7-Bromo-1-hydroxyisoquinoline
- CAS No.
- 223671-15-6
- Chemical Name:
- 7-Bromo-1-hydroxyisoquinoline
- Synonyms
- 7-broMoisoquinolin-1(2H)-one;7-bromoisoquinolin-1-ol;7-Bromoiso;7-Bromoisocarbostyril;7-BroMoisoquinolin-1-one;7-Bromo-1-hydroxyisoquinoL;7-Bromo-1(2H)-isoquinolinone;7-Bromo-1-hydroxyisoquinoline;1(2H)-Isoquinolinone, 7-bromo-;7-bromo-1-hydroxyisoquinoline 95%
- CBNumber:
- CB6267355
- Molecular Formula:
- C9H6BrNO
- Molecular Weight:
- 224.05
- MDL Number:
- MFCD02093963
- MOL File:
- 223671-15-6.mol
- MSDS File:
- SDS
| Melting point | 248-250°C |
|---|---|
| Boiling point | 427.5±45.0 °C(Predicted) |
| Density | 1.620±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 12.34±0.20(Predicted) |
| form | solid |
| color | Off-white to light yellow |
| Water Solubility | Slightly soluble in water. |
| BRN | 8405244 |
| InChI | InChI=1S/C9H6BrNO/c10-7-2-1-6-3-4-11-9(12)8(6)5-7/h1-5H,(H,11,12) |
| InChIKey | DSOKREQUHLPVFR-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=CC(Br)=C2)C=CN1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-41-37/38-22 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933499090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
7-Bromo-1-hydroxyisoquinoline price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 749559 | 7-bromo-1-hydroxyisoquinoline 95% | 223671-15-6 | 500mg | $69.1 | 2023-06-20 | Buy |
| AstaTech | 51830 | 7-BROMOISOQUINOLIN-1(2H)-ONE 97% | 223671-15-6 | 1G | $48 | 2026-04-30 | Buy |
| AstaTech | 51830 | 7-BROMOISOQUINOLIN-1(2H)-ONE 97% | 223671-15-6 | 5G | $170 | 2026-04-30 | Buy |
| AstaTech | 51830 | 7-BROMOISOQUINOLIN-1(2H)-ONE 97% | 223671-15-6 | 25G | $625 | 2026-04-30 | Buy |
| Apolloscientific | OR300047 | 7-Bromo-1-hydroxyisoquinoline >98% | 223671-15-6 | 250mg | $21 | 2026-06-04 | Buy |
7-Bromo-1-hydroxyisoquinoline Chemical Properties, Uses, Production
Uses
7-Bromo-1-hydroxyisoquinoline acts as a pharmaceutical intermediate. It is also used to prepare 1-amino-4-bromoisoquinoline.
Synthesis
215453-51-3
223671-15-6
7-Bromo-1-chloroisoquinoline (1a, 2.70 g, 11.10 mmol) was used as starting material, which was dissolved in acetic acid (50 mL), followed by the addition of ammonium acetate (1b, 8.50 g, 111.10 mmol). The reaction mixture was placed in an oil bath at 100 °C and the reaction was stirred for 4 hours. After completion of the reaction, the reaction mixture was concentrated to dryness by rotary evaporator. An appropriate amount of water was added to the residue and a white solid precipitated. The solid product was collected by filtration and washed with water to afford 7-bromoisoquinolin-1(2H)-one (1c, 2.7 g, white solid). The crude product was used directly in the subsequent reaction without further purification. Mass spectrum (ESI) m/z: 225.9 [M + 1]+. 1H NMR (400 MHz, CDCl3) δ: 8.55 (d, J = 1.8 Hz, 1H), 7.75 (dd, J = 2.1, 8.5 Hz, 1H), 7.43 (d, J = 8.6 Hz, 1H), 7.14 (d, J = 6.2 Hz, 1H), 6.52 ( d, J = 7.3 Hz, 1H).
References
[1] Chemical Communications, 2018, vol. 54, # 75, p. 10574 - 10577
[2] Patent: EP3042907, 2016, A1. Location in patent: Paragraph 0324; 0325
7-Bromo-1-hydroxyisoquinoline Preparation Products And Raw materials
7-Bromo-1-hydroxyisoquinoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hong-chuang Pharma Tech Co., Ltd. | 18151128828 | hc-sales@foxmail.com | China | 2635 | 55 |
| Suzhou Dongji Chemical Technology Co., Ltd. | 18516099287 | 3045383737@qq.com | China | 230 | 58 |
| Suzhou Sino Rare Chemical Co., Ltd. | 0512-62857507 | sales@sinorarechem.com | China | 999 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
View Latest Price from 7-Bromo-1-hydroxyisoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 7-BROMO-1-HYDROXYISOQUINOLINE
223671-15-6
|
$10.00 | 100KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2020-01-01 | 7-BROMO-1-HYDROXYISOQUINOLINE
223671-15-6
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 7-BROMO-1-HYDROXYISOQUINOLINE
223671-15-6
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 7-BROMO-1-HYDROXYISOQUINOLINE
223671-15-6
- $1.00
- 99%
- Career Henan Chemical Co
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