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GAMMA-METHYL-L-LEUCINE

GAMMA-METHYL-L-LEUCINE structure

CAS No.: 57224-50-7

Chemical Name:: GAMMA-METHYL-L-LEUCINE

Synonyms: (S)-2-AMINO-4,4-DIMETHYLPENTANOIC ACID;γ-methyl-l-leucine;gamma-methylleucine;H-LEU(ME)-OH;H-L-tBuAla-OH;H-L-NPTGLY-OH;H-ALA(TBU)-OH;β-tBu-L-Ala-OH;H-b-tBu-Ala-OH;BETA-TBU-ALANINE

CBNumber:: CB6176701

Molecular Formula:: C7H15NO2

Molecular Weight:: 145.2

MDL Number:: MFCD00066079

MOL File:: 57224-50-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:29:27

Product description	Number	Pack Size	Price
L-α-Neopentylglycine ≥98.0%(TLC)	73489	1g	$407
beta-tert-Butyl-L-alanine Asreported	265131	500mg	$333
beta-tert-Butyl-L-alanine Asreported	265131	1g	$460
beta-tert-Butyl-L-alanine Asreported	265131	2g	$616
beta-tert-Butyl-L-alanine Asreported	265131	5g	$984
More product size

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GAMMA-METHYL-L-LEUCINE Properties

Melting point	250 - 252°C
Boiling point	236.0±23.0℃ (760 Torr)
Density	1.016±0.06 g/cm3 (20 ºC 760 Torr)
Flash point	96.5±22.6℃
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Methanol (Slightly), Water (Sparingly)
form	Solid
pka	2.56±0.23(Predicted)
color	White to Off-White
optical activity	Consistent with structure
Major Application	peptide synthesis
InChI	InChI=1S/C7H15NO2/c1-7(2,3)4-5(8)6(9)10/h5H,4,8H2,1-3H3,(H,9,10)/t5-/m0/s1
InChIKey	LPBSHGLDBQBSPI-YFKPBYRVSA-N
SMILES	C(O)(=O)[C@@H](N)CC(C)(C)C
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501
PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
F	10
Storage Class	11 - Combustible Solids

GAMMA-METHYL-L-LEUCINE price More Price(60)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	73489	L-α-Neopentylglycine ≥98.0%(TLC)	57224-50-7	1g	$407	2026-04-30	Buy
Usbiological	265131	beta-tert-Butyl-L-alanine Asreported	57224-50-7	500mg	$333	2026-06-03	Buy
Usbiological	265131	beta-tert-Butyl-L-alanine Asreported	57224-50-7	1g	$460	2026-06-03	Buy
Usbiological	265131	beta-tert-Butyl-L-alanine Asreported	57224-50-7	2g	$616	2026-06-03	Buy
Usbiological	265131	beta-tert-Butyl-L-alanine Asreported	57224-50-7	5g	$984	2026-06-03	Buy

Product number	Packaging	Price	Buy
73489	1g	$407	Buy
265131	500mg	$333	Buy
265131	1g	$460	Buy
265131	2g	$616	Buy
265131	5g	$984	Buy

GAMMA-METHYL-L-LEUCINE Chemical Properties,Uses,Production

Chemical Properties

White to off-white powder

Uses

Gamma-methyl-L-leucine

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

34906-87-1

3060-50-2

119-61-9

57224-50-7

88319-43-1

GENERAL STEPS: To a 5 mL reaction vial equipped with a magnetic stirrer was added 3-cyclohexyl-2-oxopropanoic acid (1j) (0.0510 g, 0.30 mmol), 2,2-diphenylglycine (2) (0.0681 g, 0.30 mmol), chiral pyridoxamine 6 g (0.0195 g, 0.030 mmol) and MeOH-H2O (8:2) , v/v) (3.0 mL). The reaction mixture was stirred at 20 °C for 3 days. Upon completion of the reaction, the mixture was transferred to a 25 mL round-bottom flask and methanol was added until all solids were completely dissolved. Silica gel (0.50 g) was then added. The solvent was removed by reduced pressure distillation at 20 °C and the resulting residue was purified by silica gel column chromatography (eluent ratio EtOH/ethyl acetate/25-28% ammonia solution = 100:58:16) to afford compound 3j (0.0401 g, 78% yield, 52% ee) as a white solid. To determine the enantiomeric excess of 3b-k, compound 3j was first treated with thionyl chloride in methanol and subsequently converted to N-benzoylmethyl ester by reaction with benzoyl chloride and finally analyzed by HPLC. For the determination of enantiomeric excess of compound 3a, it was converted to methyl ester by treatment with CH2N2 in methanol followed by HPLC analysis.

References

[1] Tetrahedron Letters, 2016, vol. 57, # 41, p. 4612 - 4615

GAMMA-METHYL-L-LEUCINE Preparation Products And Raw materials

Raw materials

4,4-DIMETHYL-2-OXO-PENTANOIC ACID Pentanenitrile, 2-amino-4,4-dimethyl- 2,2-Diphenylglycine Water Methanol

Preparation Products

GAMMA-METHYL-L-LEUCINE Suppliers

Global( 115)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2993	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8491	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21189	58
GL Biochem (Shanghai) Ltd.	+86-021-61263370 +86-18901917034		CHINA	3904	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29096	58
Finetech Industry Limited	+86-27-8746-5837 +86-18627785180	info@finetechnology-ind.com	China	9539	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19904	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +86-15355479329	market18@leapchem.com	China	43303	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Zhejiang ZETian Fine Chemicals Co. LTD	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
GL Biochem (Shanghai) Ltd.	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58
Nextpeptide Inc	58
TargetMol Chemicals Inc.	58
HANGZHOU LEAP CHEM CO., LTD.	58

GAMMA-METHYL-L-LEUCINE Spectrum

GAMMA-METHYL-L-LEUCINE(57224-50-7)¹HNMR

57224-50-7(GAMMA-METHYL-L-LEUCINE)Related Search:

BETA-TBU-DL-ALANINE Ethyl sarcosinate hydrochloride H-SAR-OTBU HCL N-ME-GLY-OBZL P-TOSYLATE N-ALPHA-METHYL-L-ALANINE HYDROCHLORIDE

Sarcosine methyl ester hydrochloride H-SAR-OBZL HCL 4-HYDROXYISOLEUCINE GAMMA-METHYL-D-LEUCINE FMOC-T-BUTYL-L-ALANINE

Boc-N-methyl-L-leucine N-ALPHA-CARBOBENZOXY-GAMMA-METHYL-L-LEUCINE DICYCLOHEXYLAMMONIUM SALT GAMMA-METHYL-L-LEUCINE

1of3

H-L-tBuAla-OH H-L-NptGly-OH=4-Methyl-L-leucine L-Nepentylglycine L-Neopentylglycine, 4-Methyl-L-leucine, ss-t-Butyl-L-alanine, (S)-2-Amino-4,4-dimethyl-pentanoic acid H-b-tBu-Ala-OH γ-Methyl-L-leucine, (S)-2-Amino-4,4-dimethylpentanoic acid, L-γ-Methylleucine L-alpha-Neopentylglycine >=98.0% (TLC) (2S)-2-Amino-4,4-dimethyl-pentanoic acid β-tBu-L-Ala-OH β-tert-Butyl-L-alanine≥ 99% (HPLC, Chiral purity) L-ALPHA-NEOPENTYLGLYCINE L-GAMMA-METHYLLEUCINE L-NEOPENTYLGLYCINE GAMMA-METHYL-L-LEUCINE H-LEU(ME)-OH H-LEU(GAMMA-ME)-OH H-L-NPTGLY-OH H-NEOPENTYLGLY-OH H-ALA(TBU)-OH H-BETA-TBU-ALA-OH BETA-TBU-ALANINE BETA-T-BUTYL-L-ALANINE BETA-TERT-BUTYL-L-ALANINE (-)-2-AMINO-4,4-DIMETHYLPENTANOIC ACID 4-METHYL-LEUCINE 4-METHYL-L-LEUCINE β-tert-Butyl-L-alanine T-BUTYL-L-ALANINE NEOPENTYLGLYCINE 3-tert-butyl-L-alanine H-Neopentylgly-OH, H-g-Me-Leu-OH Pentanoic acid, 2-amino-4,4-dimethyl-, (2S)- (2S)-2-amino-4,4-dimethylpentanoicaci L-α-Neopentylglycine L-g-Methylleucine L-α-Neopentylglycine (S)-2-AMINO-4,4-DIMETHYLPENTANOIC ACID gamma-methylleucine γ-methyl-l-leucine 57224-50-7 Glycine Derivatives Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives