ChemicalBook >> CAS DataBase List >>(S)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride
(S)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride
- CAS No.
- 39637-99-5
- Chemical Name:
- (S)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride
- Synonyms
- MOSHER'S ACID CHLORIDE;(-)-Mosher's Acid Chloride;(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride;(+)-MTPA-CL;(R)-(−(S)-(+)-MTPA-CL;(R)-MTPA chloride;(R)-(-)-Acid chloride;(+)-MOSHER'S CHLORIDE;(+)-MOSHER'S ACID CHLORIDE
- CBNumber:
- CB6170769
- Molecular Formula:
- C10H8ClF3O2
- Molecular Weight:
- 252.62
- MDL Number:
- MFCD00044400
- MOL File:
- 39637-99-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-09-12 18:53:59
| Boiling point | 213-214 °C(lit.) |
|---|---|
| alpha | D25 -10.0± 0.1° (neat, l = 1) |
| Density | 1.35 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 194 °F |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| form | Liquid |
| color | Clear colorless to light yellow |
| Specific Gravity | 1.353 |
| optical activity | [α]20/D 137±2°, c = 6.4% in carbon tetrachloride |
| Water Solubility | Sparingly miscible with water. |
| Sensitive | Moisture Sensitive |
| Merck | 14,6280 |
| BRN | 3591565 |
| InChI | 1S/C10H8ClF3O2/c1-16-9(8(11)15,10(12,13)14)7-5-3-2-4-6-7/h2-6H,1H3/t9-/m0/s1 |
| InChIKey | PAORVUMOXXAMPL-VIFPVBQESA-N |
| SMILES | CO[C@](C(Cl)=O)(c1ccccc1)C(F)(F)F |
| CAS DataBase Reference | 39637-99-5(CAS DataBase Reference) |
| FDA UNII | 81UT10UHV3 |
| UNSPSC Code | 12000000 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-27-36/37/39-45 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| Hazard Note | Corrosive/Freeze | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29189900 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
(S)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 65363 | (R)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride for chiral derivatization, ≥99.0% | 39637-99-5 | 100mg | $162 | 2026-04-30 | Buy |
| Sigma-Aldrich | 65363 | (R)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride for chiral derivatization, ≥99.0% | 39637-99-5 | 500mg | $640 | 2026-04-30 | Buy |
| TCI Chemical | M1104 | (R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines] >98.0%(GC) | 39637-99-5 | 100mg | $55 | 2026-04-30 | Buy |
| TCI Chemical | M1104 | (R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines] >98.0%(GC) | 39637-99-5 | 1g | $322 | 2026-04-30 | Buy |
| Biosynth | FT105924 | (R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride | 39637-99-5 | 2g | $900 | 2026-06-04 | Buy |
(S)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride Chemical Properties,Uses,Production
Chemical Properties
clear colorless to light yellow liquid
Uses
(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride is used as a chiral acylating reagent, which is used in the resolution of amino acid enantiomers like 2,5-dimethoxy-4-methylamphetamine. It is also suitable for the determination of the optical composition of compounds extracted from biological fluids.
Purification Methods
The most likely impurity is the free acid due to hydrolysis and should be checked by IR. If free from acid, then distil, taking care to keep moisture out of the apparatus. Otherwise add SOCl2 and reflux for 5hours and distil it. Note that shorter reflux times result in a higher boiling fraction (b 130-155o/1mm) which has been identified as the anhydride. [Dale et al. J Org Chem 34 2543 1969, for enantiomeric purity see Dale & Mosher J Am Chem Soc 97 512 1973.]
(S)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride Suppliers
Global( 127)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Tianjin Derchemist Science & Technology Co., Ltd. | 22-58627059 13920586291 | zdcomcon@126.com | China | 4094 | 50 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
View Lastest Price from (S)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
39637-99-5
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
39637-99-5
- $1.00
- 99%
- Career Henan Chemical Co
39637-99-5((S)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride)Related Search:
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1of4
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(R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%
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(-)-MTPA-Cl
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(1R)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride 99% (99%ee)
(R)-(-)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride, 97+%
(2R)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99% (99%ee)
(R)-(-)-MTPACl, (R)-(-)-Mosher's acid chloride, (2R)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropionyl chloride
(-)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetyl Chloride
[for DeterMination of the optical purity of Alcohols and AMines]
(R)-2-Methoxy-2-(trifluoromethyl)phenylacetyl chloride
(2R)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoylchloride99%
(R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride,99%
(2R)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99%
(R)-(-)-alphaMethoxy-alpha(three fluoroMethyl)phenyl acetyl chloride
(R)-MTPA chloride
(2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride
(R)-(-)-Acid chloride
(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride (ca. 18% in Dichloromethane, ca. 1.0mol/L) [for Determination of the optical purity of Alcohols and Amines]
(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride, 99%, 18wt.% solution in dichloromethane
(R)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL)-PH ENYLACETYL CHLORIDE, 98%(98% EE/GLC)
(R)-(-)-Mosher'sacidchloride
(R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetylchloride(ee)
(-)--Methoxy--(trifluoromethyl)phenylacetylchloride
(r)-(-)-à-methoxy-à-(trifluoromethyl)phenylacetyl chloride
(R)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride 99% (99%ee)
(r)-(-)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride (R)-(fi)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride (r)-(-)-a-methoxy-a-(trifluoromethyl) phenylacetyl chloride
(R)-(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 99%
(R)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride (99%ee)
(R)-(-)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetyl chloride, 98+%
(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(+)-MTPA-CL
(+)-MOSHER'S ACID CHLORIDE
MOSHER'S ACID CHLORIDE
(+)-MOSHER'S CHLORIDE
(S)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(S)-(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)BENZENEACETYLCHLORIDE
(S)-(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
(S)-(+)-MTPA-CL
(S)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYL ACETYL CHLORIDE
(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid chloride
(R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride (ca. 18% in Dichloromethane, ca. 1.0mol/L)[for Determination of the optical purity of Alcohols and Amines]
(R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
(-)-α-Methoxy-α-(trifluoromethyl)phenylacetylChloride[forDeterminationoftheopticalpurityofAlcoholsandAmines]>
(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride, 99%, n20D:1.4680 - 1.4700
Benzeneacetyl chloride, α-methoxy-α-(trifluoromethyl)-, (αR)-
(R)-(-)-a-Methoxy-a-trifluoromethylphenylacetyl chloride (ca. 18% in Dichloromethane, ca. 1.0mol/L)
(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride
(-)-Mosher's Acid Chloride
(R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl ch
