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2-Amino-5-chlorobenzophenone

2-Amino-5-chlorobenzophenone Structure
2-Amino-5-chlorobenzophenone structure
CAS No.
719-59-5
Chemical Name:
2-Amino-5-chlorobenzophenone
Synonyms
(2-AMINO-5-CHLOROPHENYL)(PHENYL)METHANONE;ACB;2-Amino-5-chloro;Alprazolam Impurity 4;4-CHLORO-2-BENZOYLANILINE;2-Amino-5-chlorobenophenone;2--5-;NSC 84157;IFLAB-BB F1386-0355;TIMTEC-BB SBB003271
CBNumber:
CB1335583
Molecular Formula:
C13H10ClNO
Molecular Weight:
231.68
MDL Number:
MFCD00007839
MOL File:
719-59-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:28:27
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2-Amino-5-chlorobenzophenone Properties

Melting point 96-98 °C (lit.)
Boiling point 207 °C
Density 1.33
vapor pressure 0-1Pa at 20-25℃
refractive index 1.6000 (estimate)
Flash point 211 °C
storage temp. Store below +30°C.
solubility Solubility in methanol gives very faint turbidity. Soluble in DMSO.
pka 0.06±0.10(Predicted)
form Crystalline Powder
color Yellow
BRN 475640
Stability Stable. Incompatible with strong oxidizing agents.
InChI 1S/C13H10ClNO/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8H,15H2
InChIKey ZUWXHHBROGLWNH-UHFFFAOYSA-N
SMILES Nc1ccc(Cl)cc1C(=O)c2ccccc2
LogP 3.16 at 21℃ and pH7
CAS DataBase Reference 719-59-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII FR80014ZBT
NIST Chemistry Reference Benzophenone, 2-amino-5-chloro-(719-59-5)
EPA Substance Registry System Methanone, (2-amino-5-chlorophenyl)phenyl- (719-59-5)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22-20/21/22
Safety Statements  26-36
WGK Germany  3
RTECS  PC4933500
TSCA  TSCA listed
HS Code  29223900
Storage Class 11 - Combustible Solids
Hazard Classifications Aquatic Acute 1
Aquatic Chronic 1
Toxicity LD50 orally in Rabbit: 10000 mg/kg
REACH Registrations Active
NFPA 704
0
2 0

2-Amino-5-chlorobenzophenone price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A45564 2-Amino-5-chlorobenzophenone 98% 719-59-5 25g $50.5 2026-04-30 Buy
Sigma-Aldrich 1022808 2-Amino-5-chlorobenzophenone United States Pharmacopeia (USP) Reference Standard 719-59-5 25mg $1390 2026-04-30 Buy
TCI Chemical A0079 2-Amino-5-chlorobenzophenone >98.0%(T) 719-59-5 25g $60 2026-04-30 Buy
TCI Chemical A0079 2-Amino-5-chlorobenzophenone >98.0%(T) 719-59-5 500g $713 2026-04-30 Buy
Cayman Chemical 37875 2-Amino-5-chlorobenzophenone ≥98% 719-59-5 1mg $51 2026-04-30 Buy
Product number Packaging Price Buy
A45564 25g $50.5 Buy
1022808 25mg $1390 Buy
A0079 25g $60 Buy
A0079 500g $713 Buy
37875 1mg $51 Buy

2-Amino-5-chlorobenzophenone Chemical Properties,Uses,Production

Chemical Properties

yellow powder

Uses

A metabolite of Diazepam; it had a much weaker anticonvulsant effect.

Uses

It is used in the heterocyclic syntheses based on the reactions of dimethyl acetylenedicarboxylate.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 6811, 1994 DOI: 10.1016/0040-4039(94)85011-9

General Description

2-Amino-5-chlorobenzophenone is a organic nonlinear optical material.

Synthesis

5-CHLORO-3-PHENYLANTHRANIL

719-64-2

2-Amino-5-chlorobenzophenone

719-59-5

(2) 10.0 g of intermediate (II) was added to a three-necked flask containing 50 mL of ethanol, 4.8 g of iron powder was added, and refluxed for 0.5 hours. Subsequently, 1 mL of 6 mol/L sulfuric acid solution was slowly added dropwise. After the dropwise addition, the reaction was continued to reflux for 1 hour. After the reaction was completed, the pH of the reaction solution was adjusted to 8 with NaOH solution and cooled to 50 °C. Add 0.2 g of activated carbon and reflux for 0.5 h. Perform hot filtration into a crystallization flask and cool the crystals. The crystals were washed with ethanol and dried to give 9.60 g of intermediate (III) in 95.1% yield, melting point 96.3-98.2 °C.

References

[1] Journal of Chemical Research - Part S, 2002, # 12, p. 601 - 603
[2] Patent: CN108250091, 2018, A. Location in patent: Paragraph 0032; 0034; 0040
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994, vol. 33, # 7, p. 690 - 691
[4] Patent: CN106083621, 2016, A. Location in patent: Paragraph 0021-0025
[5] Patent: CN107935872, 2018, A. Location in patent: Paragraph 0034-0063; 0067-0074

2-Amino-5-chlorobenzophenone synthesis

719-64-2
719-59-5
Synthesis of 2-Amino-5-chlorobenzophenone from 5-CHLORO-3-PHENYLANTHRANIL

2-Amino-5-chlorobenzophenone Preparation Products And Raw materials

Raw materials

4-Chloronitrobenzene phenylacetonitrile 2-Furoic acid Glass-lined reaction pot Isoxazole
Zinc chloride Water 4-Chloroaniline Benzoyl chloride Benzamide

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Preparation Products

1-(6-Chloro-2-hydroxy-4-phenyl-quinolin-3-yl)-ethanone Chlordiazepoxide 7-chloro-1,3-dihydro-5-phenyl-2-oxo-2H-1,4-benzodiazepin-3-yl acetate (6-CHLORO-2-METHYL-4-PHENYLQUINOLIN-3-YL)ACETIC ACID 2-AMINO-5-CHLOROBENZOPHENONE OXIME
Demoxepam 6-CHLORO-2-(CHLOROMETHYL)-3-OXIDO-4-PHENYL-QUINAZOLINE Diazapam ETHYL 2-(2-BENZOYL-4-CHLOROANILINO)-2-OXOACETATE 6-Chloro-3-ethoxycarbonyl-2-methyl-4-phenylquinoline
2-amino-5-chloro-alpha-methylbenzhydryl alcohol DIETHYL 2-[(2-BENZOYL-4-CHLOROANILINO)METHYLENE]MALONATE

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2-Amino-5-chlorobenzophenone Suppliers

Global( 640)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai LanRun Chemical Co., Ltd. 021-69515658 ; 69515628 13701998368; longrunchem@163.com China 3776 50
Xiangyang Runtongda Chemical Co., Ltd. 0710-3535121 13508666631 xfurunda@163.com China 21 58
Zhuhai Anzhe Biotechnology Co,Ltd. 13169972583 793448631@qq.com China 2989 58
Hubei Zhonglong Kangsheng Fine Chemical Co., Ltd. 15926260361 1930063008@qq.com China 996 58
Hubei Reaction Technology Co, Ltd 0086-13795397680 12653517@qq.com China 25 58
Wuhan EnTai Technology Development Co,.Ltd 86-27-82330560 2536851935@qq.com China 346 69
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Supplier Advantage
Shanghai LanRun Chemical Co., Ltd. 50
Xiangyang Runtongda Chemical Co., Ltd. 58
Zhuhai Anzhe Biotechnology Co,Ltd. 58
Hubei Zhonglong Kangsheng Fine Chemical Co., Ltd. 58
Hubei Reaction Technology Co, Ltd 58
Wuhan EnTai Technology Development Co,.Ltd 69
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69

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View Lastest Price from 2-Amino-5-chlorobenzophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-5-chlorobenzophenone pictures 2026-09-12 2-Amino-5-chlorobenzophenone
719-59-5
 0.99 RongNa Biotechnology Co.,Ltd
2-Amino-5-chlorobenzophenone pictures 2026-09-11 2-Amino-5-chlorobenzophenone
719-59-5
 $5.00 1KG ≥99% 200mt/year Jinan Finer Chemical Co., Ltd
2-Amino-5-chlorobenzophenone pictures 2026-08-21 2-Amino-5-chlorobenzophenone
719-59-5
 $22.00-29.00 10kg 99.99% 100Tons Hebei Dangtong Import and export Co LTD

2-Amino-5-chlorobenzophenone Spectrum

2-Amino-5-chlorobenzophenone(719-59-5)MS2-Amino-5-chlorobenzophenone(719-59-5)1HNMR2-Amino-5-chlorobenzophenone(719-59-5)13CNMR2-Amino-5-chlorobenzophenone(719-59-5)IR12-Amino-5-chlorobenzophenone(719-59-5)IR22-Amino-5-chlorobenzophenone(719-59-5)Raman

719-59-5(2-Amino-5-chlorobenzophenone)Related Search:

Benzophenone Phenylhydrazine 2-Aminobenzophenone Betaine (3,4-Diaminophenyl)phenylmethanone
4-Chlorobenzophenone Glycine Aminoethoxyvinyl glycine hydrochloride Phenyl valerate 2-Amino-5-chloro-2'-fluorobenzophenone
Pigment Red 202 2-Cyclopropylmethylamino-5-chlorobenzophenone 2-Amino-2',5-dichlorobenzophenone Difluorochloromethane 2-Aminobenzylchloride
2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide 5-Chloro-2-(methylamino)benzophenone Chlordiazepoxide

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5-CHLORO-2-AMINOBENZOPHENONE 4-CHLORO-2-BENZOYLANILINE 2-AMINO-5-CHLOROBENZOPHENONE LABOTEST-BB LT00259286 IFLAB-BB F1386-0355 2-AMINO-5-CHLOROBENZOPHENONE 98% 2--5- 2-Amino-5-chlorobenzophenone ( for ALPRAZOLAM) 2-Amino-5-chlorobenzophenone, 98+% 2-Amino-5-chlorobenzophenone (25 mg) 2-AMino-5-chlorobenzophenone, 98% 100GR TIMTEC-BB SBB003271 2-AMINO-5-CHLOROBENZOPHENONE pure Chlordiazepoxide Impurity Ⅰ:2-Amino-5-chlorobenzophenone Nepafenac Impurity 3 Alprazolam Impurity 5（Alprazolam EP Impurity E） (2-amino-5-chlorophenyl)phenyl-methanon 2-Amino-5-chlorbenzophenon 2-Amino-5-chlorbenzophenone 2-Amino-5-chlorodiphenylone 2-Benzoyl-4-chloroaniline Methanone, (2-amino-5-chlorophenyl)phenyl- 2-AMino-5-chlorobenzylphenone NSC 84157 OxazepaM Benzophenone Benzophenone,2-aMino-5-chloro 2-AMINO-5-CHLOROBENZOPHENONE FOR SYNTHES 2-AMino-5-chlorobenophonene 2-AMino-5-chlorobenzophenone, 98+%, 98+% 2 - aMino - 5 - chlorine diphenyl ketone 2-Amino-5-chlorobenzophenone > Dipotassium clorazepate EP Impurity A Prazepam EP Impurity C Oxazepam EP Impurity D Chlordiazepoxide EP Impurity C Chlordiazepoxide impurity C Estazol Am Intermediate CAS 719-59-5 2-Amino-5-Chlorobenzophenone Alprazolam Impurity 4 (2-Amino-5-chlorophenyl)phenylmethanone (Aminochlorobenzophenone) Chlordiazepoxide Hydrochloride EP Impurity C e . (2-a mi no-5-c h loroph e nyl)ph e nylme th a none Oxazepam EP impurity D (prazolam EP impurity E) 2-Amino-5-chlorodibenzophenone 2-Amino-5-Chlorobenzophenone (Alprazolam Impurity) 2-Amino-5-chlorobenzophenone in methanol Alprazolam Impurity E Prazepam Imp. C (EP), Clorazepate Imp. A (EP), , 2-Amino-5- chloro benzophenone 2-Amino-5-chlorobenzophenone 99.5% (2-AMINO-5-CHLOROPHENYL)(PHENYL)METHANONE 2-Amino-5-chlorobenophenone 2-Amino-5-chloro ACB Amino-5-chlorobenzophenone 719-59-5 H2NC6H3ClCOC6H5 Organic Building Blocks Ketones Building Blocks Carbonyl Compounds