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3-Methyl-pyridine-4-carboxamide

3-Methyl-pyridine-4-carboxamide Structure
3-Methyl-pyridine-4-carboxamide structure
CAS No.
251101-36-7
Chemical Name:
3-Methyl-pyridine-4-carboxamide
Synonyms
3-Methylisonicotinamide;3-Methyl-pyridine-4-carboxamide;4-Pyridinecarboxamide, 3-methyl-;4-Pyridinecarboxamide,3-methyl-(9CI);2-carbaMoyl-3-Methylpyridine-4-carboxylic acid
CBNumber:
CB6185419
Molecular Formula:
C7H8N2O
Molecular Weight:
136.15
MDL Number:
MFCD03411690
MOL File:
251101-36-7.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:00
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3-Methyl-pyridine-4-carboxamide Properties

Boiling point 290.8±28.0 °C(Predicted)
Density 1.157±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 14.98±0.50(Predicted)
InChI InChI=1S/C7H8N2O/c1-5-4-9-3-2-6(5)7(8)10/h2-4H,1H3,(H2,8,10)
InChIKey QMDMUIQZTHZWGH-UHFFFAOYSA-N
SMILES C1=NC=CC(C(N)=O)=C1C

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933399990

3-Methyl-pyridine-4-carboxamide price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth BKA10136 3-Methylisonicotinamide 251101-36-7 2.5g $442.5 2026-06-04 Buy
Apolloscientific OR950771 3-Methylisonicotinamide 95% 251101-36-7 100mg $25 2026-06-04 Buy
Apolloscientific OR950771 3-Methylisonicotinamide 95% 251101-36-7 250mg $32 2026-06-04 Buy
Apolloscientific OR950771 3-Methylisonicotinamide 95% 251101-36-7 1g $81 2026-06-04 Buy
Activate Scientific AS47117 3-Methylisonicotinamide 97% 251101-36-7 1g $122 2026-06-04 Buy
Product number Packaging Price Buy
BKA10136 2.5g $442.5 Buy
OR950771 100mg $25 Buy
OR950771 250mg $32 Buy
OR950771 1g $81 Buy
AS47117 1g $122 Buy

3-Methyl-pyridine-4-carboxamide Chemical Properties, Uses, Production

Synthesis

3-METHYL-4-PYRIDINECARBOXYLIC ACID

4021-12-9

3-METHYL-PYRIDINE-4-CARBOXAMIDE

251101-36-7

General procedure for the synthesis of 3-methylpyridine-4-carboxamide from 3-methyl-4-pyridinecarboxylic acid: 3-methyl-4-pyridinecarboxylic acid (0.5 g, 3.6 mmol) was dissolved in thionyl chloride (3 mL) and heated to reflux for 3 hours. Upon completion of the reaction, the excess thionyl chloride was removed by evaporation under reduced pressure. The resulting chloride solid was added to ammonium hydroxide solution (30 mL, 25% aqueous solution) in batches under ice bath conditions. Subsequently, the reaction mixture was slowly warmed to room temperature and stirred for 10 minutes. The reaction mixture was concentrated under reduced pressure and the resulting residue was purified by silica gel fast column chromatography (eluent: methanol/dichloromethane, 40:1) to give a white solid product in 63% yield. The product was characterized by 1H NMR (400 MHz, CD3OD): δ 8.50-8.48 (m, 1H), 8.46-8.44 (m, 1H), 7.42 (d, J = 5.0 Hz, 1H), 2.45 (s, 3H).

References

[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 12, p. 3559 - 3572
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1682 - 1697
[3] Patent: US2014/18360, 2014, A1
[4] Chemistry - A European Journal, 2016, vol. 22, # 24, p. 8301 - 8308

3-Methyl-pyridine-4-carboxamide Preparation Products And Raw materials

Raw materials

3-Methyl-4-pyridinecarboxylic acid 4-Pyridinecarboxaldehyde,3-methyl-,oxime(9CI) Thionyl chloride Ammonium hydroxide

Preparation Products

4-Pyridinecarbonitrile,3-(bromomethyl)-(9CI)

3-Methyl-pyridine-4-carboxamide Suppliers

Global Suppliers ( 34)
Supplier Tel Email Country ProdList Advantage
Guangzhou Liwen Technology Co., Ltd. 18028686850 404259597@qq.com China 412 58
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
SynAsst Chemical. 021-60343070 China 12731 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-58851090 13913916777 sales01@aikonchem.com China 15947 58
Cool Pharm, Ltd 021-58581007 18019463053 sales@coolpharm.com China 9999 58
Henan Alpha Chemical Co., Ltd. 0371-55055611 18137792234 3957071458@qq.com China 9969 58
ANHUI WITOP BIOTECH CO., LTD +8618071025641 eric@witopchemical.com China 23504 58
Dayang Chem (Hangzhou) Co.,Ltd. +86-0571-88938639 17705817739 info@dycnchem.com China 52451 58
HUNAN CHEMFISH SCIENTIFIC CO.,LTD 85521272 18932438858 sales@chemfish.com China 7780 58
Supplier Advantage
Guangzhou Liwen Technology Co., Ltd. 58
Shandong Xiya Chemical Co., Ltd 57
SynAsst Chemical. 55
Amadis Chemical Company Limited 58
Aikon International Limited 58
Cool Pharm, Ltd 58
Henan Alpha Chemical Co., Ltd. 58
ANHUI WITOP BIOTECH CO., LTD 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
HUNAN CHEMFISH SCIENTIFIC CO.,LTD 58

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2-carbaMoyl-3-Methylpyridine-4-carboxylic acid 4-Pyridinecarboxamide,3-methyl-(9CI) 3-Methylisonicotinamide 4-Pyridinecarboxamide, 3-methyl- 3-Methyl-pyridine-4-carboxamide 251101-36-7 Pyridines PYRIDINE AMIDE