1-METHYL-2-FORMYLBENZIMIDAZOLE
- CAS No.
- 3012-80-4
- Chemical Name:
- 1-METHYL-2-FORMYLBENZIMIDAZOLE
- Synonyms
- AKOS;1-methyl-1H-benzo[d]imidazole-2-carbaldehyde;AKOS BC-1517;ZERENEX EZX001709;TIMTEC-BB SBB010051;1-METHYL-2-FORMYLBENZIMIDAZOLE;1-Methyl-2-formylbenzimidazole 97%;2-Formyl-1-methyl-1H-benzimidazole;1-methyl-2-formyl-1H-benzimidazole;1-Methyl-2-formylbenzimidazole, 99+%
- CBNumber:
- CB6240789
- Molecular Formula:
- C9H8N2O
- Molecular Weight:
- 160.17
- MDL Number:
- MFCD00142655
- MOL File:
- 3012-80-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde min. 98.0 % | M3687 | 200MG | $46 |
| 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde min. 98.0 % | M3687 | 1G | $157 |
| 1-Methyl-2-formylbenzimidazole Asreported | 284526 | 1g | $385 |
| 1-Methyl-2-formylbenzimidazole Asreported | 284526 | 2g | $588 |
| 1-Methyl-2-formylbenzimidazole Asreported | 284526 | 5g | $827 |
| More product size | |||
| Melting point | 114-116 °C |
|---|---|
| Boiling point | 286.07°C (rough estimate) |
| Density | 1.1846 (rough estimate) |
| refractive index | 1.5570 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 3+-.0.10(Predicted) |
| form | Crystalline Powder |
| color | Off-white to light beige |
| Sensitive | Air Sensitive |
| CAS DataBase Reference | 3012-80-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
1-METHYL-2-FORMYLBENZIMIDAZOLE price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3687 | 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde min. 98.0 % | 3012-80-4 | 200MG | $46 | 2026-04-30 | Buy |
| TCI Chemical | M3687 | 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde min. 98.0 % | 3012-80-4 | 1G | $157 | 2026-04-30 | Buy |
| Usbiological | 284526 | 1-Methyl-2-formylbenzimidazole Asreported | 3012-80-4 | 1g | $385 | 2026-06-03 | Buy |
| Usbiological | 284526 | 1-Methyl-2-formylbenzimidazole Asreported | 3012-80-4 | 2g | $588 | 2026-06-03 | Buy |
| Usbiological | 284526 | 1-Methyl-2-formylbenzimidazole Asreported | 3012-80-4 | 5g | $827 | 2026-06-03 | Buy |
1-METHYL-2-FORMYLBENZIMIDAZOLE Chemical Properties,Uses,Production
Chemical Properties
OFF-WHITE TO LIGHT BEIGE CRYSTALLINE POWDER
Uses
1-Methyl-1H-benzimidazole-2-carboxaldehyde is a reagent used for the synthesis of dual protein kinase B alpha (AKT) and nuclear factor kappa-light-chain-enchancer of activated B cells (NF-κB) against melanoma.
Synthesis
1632-83-3
20461-86-3
3012-80-4
General procedure for the synthesis of 1-methyl-2-formylbenzimidazole from N-methylbenzimidazole and 2,2-diethoxyacetic acid: N-methylbenzimidazole (0.10 mmol, 1.0 eq.), ammonium persulfate (0.30 mmol, 3.0 eq.), and Cs2CO3 (0.20 mmol, 2.0 eq.) were placed in a dry glass tube. Subsequently, anhydrous DMSO (1 mL) and 2,2-diethoxyacetic acid (0.7 mmol) were added to the tube via syringe under nitrogen protection. The reaction mixture was stirred for 24 h at room temperature using 15 W blue LED strip irradiation. After completion of the reaction, the reaction was quenched by the addition of 1.2 mL of 3.0 M HCl and stirring was continued for 20 hours. Afterwards, the pH was adjusted with saturated Na2CO3 solution and extracted with CH2Cl2. The organic layers were combined, washed with brine and dried over anhydrous Na2SO4. Finally, the target product 1-methyl-2-formylbenzimidazole was purified by rapid chromatography on silica gel, using petroleum ether and ethyl acetate as eluents, and the corresponding yield was calculated.
References
[1] Synlett, 2018, vol. 29, # 14, p. 1881 - 1886
1-METHYL-2-FORMYLBENZIMIDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Nanjing jinheyou Trading Co., Ltd. | 15705188088 | admin@jheyou.com | CHINA | 1268 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49890 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618662433356 | 3899766280@qq.com | China | 26362 | 58 |
View Lastest Price from 1-METHYL-2-FORMYLBENZIMIDAZOLE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 1-METHYL-2-FORMYLBENZIMIDAZOLE
3012-80-4
|
$5.50 | 1KG | 98%min | 1kg-100kg | Career Henan Chemical Co | |
 |
2019-12-23 | 1-METHYL-2-FORMYLBENZIMIDAZOLE
3012-80-4
|
1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. |
-
- 1-METHYL-2-FORMYLBENZIMIDAZOLE
3012-80-4
- $5.50
- 98%min
- Career Henan Chemical Co
-
- 1-METHYL-2-FORMYLBENZIMIDAZOLE
3012-80-4
- $0.00
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
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