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STATIL

STATIL Structure
STATIL structure
CAS No.
72702-95-5
Chemical Name:
STATIL
Synonyms
STATIL;MK-538;ICI-plc;ICI-128436;Ponalrestat;Ponalrestat (MK-538;Ponalrestat - Bio-X ?;Ponalrestat, 10 mM in DMSO;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID;Ponalrestat Statil
CBNumber:
CB6193847
Molecular Formula:
C17H12BrFN2O3
Molecular Weight:
391.19
MDL Number:
MFCD00204117
MOL File:
72702-95-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
Ponalrestat ≥98% (HPLC) SML3079 5 mg $104
Ponalrestat ≥98% (HPLC) SML3079 25 mg $420
Statil ≥98% 19189 5mg $36
Statil ≥98% 19189 10mg $63
Statil ≥98% 19189 25mg $128
More product size
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STATIL Properties

Melting point 184-186℃ (DEC.)
Density 1.60
storage temp. Store at RT
solubility DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL
form A crystalline solid
color White to off-white
InChI InChI=1S/C17H12BrFN2O3/c18-11-6-5-10(14(19)7-11)9-21-17(24)13-4-2-1-3-12(13)15(20-21)8-16(22)23/h1-7H,8-9H2,(H,22,23)
InChIKey LKBFFDOJUKLQNY-UHFFFAOYSA-N
SMILES C12C=CC=CC=1C(=O)N(CC1=CC=C(Br)C=C1F)N=C2CC(=O)O
FDA UNII 2CV0A5G64E
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Risk Statements  36/37/38
Safety Statements  26-36/37/39
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

STATIL price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3079 Ponalrestat ≥98% (HPLC) 72702-95-5 5 mg $104 2026-04-30 Buy
Sigma-Aldrich SML3079 Ponalrestat ≥98% (HPLC) 72702-95-5 25 mg $420 2026-04-30 Buy
Cayman Chemical 19189 Statil ≥98% 72702-95-5 5mg $36 2026-04-30 Buy
Cayman Chemical 19189 Statil ≥98% 72702-95-5 10mg $63 2026-04-30 Buy
Cayman Chemical 19189 Statil ≥98% 72702-95-5 25mg $128 2026-04-30 Buy
Product number Packaging Price Buy
SML3079 5 mg $104 Buy
SML3079 25 mg $420 Buy
19189 5mg $36 Buy
19189 10mg $63 Buy
19189 25mg $128 Buy

STATIL Chemical Properties,Uses,Production

Description

Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.

Uses

Inhibitor (aldose reductase).

Uses

Statil is a knon aldose reductase inhibitor which blocks the conversion of glucose to sorbitol. In addition it suppresses cell cancer growth

Definition

ChEBI: 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxo-1-phthalazinyl]acetic acid is a member of phthalazines.

Biological Activity

Potent aldose reductase inhibitor.

in vivo

Ponalrestat (ICI 128436; 10, 50 mg/kg; orally; daily; 8 weeks) reduces sorbitol accumulation indicating efficacy of aldose reductase inhibition[3].

Animal Model:Adult female Sprague-Dawley rats[3]
Dosage:10, 50 mg/kg
Administration:Orally; daily; 8 weeks
Result:Reduced sorbitol accumulation.

References

[1] WALTER H.J. WARD . Ponalrestat: A potent and specific inhibitor of aldose reductase[J]. Biochemical pharmacology, 1990, 39 2: Pages 337-346. DOI: 10.1016/0006-2952(90)90033-h
[2] DONNA J. OTTER  Russell C W. The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats[J]. British Journal of Pharmacology, 1994, 113 2: 576-580. DOI: 10.1111/j.1476-5381.1994.tb17028.x
[3] ANDRéANNE MICHAUD. Prostaglandin (PG) F2 alpha synthesis in human subcutaneous and omental adipose tissue: modulation by inflammatory cytokines and role of the human aldose reductase AKR1B1.[J]. PLoS ONE, 2014: e90861. DOI: 10.1371/journal.pone.0090861

STATIL synthesis

76283-09-5
25947-13-1
72702-95-5
Synthesis of STATIL from 4-Bromo-2-fluorobenzyl bromide and (4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID ETHYL ESTER

STATIL Preparation Products And Raw materials

Raw materials

4-Bromo-2-fluorobenzyl bromide (4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID ETHYL ESTER

Preparation Products

STATIL Suppliers

Global( 104)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32998 60
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Henan Alfa Chemical Co., Ltd 		+8618339805032 sale03@alfachem.cn China 9817 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49709 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11674 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501 product@acmec-e.com China 33301 58
Aladdin Scientific 		tp@aladdinsci.com United States 50110 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Henan Alfa Chemical Co., Ltd 		58
InvivoChem 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58

View Lastest Price from STATIL manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ponalrestat pictures 2026-07-27 Ponalrestat
72702-95-5
 $39.00-64.00 98.05% 10g TargetMol Chemicals Inc.
STATIL;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID; pictures 2019-12-25 STATIL;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID;
72702-95-5
 $1.00 1KG 99% 200kg Career Henan Chemical Co
  • Ponalrestat pictures
  • Ponalrestat
    72702-95-5
  • $39.00-64.00
  • 98.05%
  • TargetMol Chemicals Inc.

STATIL Spectrum

STATIL(72702-95-5)1HNMR

72702-95-5(STATIL)Related Search:

STATIL BENZYL-(2-FLUORO-BENZYL)-AMINE 4-BROMO-2-FLUOROBENZYLAMINE 1,1-Dibenzylhydrazine (4-BROMOBENZYL)METHYLAMINE
(2-FLUORO-BENZYL)-HYDRAZINE (3-METHYL-4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID (4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETIC ACID 3-(2-FORMYLPHENYL)PROPANOIC ACID CHEMBRDG-BB 5937785
4-BROMO-BENZYL-HYDRAZINE 4-Bromo-2-fluorotoluene 4-ETHYL-2H-PHTHALAZIN-1-ONE

1of3

STATIL [3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID Ponalrestat 3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL) 3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid ICI-128436 ICI-plc MK-538 2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid Ponalrestat Statil Ponalrestat (MK-538 ICI128436,ICI 128436,glucose,ALR,AKR1B1,Ponalrestat,Inhibitor,Aldose Reductase,conversion,inhibit,sorbitol,ICI-128436,orally,noncompetitive,ALR2,ALR1 Ponalrestat, 10 mM in DMSO Ponalrestat - Bio-X ? 72702-95-5 C17H12BrFN2O3 Inhibitors