Methoxypolyethylene glycols
- CAS No.
- 9004-74-4
- Chemical Name:
- Methoxypolyethylene glycols
- Synonyms
- MPEG;MPEG-OH;POLYETHYLENE GLYCOL MONOMETHYL ETHER;METHOXYPOLYETHYLENE GLYCOL;POLYETHYLENE GLYCOL MONOMETHYL ETHER 550;MEO-PEG-OH;PEG-6 METHYL ETHER;MPEG 500;MPEG 550;MEO-PEG-COOH
- CBNumber:
- CB6228002
- Molecular Formula:
- (C2H4O)nCH4O
- Molecular Weight:
- 120.14698
- MDL Number:
- MFCD00084416
- MOL File:
- 9004-74-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 60-64 °C |
|---|---|
| Boiling point | >200°C/760mmHg |
| Density | 1.094 g/mL at 25 °C |
| vapor density | >1 (vs air) |
| vapor pressure | 0.05 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 268 °C |
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL at 25 °C, clear, colorless |
| form | semisolid |
| pka | 4.5-4.8 |
| color | White to pale yellow |
| Specific Gravity | 1.094 |
| PH | 5.5-7.0 (25℃, 50mg/mL in H2O) |
| Odor | Mild odor |
| Viscosity | 10.5cs (99C) |
| Viscosity | 4.1cs (99C) |
| Viscosity | 63cs (99C) |
| Viscosity | 7.5cs (99C) |
| Water Solubility | Slightly miscible with water. |
| λmax |
λ: 260 nm Amax: 0.06 λ: 280 nm Amax: 0.03 |
| α-end | methoxy |
| Ω-end | hydroxyl |
| Stability | Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. |
| Cosmetics Ingredients Functions |
HUMECTANT SOLVENT |
| Cosmetic Ingredient Review (CIR) | Methoxypolyethylene glycols (9004-74-4) |
| InChI | 1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3 |
| InChIKey | XNWFRZJHXBZDAG-UHFFFAOYSA-N |
| SMILES | O(CCO)C |
| LogP | -0.800 (est) |
| EWG's Food Scores | 1-3 |
| FDA UNII |
METHOXY PEG-40 (6AXS45P1QU) PEG-4 METHYL ETHER (3S6PWQ487V) METHOXY PEG-20 (77U9H6E11K) METHOXY PEG-16 (89ES36762B) PEG-7 METHYL ETHER (ENK4Y6S66X) |
| EPA Substance Registry System | Poly(oxy-1,2-ethanediyl), .alpha.-methyl-.omega.-hydroxy- (9004-74-4) |
| UNSPSC Code | 12162002 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H372-H302-H319-H336-H335 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P260-P264-P270-P314-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P403+P233-P405-P501 | |||||||||
| Safety Statements | 24/25-22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | PE8271000 | |||||||||
| F | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29091990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Methoxypolyethylene glycols price More Price(166)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 71578 | Poly(ethylene glycol) methyl ether BioUltra, 500 | 9004-74-4 | 250g | $173 | 2026-04-30 | Buy |
| Sigma-Aldrich | 71578 | Poly(ethylene glycol) methyl ether BioUltra, 500 | 9004-74-4 | 1kg | $265 | 2026-04-30 | Buy |
| Sigma-Aldrich | 202487 | Poly(ethylene glycol) methyl ether average Mn 550 | 9004-74-4 | 5g | $58.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 202487 | Poly(ethylene glycol) methyl ether average Mn 550 | 9004-74-4 | 250g | $131 | 2026-04-30 | Buy |
| TCI Chemical | P2183 | Polyethylene Glycol Monomethyl Ether 400 | 9004-74-4 | 100g | $26 | 2026-04-30 | Buy |
Methoxypolyethylene glycols Chemical Properties, Uses, Production
Description
m-PEG36-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.
Chemical Properties
varies from viscous liquid to white flakes, depending
Uses
enteric coating controlled release and enteric release coatings
Uses
Methoxypolyethylene Glycol of with an average molecular mass of 350. Methoxypolyethylene Glycol (MPEG) is used in various applications such as micelles for drug delivery as well as in modifications of therapeutic proteins to improve their pharmacokinetics.
Uses
Methoxypolyethylene glycol 350 has been used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes. It has also been used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
Definition
ChEBI: A poly(ethylene glycol) terminated with a methyl group at one end.
brand name
Carbowax Sentry Methoxypolyethylene Glycol (Union Carbide).
General Description
It is a Polyethylene glycol (PEG) macromer with a reactive chain end consisting of methyl ether. Etherification of the PEG chain ends can be undertaken in basic conditions by reacting it with alkyl halides. mPEG can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.
Synthesis
To a stirred solution of 39.8 g of water-free methoxypoly(ethylene glycol) (0.1 mol) in 70 mL of CH₂Cl₂ was added 30.3 g of freshly distilled triethylamine (0.3 mol). The solution was flushed with N₂ and cooled to 10 °C. A total of 27.5 g of distilled acryloyl chloride (0.3 mol) in 30 mL of CH₂Cl₂ was added in the above mixture over a duration of 30 min under continuous stirring. The mixture was kept under stirring in a N₂ atmosphere for a period of 12 h at 10 °C. Triethylammonium chloride was filtered off. A minimum amount of benzene was added to the syrupy liquid to separate the residual triethylammonium chloride. The solvent was removed by distillation under reduced pressure; the liquid again was dissolved in CH₂Cl₂ and washed well with dilute saline water. The combined organic layer is then filtered through a "Fuller's earth" bed, and the solvent was removed from the filtrate under vacuum. The obtained Methoxypolyethylene glycols macromonomer was dried over molecular sieves overnight[1].
Solubility in organics
Acetone, chloroform, cyclohexanone, dichloromethane, DMF, MEK, toluene (hot), water
Toxics Screening Level
The initial threshold screening level (ITSL) for polyethylene glycol methyl ether , also known as dowanol TMH, is 13 μg/m3 based on an annual averaging time.
References
[1] Geetha, B., Mandal, A. B., & Ramasami, T. (1993). Synthesis, characterization, and micelle formation in an aqueous solution of methoxypolyethylene glycol macromonomer, homopolymer, and graft copolymer. Macromolecules, 26(16), 4083–4088. https://doi.org/10.1021/ma00068a002
Methoxypolyethylene glycols Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Ruiyao Mingzhi Medical Technology Co., Ltd | 15662630077 | 958367155@qq.com | China | 571 | 58 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| NBC (Shanghai) Chemical Co.,Ltd | 13671558889 | inquiry@pegderivatives.com | China | 184 | 58 |
| Liaoning kelong Fine Chemical Co.,Ltd | 18524016006 | carrie@kelongchem.com | China | 21 | 58 |
| Nantong Haitian Chemical Co., Ltd | 18795798512 13912858455 | 380119725@qq.com | China | 465 | 58 |
| Nantong Ruhr Chemical Co., Ltd. | 18012215199 | 3180741500@qq.com | China | 464 | 58 |
| Shanghai Toyang Biotechnology Co., LTD | 021-59555769 13524932310 | 1405894150@qq.com | China | 1082 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
Related articles
- What is Methoxypolyethylene glycols?
- Methoxypolyethylene glycols (mPEG) are addition polymers of ethylene oxide and methanol with the molecular formula CH3O-(CH2-C....
- Mar 15,2024
View Latest Price from Methoxypolyethylene glycols manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-20 | Methoxypolyethylene glycols
9004-74-4
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-02 | Methoxypolyethylene glycols
9004-74-4
|
$5.00-8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | Methoxypolyethylene glycols
9004-74-4
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- Methoxypolyethylene glycols
9004-74-4
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Methoxypolyethylene glycols
9004-74-4
- $5.00-8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Methoxypolyethylene glycols
9004-74-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
