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2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine structure

CAS No.: 3605-01-4

Chemical Name:: 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

Synonyms: PIRIBEDIL;Piribendyl;ET-495;EU-4200;Pibedil;Piribedi;Pirbedil;Trivastan;Trivastal;PIRIBEDIOL

CBNumber:: CB6261328

Molecular Formula:: C16H18N4O2

Molecular Weight:: 298.34

MDL Number:: MFCD00868264

MOL File:: 3605-01-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-30 10:48:35

Product description	Number	Pack Size	Price
Piribedil >98.0%(GC)(T)	P2054	200mg	$26
Piribedil >98.0%(GC)(T)	P2054	1g	$69
Piribedil ≥98%	30321	100mg	$81
Piribedil ≥98%	30321	250mg	$130
Piribedil ≥98%	30321	500mg	$218
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2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Properties

Melting point	98°
Boiling point	439.76°C (rough estimate)
Density	1.1183 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	7.17±0.10(Predicted)
form	Solid
color	White
Merck	14,7493
InChI	InChI=1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2
InChIKey	OQDPVLVUJFGPGQ-UHFFFAOYSA-N
SMILES	C1(N2CCN(CC3=CC=C4OCOC4=C3)CC2)=NC=CC=N1
CAS DataBase Reference	3605-01-4(CAS DataBase Reference)
FDA UNII	DO22K1PRDJ
ATC code	N04BC08

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

RTECS

UV9704000

HS Code

2933.59.8000

Toxicity

LD50 in mice (mg/kg): 88 i.v., 690 i.p., 1460 orally (Laubie)

NFPA 704

	0
1		0

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine price More Price(74)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	P2054	Piribedil >98.0%(GC)(T)	3605-01-4	200mg	$26	2026-04-30	Buy
TCI Chemical	P2054	Piribedil >98.0%(GC)(T)	3605-01-4	1g	$69	2021-12-16	Buy
Cayman Chemical	30321	Piribedil ≥98%	3605-01-4	100mg	$81	2026-04-30	Buy
Cayman Chemical	30321	Piribedil ≥98%	3605-01-4	250mg	$130	2026-04-30	Buy
Cayman Chemical	30321	Piribedil ≥98%	3605-01-4	500mg	$218	2026-04-30	Buy

Product number	Packaging	Price	Buy
P2054	200mg	$26	Buy
P2054	1g	$69	Buy
30321	100mg	$81	Buy
30321	250mg	$130	Buy
30321	500mg	$218	Buy

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Trivastal, Eutherapie ,France,1969

Uses

Piribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impairment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.

Definition

ChEBI: 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine is a N-arylpiperazine.

Manufacturing Process

To a solution of 21 g of 1-(3':4'-methylenedioxybenzyl)-piperazine in solution in 300 cc of anhydrous xylene there were added 28 g of anhydrous potassium carbonate and then 11.3 g of 2-chloropyrimidine. The suspension was then heated for 9 hours at boiling point (130°C). After this time, the mixture was cooled and extracted several times with 10% hydrochloric acid. The acid solution obtained was washed with ether and then rendered alkaline with potassium carbonate; the oily product which was separated was extracted with chloroform and this, after drying with potassium carbonate and evaporation, gave an oily residue weighing 20 g. By dissolution in boiling ethanol and crystallization, 15 g of crystals melting at 96°C were recovered.

Therapeutic Function

Vasodilator

References

[1] Chemistry - A European Journal, 2015, vol. 21, # 27, p. 9656 - 9661
[2] ChemCatChem, 2014, vol. 6, # 3, p. 808 - 814
[3] Chemistry - A European Journal, 2013, vol. 19, # 11, p. 3665 - 3675
[4] Journal of Organic Chemistry, 2011, vol. 76, # 7, p. 2328 - 2331
[5] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8263 - 8265

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine synthesis

Synthesis of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine from Piperonylic acid and 2-(1-Piperazinyl)pyrimidine

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Preparation Products And Raw materials

Raw materials

2-Chloropyrimidine 1-Piperonylpiperazine 1-Phenyl-1-propanol Piperonylic acid Piperonyl chloride

Piperonyl alcohol 2-(1-Piperazinyl)pyrimidine 4-Bromo-1,2-(methylenedioxy)benzene Pyrimidine, 2-(4-methyl-1-piperazinyl)- (9CI) Piperonyl aldehyde

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Preparation Products

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Suppliers

Global( 225)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20111	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21533	55
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Hefei Hangang Pharmaceutical Technology Co., Ltd.	+8618062405514	ada@ipurechemical.com	China	10224	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34526	58
Chemsigma International Co., Ltd.	+86-2558742998 +86-19951791336	info@chemsigma.com	China	1824	58
Dideu Industries Group Limited	+8617392712697	1022@dideu.com	China	29095	58
AFINE CHEMICALS LIMITED	+86-571-85134551 +86-18958018566	info@afinechem.com	China	15052	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Hefei Hangang Pharmaceutical Technology Co., Ltd.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Chemsigma International Co., Ltd.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58

Uses and Side Effects of Vasodilator Piribedil
Pirbedil, also known as tasuda, Pronoran, Trivastal Retard, is clinically used as peripheral vascular and cerebral vasodilator....
Oct 17,2019

View Lastest Price from 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine USP/EP/BP 3605-01-4	$1.10	1g	99.9%	100 Tons min	Dideu Industries Group Limited
2026-08-20	2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 3605-01-4	$1.00-50.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-07-29	Piribedil 3605-01-4	$35.00-56.00		99.83%	10g	TargetMol Chemicals Inc.

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine USP/EP/BP
3605-01-4
$1.10
99.9%
Dideu Industries Group Limited

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
3605-01-4
$1.00-50.00
99%
Henan Fengda Chemical Co., Ltd

Piribedil
3605-01-4
$35.00-56.00
99.83%
TargetMol Chemicals Inc.

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Spectrum

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine(3605-01-4)¹HNMR

3605-01-4(2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine)Related Search:

4-((4-(2-Pyrimidinyl)-1-piperazinyl)methyl)pyrocatechol hydrochloride hydrate (2:4:1) Piribedil-d8 Pirenoxine Entacapone CYCLAZOSIN HYDROCHLORIDE

Gabapentin PIRIBEDIL HYDROCHLORIDE 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 2-(4-[1,3-BENZODIOXOL-5-YLMETHYL]-1-PIPERAZINYL)PYRIMIDINE MALEATE SALT 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(3,4-DIMETHOXYPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE

2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-4-METHYL-7-(THIOPHEN-2-YL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]-7-[(E)-2-PHENYLETHENYL]-7,8-DIHYDRO-5(6H)-QUINAZOLINONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(FURAN-2-YL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(4-ISOPROPYLPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(2-CHLOROPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE

2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)PIPERAZIN-1-YL]-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(4-ISOPROPYLPHENYL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE

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2-(4-(benzo[d][1,3]dioxol-5-ylMethyl)piperazin-1-yl)pyriMidine 1-(2-Pyrimidyl)-4-piperonylpiperazine PIRIBEDIL(FORR&DONLY0 PIRIBEDIOL ET-495 EU-4200 Trivastal Trivastan 2-(4-Piperonyl-1-piperazinyl)-Pyrimidine 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Pipidil Control Piribedil> Pyrimidine, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]- PIRIBEDIL USP/EP/BP 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine USP/EP/BP Piribedi Pirbedil Piribedil, 10 mM in DMSO 2-[4-(1,3-benzenebenzometadioxyclopentylene-5-ylmethyl)azine-1-yl]pyrimidine PIRIBEDIL Piribendyl Pibedil 3605-01-4 3605/1/4 622744 Isotope labelled API API