Production
Chemical Properties
clear colorless to slightly yellow liquid
Chemical Properties
2-Ethyl-3-methylpyrazine has a strong, raw-potato, roasted, earthy odor.
Occurrence
Reported found in bakery products, roasted barley, coffee, peanuts, filberts, potato products, soy products, roasted and fried chicken, beef, pork, beer, rum, cocoa, coffee, tea, malt, shrimp and crayfish.
Uses
2-Ethyl-3-methylpyrazine is used in preparation of Chinese chestnut pyrolyzate and their application to e-cigarette.
Uses
Food additive.
Definition
ChEBI: 2-Ethyl-3-methylpyrazine, 9CI is a member of pyrazines.
Preparation
By condensation of ethylenediamine with 2,3-pentanedione.
Aroma threshold values
Detection: 2 ppm (130 ppb in water)
Taste threshold values
Taste characteristics at 10 ppm: nutty, peanut, musty corn-like with raw and oily nuances.
Hazard
Moderately toxic by ingestion.
Flammability and Explosibility
Not classified
Safety Profile
Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes.
Synthesis
600-14-6
107-15-3
15707-23-0
2,3-Pentanedione, ethylenediamine and anhydrous ethanol were mixed in a three-necked flask at -5 to 3°C in a mass ratio of 1:1.1:70 and the reaction was stirred for 7 hours. After completion of the reaction, the system was slowly warmed to room temperature and stirring was continued for 3 hours. Subsequently, the temperature was raised to 65-70°C and refluxed for 4 hours. After the reaction mixture was cooled to 30-40 °C, xylene and potassium hydroxide catalyst was added to a three-necked flask, where the mass ratio of 2,3-pentanedione, potassium hydroxide to xylene was 1:0.8:2.8. Heating was continued to 65-70 °C and refluxed for 5 h. The reaction mixture was then cooled to room temperature and stirred for 7 h. The reaction mixture was then cooled to room temperature and stirred for 4 h. After the reaction was completed, it was cooled to room temperature and subjected to filtration. The filtrate was distilled at atmospheric pressure and the resulting concentrate was extracted with saturated brine solution, the organic phases were combined and dried with anhydrous sodium sulfate. The dried organic phase was filtered and subjected to atmospheric pressure distillation to collect the 55-60 °C/1.33 kPa fraction to give 2-ethyl-3-methylpyrazine in more than 93.5% product yield.
References
[1] Patent: CN107556250, 2018, A. Location in patent: Paragraph 0024; 0029; 0035; 0041; 0049; 0053
2-Ethyl-3-methylpyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| jiliang chemicals | 21-62165282 | bidingchem@163.com | China | 1395 | 60 |
View Latest Price from 2-Ethyl-3-methylpyrazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Ethyl-3-methylpyrazine
15707-23-0
|
$1.20-31.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 2-Ethyl-3-methylpyrazine
15707-23-0
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | 2-Ethyl-3-Methylpyrazine
15707-23-0
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 2-Ethyl-3-methylpyrazine
15707-23-0
- $1.20-31.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Ethyl-3-methylpyrazine
15707-23-0
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-Ethyl-3-Methylpyrazine
15707-23-0
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
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