3-METHYL-4-PYRIDINECARBOXYLIC ACID
- CAS No.
- 4021-12-9
- Chemical Name:
- 3-METHYL-4-PYRIDINECARBOXYLIC ACID
- Synonyms
- ASINEX-REAG BAS 07668195;3-Methyl-isonicotinicaci;5-Methylisonicotinic Acid;3-METHYL-ISONICOTINIC ACID;3-methylpyridine-4-carboxylate;3-METHYL-4-PYRIDINYLCARBOXIC ACID;3-Methylpyridin-4-carboxylic acid;3-METHYLPYRIDINE-4-CARBOXYLIC ACID;3-METHYL-4-PYRIDINECARBOXYLIC ACID;4-Pyridinecarboxylic acid, 3-methyl-
- CBNumber:
- CB5220296
- Molecular Formula:
- C7H7NO2
- Molecular Weight:
- 137.14
- MDL Number:
- MFCD00128870
- MOL File:
- 4021-12-9.mol
| Product description | Number | Pack Size | Price |
| 3-MethylIsonicotinicAcid | M323315 | 5g | $1260 |
| 3-Methyl-4-pyridinecarboxylicacid | B205 | 100g | $1667 |
| 3-METHYL-ISONICOTINIC ACID 95.00% | CHM0023855 | 25G | $1008 |
| 3-Methyl-4-pyridinecarboxylicacid 95% | OR912065 | 1g | $110 |
| 3-Methyl-isonicotinic acid | 020640 | 500mg | $129 |
| More product size | |||
| Melting point | 235℃ |
|---|---|
| Boiling point | 389℃ |
| Density | 1.230 |
| Flash point | 189℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 0.82±0.25(Predicted) |
| Appearance | White to light yellow Solid |
| InChI | InChI=1S/C7H7NO2/c1-5-4-8-3-2-6(5)7(9)10/h2-4H,1H3,(H,9,10) |
| InChIKey | OSMAGAVKVRGYGR-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(C(O)=O)=C1C |
| CAS DataBase Reference | 4021-12-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
3-METHYL-4-PYRIDINECARBOXYLIC ACID price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M323315 | 3-MethylIsonicotinicAcid | 4021-12-9 | 5g | $1260 | 2021-12-16 | Buy |
| AK Scientific | B205 | 3-Methyl-4-pyridinecarboxylicacid | 4021-12-9 | 100g | $1667 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0023855 | 3-METHYL-ISONICOTINIC ACID 95.00% | 4021-12-9 | 25G | $1008 | 2021-12-16 | Buy |
| Apolloscientific | OR912065 | 3-Methyl-4-pyridinecarboxylicacid 95% | 4021-12-9 | 1g | $110 | 2021-12-16 | Buy |
| Matrix Scientific | 020640 | 3-Methyl-isonicotinic acid | 4021-12-9 | 500mg | $129 | 2021-12-16 | Buy |
3-METHYL-4-PYRIDINECARBOXYLIC ACID Chemical Properties,Uses,Production
Uses
3-Methyl-4-pyridinecarboxylic acid can be used in the preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors for prevention and/or treatment of neurodegenerative disease.
Uses
An Isonicotinic Acid (I821760) derivative. Used in the preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors for prevention and/or treatment of neurodegenerative disease.
Synthesis
583-58-4
4021-12-9
The general procedure for the synthesis of 3-methyl-4-pyridinecarboxylic acid from 3,4-dimethylpyridine was as follows: 3,4-dimethylpyridine (119.30 g, 0.28 mol) was dissolved in diphenyl ether (150 mL) and heated to 150-170 °C, followed by the slow addition of selenium dioxide (62 g, 0.56 mol). Selenium dioxide was added in batches over a period of 1 hour. The reaction mixture was heated to 180 °C and maintained at this temperature for 1 hour. Upon completion of the reaction, the mixture was filtered while hot and the collected precipitate was washed with boiling water (3 x 300 mL). The filtrates were combined and extracted with chloroform (3 x 300 mL). The aqueous phase was evaporated to dryness and the resulting crude product was recrystallized from ethanol (450 mL) to give pure 3-methyl-4-pyridinecarboxylic acid (18 g, 47% yield) with a melting point of 220-222°C (Literature value: J. Chem. Soc., Perkin Trans. 1, 1984, 1501-1505, melting point 232°C).1H NMR (300 MHz, DMSO-d6) δ 8.59 (s, 1H), 8.04 (s, 1H), 8.47 (d, J = 4.8 Hz, 1H), 7.69 (d, J = 4.8 Hz, 1H), 2.48 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1682 - 1697
[2] Patent: US2014/18360, 2014, A1. Location in patent: Paragraph 0152
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10118 - 10129
[4] Patent: US5952343, 1999, A
[5] Patent: US5461154, 1995, A
3-METHYL-4-PYRIDINECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
View Lastest Price from 3-METHYL-4-PYRIDINECARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-11-18 | 3-METHYL-4-PYRIDINECARBOXYLIC ACID
4021-12-9
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-10-13 | 3-Methylisonicotinic acid
4021-12-9
|
US $3.90-5.90 / KG | 1KG | 99% | g-kg-tons, free sample is available | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
-
- 3-METHYL-4-PYRIDINECARBOXYLIC ACID
4021-12-9
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 3-Methylisonicotinic acid
4021-12-9
- US $3.90-5.90 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
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