Tipiracil
- CAS No.
- 183204-74-2
- Chemical Name:
- Tipiracil
- Synonyms
- Tipiracil;MA 1 (pharmaceutical);TPI (thymidine phosphorylase inhibitor);2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidi...;5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione;5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione,;2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-;Tipiracil D4Q: What is Tipiracil D4 Q: What is the CAS Number of Tipiracil D4
- CBNumber:
- CB62744247
- Molecular Formula:
- C9H11ClN4O2
- Molecular Weight:
- 242.66
- MDL Number:
- MFCD17215839
- MOL File:
- 183204-74-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.71±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Water: 1 mg/mL (4.12 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble) |
| form | Solid |
| pka | 7.06±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | NGO10K751P |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
Tipiracil price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5895 | Tipiracil 99.98% | 183204-74-2 | 5mg | $58 | 2026-06-04 | Buy |
| ChemScene | CS-5895 | Tipiracil 99.98% | 183204-74-2 | 10mg | $89 | 2026-06-04 | Buy |
| ChemScene | CS-5895 | Tipiracil 99.98% | 183204-74-2 | 25mg | $136 | 2026-06-04 | Buy |
| ChemScene | CS-5895 | Tipiracil 99.98% | 183204-74-2 | 50mg | $179 | 2026-06-04 | Buy |
| ChemScene | CS-5895 | Tipiracil 99.98% | 183204-74-2 | 100mg | $237 | 2026-06-04 | Buy |
Tipiracil Chemical Properties, Uses, Production
Uses
Tipiracil-13C, 15N2 is carbon-13 and nitrogen-15 labeled Tipiracil,an inhibitor of human thymidine phosphorylase (TP).Thymidine phosphorylase is an enzyme that converts thymidine to thymine and is a platelet-derived endothelial cell growth factor.
Definition
ChEBI: Tipiracil is a member of the class of pyrimidones that is uracil substituted by chloro and (2-iminopyrrolidin-1-yl)methyl groups at positions 5 and 6 respectively. Used (as the hydrochloride salt) in combination with trifluridine, a nucleoside metabolic inhibitor, for treatment of advanced/relapsed unresectable colorectal cancer. It has a role as an antineoplastic agent and an EC 2.4.2.4 (thymidine phosphorylase) inhibitor. It is a pyrimidone, an organochlorine compound, a carboxamidine and a member of pyrrolidines. It is functionally related to a uracil. It is a conjugate base of a tipiracil(1+).
Mode of action
Tipiracil is a thymidine phosphorylase inhibitor. It is used in combination with trifluridine, in a ratio of 1:0.5, to form TAS-102. The main function of Tipiracil in TAS-102 is to increase trifluridine bioavailability by inhibiting its catabolism. TAS-102 is indicated for the treatment of metastatic colorectal cancer which has been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, or with an anti-VEGF or anti-EGFR therapy.
Tipiracil Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Jirun Biomedical Technology Co., Ltd. | 0539-0539-8613587 17661611089 | 2639273505@qq.com | China | 237 | 58 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2986 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Chemleader Biomedical Co., Limited. | 021-58180488 | sales@MedChemLeader.com | China | 1004 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4648 | 60 |
View Latest Price from Tipiracil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Tipiracil
183204-74-2
|
$30.00 | 99.81% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-22 | 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione,
183204-74-2
|
$1.00 | 1g | 85.0-99.8% | 20 tons | Career Henan Chemica Co |
-
- Tipiracil
183204-74-2
- $30.00
- 99.81%
- TargetMol Chemicals Inc.
-
- 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione,
183204-74-2
- $1.00
- 85.0-99.8%
- Career Henan Chemica Co
