3-Methyl-4-pyridinecarboxylic acid
- CAS No.
- 4021-12-9
- Chemical Name:
- 3-Methyl-4-pyridinecarboxylic acid
- Synonyms
- 3-METHYLPYRIDINE-4-CARBOXYLIC ACID;3-Methyl-isonicotinicaci;ASINEX-REAG BAS 07668195;5-Methylisonicotinic Acid;3-METHYL-ISONICOTINIC ACID;3-methylpyridine-4-carboxylate;3-Methylpyridin-4-carboxylic acid;3-METHYL-4-PYRIDINYLCARBOXIC ACID;3-Methyl-4-pyridinecarboxylic acid;4-Pyridinecarboxylic acid, 3-methyl-
- CBNumber:
- CB5220296
- Molecular Formula:
- C7H7NO2
- Molecular Weight:
- 137.14
- MDL Number:
- MFCD00128870
- MOL File:
- 4021-12-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 235℃ |
|---|---|
| Boiling point | 389℃ |
| Density | 1.230 |
| Flash point | 189℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 0.82±0.25(Predicted) |
| Appearance | White to light yellow Solid |
| InChI | InChI=1S/C7H7NO2/c1-5-4-8-3-2-6(5)7(9)10/h2-4H,1H3,(H,9,10) |
| InChIKey | OSMAGAVKVRGYGR-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(C(O)=O)=C1C |
| CAS DataBase Reference | 4021-12-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
3-Methyl-4-pyridinecarboxylic acid price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 63805 | 3-METHYL-ISONICOTINIC ACID 95% | 4021-12-9 | 1G | $35 | 2026-04-30 | Buy |
| AstaTech | 63805 | 3-METHYL-ISONICOTINIC ACID 95% | 4021-12-9 | 5G | $145 | 2026-04-30 | Buy |
| AstaTech | 63805 | 3-METHYL-ISONICOTINIC ACID 95% | 4021-12-9 | 25G | $535 | 2026-04-30 | Buy |
| Apolloscientific | OR912065 | 3-Methyl-4-pyridinecarboxylic acid 97% | 4021-12-9 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR912065 | 3-Methyl-4-pyridinecarboxylic acid 97% | 4021-12-9 | 1g | $25 | 2026-06-04 | Buy |
3-Methyl-4-pyridinecarboxylic acid Chemical Properties, Uses, Production
Uses
3-Methyl-4-pyridinecarboxylic acid can be used in the preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors for prevention and/or treatment of neurodegenerative disease.
Uses
An Isonicotinic Acid (I821760) derivative. Used in the preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors for prevention and/or treatment of neurodegenerative disease.
Synthesis
583-58-4
4021-12-9
The general procedure for the synthesis of 3-methyl-4-pyridinecarboxylic acid from 3,4-dimethylpyridine was as follows: 3,4-dimethylpyridine (119.30 g, 0.28 mol) was dissolved in diphenyl ether (150 mL) and heated to 150-170 °C, followed by the slow addition of selenium dioxide (62 g, 0.56 mol). Selenium dioxide was added in batches over a period of 1 hour. The reaction mixture was heated to 180 °C and maintained at this temperature for 1 hour. Upon completion of the reaction, the mixture was filtered while hot and the collected precipitate was washed with boiling water (3 x 300 mL). The filtrates were combined and extracted with chloroform (3 x 300 mL). The aqueous phase was evaporated to dryness and the resulting crude product was recrystallized from ethanol (450 mL) to give pure 3-methyl-4-pyridinecarboxylic acid (18 g, 47% yield) with a melting point of 220-222°C (Literature value: J. Chem. Soc., Perkin Trans. 1, 1984, 1501-1505, melting point 232°C).1H NMR (300 MHz, DMSO-d6) δ 8.59 (s, 1H), 8.04 (s, 1H), 8.47 (d, J = 4.8 Hz, 1H), 7.69 (d, J = 4.8 Hz, 1H), 2.48 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1682 - 1697
[2] Patent: US2014/18360, 2014, A1. Location in patent: Paragraph 0152
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10118 - 10129
[4] Patent: US5952343, 1999, A
[5] Patent: US5461154, 1995, A
3-Methyl-4-pyridinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Changer Pharmaceutical Technology Co. Ltd. | 15921595598;15921595598 | qd.yu@pharmachanger.com | China | 469 | 58 |
| Guangzhou Liwen Technology Co., Ltd. | 18028686850 | 404259597@qq.com | China | 412 | 58 |
| Hunan AsidiChem Pharmaceutical Co., Ltd. | 18274983040 | 1203123146@qq.com | China | 52 | 58 |
| Suzhou bonei Biotechnology Co., Ltd | 13812661976 | info@szbiolight.com | China | 380 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from 3-Methyl-4-pyridinecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 3-Methylisonicotinic acid
4021-12-9
|
$3.90-5.90 | 1KG | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | ||
 |
2026-08-20 | 3-METHYL-4-PYRIDINECARBOXYLIC ACID
4021-12-9
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-08-12 | 3-METHYL-4-PYRIDINECARBOXYLIC ACID
4021-12-9
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd |
-
- 3-Methylisonicotinic acid
4021-12-9
- $3.90-5.90
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 3-METHYL-4-PYRIDINECARBOXYLIC ACID
4021-12-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3-METHYL-4-PYRIDINECARBOXYLIC ACID
4021-12-9
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
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