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Mefloquine hydrochloride

Mefloquine hydrochloride Structure
Mefloquine hydrochloride structure
CAS No.
51773-92-3
Chemical Name:
Mefloquine hydrochloride
Synonyms
MEFLOQUINE HCL;Loriam;wr14249;wr142490;Ro 21-5998/001;Mefloquine HCI;s*)-(r(+-)-lorid;Mefloquin hydrochloride;efloquine hydrochloride;MEFLOQUINE HYDROCHLORIDE
CBNumber:
CB6252498
Molecular Formula:
C17H17ClF6N2O
Molecular Weight:
414.77
MDL Number:
MFCD00797519
MOL File:
51773-92-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
Mefloquine hydrochloride ≥98% (HPLC), powder M2319 100mg $191
Mefloquine hydrochloride European Pharmacopoeia (EP) Reference Standard M0253000 100 mg $175
Mefloquine hydrochloride United States Pharmacopeia (USP) Reference Standard 1379059 100mg $394
Mefloquine Hydrochloride >98.0%(HPLC) M2313 1g $79
Mefloquine (hydrochloride) ≥98% 23665 50mg $54
More product size
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Mefloquine hydrochloride Properties

Melting point 250-254C
storage temp. 2-8°C
solubility DMSO: 38 mg/mL, soluble
form solid
color white
λmax 222nm(Acidic H2O)(lit.)
Merck 14,5801
BCS Class 4/2
Stability Temperature Sensitive
InChI InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/s3
InChIKey WESWYMRNZNDGBX-YLCXCWDSSA-N
SMILES C12N=C(C=C([C@@H](O)[C@@]3([H])NCCCC3)C=1C=CC=C2C(F)(F)F)C(F)(F)F.Cl |&1:5,7,r|
CAS DataBase Reference 51773-92-3(CAS DataBase Reference)
FDA UNII 5Y9L3636O3
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  22
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  VC0308000
HS Code  2933399090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
NFPA 704
0
1 0

Mefloquine hydrochloride price More Price(118)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M2319 Mefloquine hydrochloride ≥98% (HPLC), powder 51773-92-3 100mg $191 2026-04-30 Buy
Sigma-Aldrich M0253000 Mefloquine hydrochloride European Pharmacopoeia (EP) Reference Standard 51773-92-3 100 mg $175 2026-04-30 Buy
Sigma-Aldrich 1379059 Mefloquine hydrochloride United States Pharmacopeia (USP) Reference Standard 51773-92-3 100mg $394 2026-04-30 Buy
TCI Chemical M2313 Mefloquine Hydrochloride >98.0%(HPLC) 51773-92-3 1g $79 2026-04-30 Buy
Cayman Chemical 23665 Mefloquine (hydrochloride) ≥98% 51773-92-3 50mg $54 2026-04-30 Buy
Product number Packaging Price Buy
M2319 100mg $191 Buy
M0253000 100 mg $175 Buy
1379059 100mg $394 Buy
M2313 1g $79 Buy
23665 50mg $54 Buy

Mefloquine hydrochloride Chemical Properties,Uses,Production

Description

Mefloquine hydrochloride is an erythrocytic schizonticide useful, in combination with sulfadoxine and pyrimethamine, in the prophylaxis and treatment of malaria. Administered once weekly, the combination is effective against pathogens resistant to other agents.

Description

Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties. It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites. It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis. Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior. Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.

Chemical Properties

White Solid

Originator

Walter Reed (USA)

Uses

Mefloquine Hydrochloride (Polymorph Form E) is a polymorphic form of Mefloquine Hydrochloride (M207055), a quinoline methanol antimalarial agent.

Uses

Antimalarial;Heme polymerase inhibitor

Definition

ChEBI: Mefloquine hydrochloride is a hydrochloride.

brand name

FANSIMEF

General Description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards

Biochem/physiol Actions

Blocker of gap junction channels Cx36 and Cx50.

Clinical Use

The newest of the 4-aminoquinolines,mefloquine, is marketed as the R,S-isomer. It was developedin the 1960s as part of the U.S. Army’s WalterReed Institute for Medical Research antimalarial researchprogram. It differs significantly from the other agents in this class by having two trifluromethyl moieties at positions2’ and 8' and no electronegative substituents at eitherpositions 6' (quinine) or 7' (chloroquine). Mefloquine alsodiffers from chloroquine and its analogs by being a schizonticide acting before the parasite canenter the erythrocyte. There is some evidence that it acts byraising the pH in the parasite’s vesicles interfering with itsability to process heme. Mefloquine-resistant strains ofP. falciparum have appeared. Relapse can occur with acuteP. vivax that has been treated with mefloquine because thedrug does not eliminate the hepatic phase of this species,which can reinfect the liver.
Mefloquine is teratogenic in rats, mice, and rabbits. Thereis an FDA-required warning that this drug can cause exacerbatemental disorders and is contraindicated in patients withactive depression, a recent history of depression, generalizedanxiety disorder, psychosis, schizophrenia, and other majorpsychiatric disorders or a history of convulsions.

storage

Store at +4°C

References

[1] R. E. LUTZ  A. R P  C J Ohnmacht. Antimalarials. 7. Bis(trifluoromethyl)-.alpha.-(2-piperidyl)-4-quinolinemethanols[J]. Journal of Medicinal Chemistry, 1971, 14 10: 926-928. DOI: 10.1021/jm00292a008
[2] JILL M. COMBRINCK. Insights into the Role of Heme in the Mechanism of Action of Antimalarials[J]. ACS Chemical Biology, 2012, 8 1: 133-137. DOI: 10.1021/cb300454t
[3] BRYAN GRABIAS  Sanjai K. Adverse neuropsychiatric effects of antimalarial drugs.[J]. Expert Opinion on Drug Safety, 2016, 15 7: 903-910. DOI: 10.1080/14740338.2016.1175428
[4] J. HOLDEN. Behavioral effects of mefloquine in tail suspension and light/dark tests[J]. SpringerPlus, 2015, 4 1. DOI: 10.1186/s40064-015-1483-8

Mefloquine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Mefloquine hydrochloride Suppliers

Global( 280)Suppliers
Supplier Tel Email Country ProdList Advantage
Porton Pharma Solutions Ltd.
18883908398 China 56 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		+86-15350851019; +86-15383190639 admin@86-ss.com China 999 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29812 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49979 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32466 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +86-189 4982 3763 sales@tnjchem.com China 34563 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4017 58
Supplier Advantage
Porton Pharma Solutions Ltd.
58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		58
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
TargetMol Chemicals Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58

View Lastest Price from Mefloquine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Mefloquine hydrochloride pictures 2026-07-29 Mefloquine hydrochloride
51773-92-3
 $1.00 1g 99% 10kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Mefloquine hydrochloride pictures 2026-07-28 Mefloquine hydrochloride
51773-92-3
 $800.00-999.00 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Mefloquine hydrochloride pictures 2026-07-27 Mefloquine hydrochloride
51773-92-3
 $30.00-54.00 99.99% 10g TargetMol Chemicals Inc.

Mefloquine hydrochloride Spectrum

Mefloquine hydrochloride(51773-92-3)MSMefloquine hydrochloride(51773-92-3)1HNMR

51773-92-3(Mefloquine hydrochloride)Related Search:

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2,8-bis(trifluoromethyl)-alpha-2-piperidinyl-4-quinolinemethanomonohydroch dl-erythro-alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol s*)-(r(+-)-lorid Mefloquin hydrochloride wr14249 (αS)-rel-α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, hydrochloride (1:1) Mefloquine hydrochloride, >=99% (R)-[2,8-Bis(trifluoromethyl)-4-quinolyl]-[(2S)-2-piperidyl]methanol hydrochloride (αS)-rel-α-(2R)-2-Piperidinyl-2,3-bis(trifluoromethyl-4-quinolinemethanol hydrochloride (S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride (R)-[2,8-bis(trifluoromethyl)-4-quinolinyl][(2S)-2-piperidinyl]methanol hydrochloride wr142490 Mefloquine Hydrochloride, USP (R)-[2,8-bis(trifluoroMethyl)quinolin-4-yl](2R)-piperidin-2-ylMethanol (S)-(2,8-bis(trifluoromethyl)quinolin-4-yl)((R)-piperidin-2-yl)methanol hydrochloride MEFLOQUINE HYDROCHLORIDE (AS)-REL-A-(2R)-2-PIPERIDINYL-2,8-BIS(TRIFLUOROMETHYL)-4-QUINOLINEMETHANOL MONOHYDROCHLORIDE (2r)-(+/-)-alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride (2,8-BIS-TRIFLUOROMETHYL-QUINOLIN-4-YL)-PIPERIDIN-2-YL-METHANOL HYDROCHLORIDE(R*,S*) (R*,S*)-(±)-alpha-2-piperidyl-2,8-bis(trifluoromethyl)quinoline-4-methanol monohydrochloride MEFLOQUINE HYDROCHLORIDE EP(CRM STANDARD) (R*,S*)-(+-)-a-2-piperidyl-2,8-bis(trifluoromethyl)quinoline-4-methanol monohydrochloride 4-Quinolinemethanol, 2,8-bis(trifluoromethyl)-alpha-2-piperidinyl-, monohydrochloride, (R*,S*)-, (+-) DL-Erythro-alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol hydrochloride Loriam (R*,S*)-(2,8-Bis-trifluoromethyl-quinolin-4-yl)-piperidin-2-yl-methanol hydrochloride Ro 21-5998/001 Mefloquine Hydrochloride (100 mg) MefloquineHydrochloride> Mefloquine hydrochloride CRS Mefloquine Hydrochloride (Polymorph Form E) 4-Quinolinemethanol, a-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-,monohydrochloride, (aS)-rel- efloquine hydrochloride rel-(S)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((R)-piperidin-2-yl)methanol hydrochloride Mefloquine HCl (Mefloquin) Mefloquine hydrochlorideQ: What is Mefloquine hydrochloride Q: What is the CAS Number of Mefloquine hydrochloride Q: What is the storage condition of Mefloquine hydrochloride Q: What are the applications of Mefloquine hydrochloride Mefloquine Hydrochloride (1379059) (RS)-[2,8-Bis(trifluoromethyl)-4-quinolyl]-(SR)-(2-piperidyl)methanol hydrochloride Mefloquine hydrochloride, 10 mM in DMSO Mefloquine hydrochloride 100 μg/mL in Acetonitrile Mefloquine for system suitability CRS 4-Quinolinemethanol, α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, hydrochloride (1:1), (αS)-rel- Mefloquine HCI MEFLOQUINE HCL 51773-92-3 C17H16F6N2OHCl C17H16F6N2OClH Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals