Hydroxy-PEG8-t-butyl ester
- CAS No.
- 1334177-84-2
- Chemical Name:
- Hydroxy-PEG8-t-butyl ester
- Synonyms
- HO-PEG8-CH2CH2COOTBU;OH-PEG8-TBA;HO-PEG8-TBA;HO-PEG8-COOtBu;OH-PEG8-COOtBu;Hydroxy-PEG8-Boc;PEG9-t-butly ester;OH-PEG8-CH2CH2COOtBu;HO-PEG8-t-butyl ester;Alcohol-PEG9-t-Bu Ester
- CBNumber:
- CB62747167
- Molecular Formula:
- C23H46O11
- Molecular Weight:
- 498.6
- MDL Number:
- MFCD11041105
- MOL File:
- 1334177-84-2.mol
- MSDS File:
- SDS
| Boiling point | 549.5±45.0 °C(Predicted) |
|---|---|
| Density | 1.083±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in Water, DMSO, DMF, DCM |
| pka | 14.36±0.10(Predicted) |
| form | Liquid |
| color | Colorless to light yellow |
| InChI | InChI=1S/C23H46O11/c1-23(2,3)34-22(25)4-6-26-8-10-28-12-14-30-16-18-32-20-21-33-19-17-31-15-13-29-11-9-27-7-5-24/h24H,4-21H2,1-3H3 |
| InChIKey | RBRDLMWBCQQRIQ-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCO |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Hydroxy-PEG8-t-butyl ester price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | DPG-5796 | Hydroxy-dPEG®8-t-Butyl Ester | 1334177-84-2 | 100mg | $248 | 2026-06-04 | Buy |
| Biosynth | DPG-5796 | Hydroxy-dPEG®8-t-Butyl Ester | 1334177-84-2 | 1000mg | $450 | 2026-06-04 | Buy |
| ChemScene | CS-0110221 | Hydroxy-PEG8-Boc ≥98% | 1334177-84-2 | 100mg | $17 | 2026-06-04 | Buy |
| ChemScene | CS-0110221 | Hydroxy-PEG8-Boc ≥98% | 1334177-84-2 | 250mg | $24 | 2026-06-04 | Buy |
| ChemScene | CS-0110221 | Hydroxy-PEG8-Boc ≥98% | 1334177-84-2 | 1g | $80 | 2026-06-04 | Buy |
Hydroxy-PEG8-t-butyl ester Chemical Properties,Uses,Production
Purity
＞98%
Description
Hydroxy-PEG8-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Hydroxy-PEG8-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
General Description
Hydroxy-PEG8-t-butyl ester (also known as Hydroxy-PEG8-Boc, Hydroxy-PEG8-Boc, HO-PEG8-CH2CH2COO-tBu and OH-PEG8-TBA, etc.; CAS 1334177-84-2) is a high-purity, monodisperse PEG cross-linking agent featuring terminal hydroxyl (-OH) groups and tert-butyl-protected carboxyl groups. This compound is widely used in the development of PROTACs and antibody-drug conjugates (ADCs) to enhance water solubility, improve biocompatibility, and facilitate sequential biocoupling.
IC 50
PEGs
Hydroxy-PEG8-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Biomatrik (Jiaxing) Inc. | 0573-82623377 18967387295 | sales@biomatrik.cn | China | 50 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Chengdu Pukang Biotechnology Co., Ltd | 18217049878 | cassie.gao@pu-kang.com | China | 480 | 58 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Nanjing Junnahe Biopharmaceutical Co., Ltd | 025-58367986 17351780683 | amy.xiang@ally-chem.com | China | 354 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hunan HuaTeng Pharmaceutical Co., Ltd., | 400-8592883 15367835770 | sales@huatengsci.com | China | 5869 | 58 |
| Shanghai Boka-chem Tech. Inc. | 400-026-1533/(021) 6478-0600 | sales@bokachem.com | China | 876 | 58 |
| Tongling HengYou Biotechnology Co., Ltd. | 021-50426030 13856289449;13124863828 | 2630597085@qq.com | China | 1885 | 55 |
| Borenpharm Co., Ltd | 027-65563561 | sales@borenpharm.com | China | 1245 | 55 |
View Lastest Price from Hydroxy-PEG8-t-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate
1334177-84-2
|
1g | 98% | 1g/bottle, 10g/bottle, 100g/bottle | XIAMEN SINOPEG BIOTECH CO., LTD. | ||
 |
2026-07-24 | OH-PEG8-COOtBu
1334177-84-2
|
1g | 98% | 1g/bottle, 10g/bottle, 100g/bottle | XIAMEN SINOPEG BIOTECH CO., LTD. | ||
 |
2026-01-29 | HO-PEG8-CH2CH2COOtBu
1334177-84-2
|
1g | 98% | 300kg | LAURENT |
-
- tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate
1334177-84-2
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
-
- OH-PEG8-COOtBu
1334177-84-2
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
-
- HO-PEG8-CH2CH2COOtBu
1334177-84-2
- 98%
- LAURENT
