SB 222200
- CAS No.
- 174635-69-9
- Chemical Name:
- SB 222200
- Synonyms
- CS-1124;SB 222200;SB-222200; SB222200;SB-222200, 10 mM in DMSO;(S)-3-Methyl-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;(S)-3-METHYL-2-PHENYL-N-(1-PHENYLPROPYL)-4-QUINOLINECARBOXAMIDE;3-Methyl-2-phenyl-N-((1S)-1-phenylpropyl)quinoline-4-carboxamide;3-METHYL-2-PHENYL-N-[(1S)-1-PHENYLPROPYL]-4-QUINOLINECARBOXAMIDE;4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-;SB222200//3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxaMide
- CBNumber:
- CB6358752
- Molecular Formula:
- C26H24N2O
- Molecular Weight:
- 380.48
- MDL Number:
- MFCD00944072
- MOL File:
- 174635-69-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 154℃ |
|---|---|
| Boiling point | 553.5±50.0 °C(Predicted) |
| Density | 1.142 |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: ~28 mg/mL, soluble |
| form | solid |
| pka | 12.88±0.46(Predicted) |
| color | light yellow |
| InChI | 1S/C26H24N2O/c1-3-22(19-12-6-4-7-13-19)28-26(29)24-18(2)25(20-14-8-5-9-15-20)27-23-17-11-10-16-21(23)24/h4-17,22H,3H2,1-2H3,(H,28,29)/t22-/m0/s1 |
| InChIKey | MQNYRKWJSMQECI-QFIPXVFZSA-N |
| SMILES | CC[C@H](NC(=O)c1c(C)c(nc2ccccc12)-c3ccccc3)c4ccccc4 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
SB 222200 price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S5192 | SB 222200 ≥98% (HPLC), solid | 174635-69-9 | 10mg | $202 | 2026-04-30 | Buy |
| Sigma-Aldrich | S5192 | SB 222200 ≥98% (HPLC), solid | 174635-69-9 | 50mg | $931 | 2026-04-30 | Buy |
| TCI Chemical | B6551 | SB 222200 | 174635-69-9 | 10MG | $136 | 2026-04-30 | Buy |
| Cayman Chemical | 29422 | SB 222200 ≥95% | 174635-69-9 | 5mg | $129 | 2026-04-30 | Buy |
| Cayman Chemical | 29422 | SB 222200 ≥95% | 174635-69-9 | 10mg | $245 | 2026-04-30 | Buy |
SB 222200 Chemical Properties, Uses, Production
Uses
3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide is a chemical agent used in the preparation of acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor as antipsychotics (1,2).
Definition
ChEBI: 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide is a member of quinolines.
Biological Activity
Potent and selective non-peptide NK 3 receptor antagonist. K i values are 4.4, >100,000 and 250 nM for human NK 3 , NK 1 and NK 2 receptors respectively. Brain penetrant and active in vivo .
in vivo
SB-222200 (5 mg/kg; 30 min pretreatment) produces inhibition of behavioral responses induced by NK-3 receptor-selective agonist senktide (HY-P0187) in mice[1].
SB-2222006 exhibits moderate oral bioavailability (rat 46%) and Cmax (rat 427 ng/mL) following oral administration (rat 10 mg/kg)[1].
SB-2222006 exhibits terminal elimination half-life (rat 1.9 h) due to high plasma clearance (56 mL/min/kg) following intravenous administration (rat 2.5 mg/kg)[1].
| Animal Model: | Male BALB/c mice (19-21 g)[1] |
| Dosage: | 5 mg/kg |
| Administration: | Oral administration |
| Result: | Produced 57% inhibition of senktide-induced behavioral responses in mice. |
| Animal Model: | Male Sprague-Dawley rats (300-400 g)[1] |
| Dosage: | 2.5 mg/kg for i.v.; 10 mg/kg for p.o. (Pharmacokinetic Analysis) |
| Administration: | Intravenous injection and oral gavage |
| Result: | Oral bioavailability (46%), T1/2 (1.9 h), Cmax (427 ng/mL). |
IC 50
NK3
storage
Store at RT
SB 222200 Preparation Products And Raw materials
Raw materials
Preparation Products
SB 222200 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
