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Hydroxy-PEG4-t-butyl ester

Hydroxy-PEG4-t-butyl ester Structure
Hydroxy-PEG4-t-butyl ester structure
CAS No.
518044-32-1
Chemical Name:
Hydroxy-PEG4-t-butyl ester
Synonyms
tert-Butyl 1-Hydroxy-3,6,9,12-tetraoxapentadecan-15-oate;OH-PEG4-COOtBu;NH2-PEG4-COOtBu;HO-PEG4-CH2CH2COOTBU;OH-PEG4-TBA;HO-PEG4-TBA;HO-PEG4-COOtBu;HO-PEG4-C2COOtBu;PEG5-t-butly ester;OH-PEG4-CH2CH2COOtBu
CBNumber:
CB32747166
Molecular Formula:
C15H30O7
Molecular Weight:
322.39
MDL Number:
MFCD11041117
MOL File:
518044-32-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:11:07
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Hydroxy-PEG4-t-butyl ester Properties

Boiling point 406.8±35.0 °C(Predicted)
Density 1.04746 g/mL
refractive index n/D 1.4492
storage temp. 2-8°C
solubility Soluble in Water, DCM
pka 14.36±0.10(Predicted)
form liquid
color Colorless to Light yellow to Light orange
InChI InChI=1S/C15H30O7/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h16H,4-13H2,1-3H3
InChIKey FJRDXEGYAVAMLB-UHFFFAOYSA-N
SMILES C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCO
UNSPSC Code 51171641
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  WGK 3
HS Code  2918999090
Storage Class 10 - Combustible liquids
NFPA 704
1
0 0

Hydroxy-PEG4-t-butyl ester price More Price(78)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 902586 Hydroxy-PEG4-t-butyl ester 518044-32-1 1g $300 2026-04-30 Buy
Sigma-Aldrich 902586 Hydroxy-PEG4-t-butyl ester 518044-32-1 250mg $74.6 2023-06-20 Buy
TCI Chemical B5901 PEG5-Carboxylic Acid tert-Butyl Ester 518044-32-1 1G $80 2026-04-30 Buy
TCI Chemical B5901 PEG5-Carboxylic Acid tert-Butyl Ester 518044-32-1 5G $270 2026-04-30 Buy
Usbiological 516865 Hydroxy-Peg4-t-butyl ester ≥95% 518044-32-1 1g $349 2026-06-03 Buy
Product number Packaging Price Buy
902586 1g $300 Buy
902586 250mg $74.6 Buy
B5901 1G $80 Buy
B5901 5G $270 Buy
516865 1g $349 Buy

Hydroxy-PEG4-t-butyl ester Chemical Properties,Uses,Production

Description

Hydroxy-PEG4-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC molecules) for targeted protein degradation.

reaction suitability

reagent type: cross-linking reagent

Synthesis

Bis[2-(2-hydroxyethoxy)ethyl] ether

112-60-7

tert-Butyl acrylate

1663-39-4

Hydroxy-PEG4-t-butyl ester

518044-32-1

GENERAL STEPS: A piece of sodium (~1/4 cm) was added to an anhydrous tetrahydrofuran (THF, 125 mL) solution of tetraethylene glycol triacetonide (40.61 mL; 45.64 g; 235 mmol). After the sodium was fully reacted, tert-butyl acrylate (11.98 mL; 10.57 g; 82.5 mmol) was added dropwise over 20 min and the reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the pH was adjusted to 7-8 with 1N NaOH solution and the solvent was subsequently removed under reduced pressure. The residue was dissolved in a mixed solution of saturated NaHCO3 and NaCl (75 mL) and extracted with ethyl acetate (EtOAc, 3 x 100 mL). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered, and the solvent evaporated under reduced pressure to afford tert-butyl-15-hydroxy-4,7,10,13-tetraoxapentadecanoate (21.87 g; 67.8 mmol; 82% yield, based on calculation of tert-butyl acrylate) as a colorless oil. The product was characterized by 1H-NMR (500 MHz, CDCl3, TMS) and 13C{1H}-NMR (126 MHz, CDCl3, TMS) with the following data: 1H-NMR δ [ppm] = 3.77-3.57 (m, 18H, OCH2); 3.01 (bs, 1H, OH); 2.51 (t, 2H, J = 6.6 Hz, CH2COO'Bu); 1.45 (s, 9H, C(CH3)3); 13C{1H}-NMR δ [ppm] = 171.1 (COO); 80.7 (C(CH3)3); 72.6 / 70.8 / 70.7 / 70.6 / 70.5 / 67.0 (OCH2); 61.9 (HOCH2); 36.4 ( CH2CO); 28.2 (C(CH3)3).

IC 50

Non-cleavable Linker; Alkyl/ether; PEGs

References

[1] Synthetic Communications, 2004, vol. 34, # 13, p. 2425 - 2432
[2] Patent: WO2016/146638, 2016, A1. Location in patent: Page/Page column 20
[3] Patent: WO2017/147542, 2017, A2. Location in patent: Paragraph 00162
[4] Patent: WO2018/89373, 2018, A2. Location in patent: Paragraph 0638-0639
[5] Tetrahedron, 2011, vol. 67, # 12, p. 2251 - 2259

Hydroxy-PEG4-t-butyl ester Preparation Products And Raw materials

Raw materials

tetraethylene glycol tert-Butyl acrylate Tetrahydrofuran Sodium

Preparation Products

Bromo-PEG4-t-butyl ester H2N-PEG4-tBu

Hydroxy-PEG4-t-butyl ester Suppliers

Global( 153)Suppliers
Supplier Tel Email Country ProdList Advantage
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 043180534350 19917294565 et@chemextension.com China 4446 58
Hebei led the biological technology co., LTD 0311-89629263; 18032827359 2922659299@qq.com China 65 58
Xi'an Kaixin Biotechnology Co., Ltd 029-68881181 13619217766 3495811982@qq.com China 2816 58
Henan Mengtai Pharmaceutical Technology Co., Ltd 17634413542 1959525201@qq.com China 9011 58
Anhui Yongsheng Pharmaceutical Technology Co., Ltd 3307 18017383231 983544897@qq.com China 941 58
Shanghai Yanfen Biochemical Technology Co.,LTD 13611955358 15002190549 yanfen2023@126.com China 2573 58
Jiangxi Youken Biotechnology Co., Ltd. 15107073929 1150046738@qq.com China 464 58
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Chengdu Pukang Biotechnology Co., Ltd 18217049878 cassie.gao@pu-kang.com China 479 58
Supplier Advantage
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 58
Hebei led the biological technology co., LTD 58
Xi'an Kaixin Biotechnology Co., Ltd 58
Henan Mengtai Pharmaceutical Technology Co., Ltd 58
Anhui Yongsheng Pharmaceutical Technology Co., Ltd 58
Shanghai Yanfen Biochemical Technology Co.,LTD 58
Jiangxi Youken Biotechnology Co., Ltd. 58
Energy Chemical 61
Accela ChemBio Co.,Ltd. 64
Chengdu Pukang Biotechnology Co., Ltd 58

View Lastest Price from Hydroxy-PEG4-t-butyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-butyl 1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate pictures 2026-07-24 tert-butyl 1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate
518044-32-1
 1g 98% 1g/bottle, 10g/bottle, 100g/bottle XIAMEN SINOPEG BIOTECH CO., LTD.
OH-PEG4-COOtBu pictures 2026-07-24 OH-PEG4-COOtBu
518044-32-1
 1g 98% 1g/bottle, 10g/bottle, 100g/bottle XIAMEN SINOPEG BIOTECH CO., LTD.
HO-PEG4-CH2CH2COOtBu pictures 2026-01-28 HO-PEG4-CH2CH2COOtBu
518044-32-1
 1g 98% 300kg LAURENT

Hydroxy-PEG4-t-butyl ester Spectrum

Hydroxy-PEG4-t-butyl ester(518044-32-1)1HNMRHydroxy-PEG4-t-butyl ester(518044-32-1)1HNMR

518044-32-1(Hydroxy-PEG4-t-butyl ester)Related Search:

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HO-PEG6-CH2CH2COOH α,ω-dipropionic acid tetraethylene glycol Bis-PEG6-acid alpha-[3-(1,1-Dimethylethoxy)-3-oxopropyl]-omega-hydroxypoly(oxy-1,2-ethanediyl) HO-PEG8-CH2CH2COOH
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1of4

Hydroxy-PEG-5-t-butyl ester PEG5-t-butly ester Hydroxy-PEG4-t-butly ester OH-PEG4-CH2CH2COOtBu OH-PEG4-TBA HO-PEG4-COOtBu t-Butyl 3-Hydroxy(PEG4)propoinate HYDROXY-PEG4-PROPANOIC ACID T-BUTYL ESTER tert-butyl 3-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)propanoate Hydroxy-PEG4-(CH2)2-Boc 4,7,10,13-Tetraoxapentadecanoic acid, 15-hydroxy-, 1,1-dimethylethyl ester tert-Butyl PEG4 propanoate PEG5-Carboxylic Acid tert-Butyl Ester 1-Hydroxy-3,6,9,12-tetraoxapentadecan-15-oic Acid tert-Butyl Ester HO-PEG4 tert-Butyl Ester Hydroxy-dPEG4-t-butyl ester HO-PEG4-CH2CH2COOtBu /4,7,10,13-Tetraoxapentadecanoic acid, 15-hydroxy-, 1,1-dimethylethyl ester HO-PEG4-TBA HO-PEG4-C2COOtBu Hydroxy-dPEG??-t-butyl ester (QBD-10223) Alcohol-PEG5-t-Bu Ester HO-PEG4-CH2CH2COOTBU NH2-PEG4-COOtBu OH-PEG4-COOtBu tert-Butyl 1-Hydroxy-3,6,9,12-tetraoxapentadecan-15-oate 518044-32-1 peg