2-(3-Amino-4-chloro-benzoyl)benzoic acid
- CAS No.
- 118-04-7
- Chemical Name:
- 2-(3-Amino-4-chloro-benzoyl)benzoic acid
- Synonyms
- 2-(3-AMINO-4-CHLOROBENZOYL)BENZOIC ACID;NH2-CBB;LABOTEST-BB LT00012586;Chlortalidone Impurity 4;Chlortalidone Impurity 14;2-(3-Amino-4-chlorobenzoyl)ben;3-Amino-2-Carboxy-4-Chlorobenzophenone;2-(3-amino-4-chlorobenzoyl)-benzoicaci;2-(4-CHLORO-3-AMINOBENZOYL) BENZOIC ACID;2-(3'-AMINO-4'-CHLOROBENZOYL)BENZOIC ACID
- CBNumber:
- CB6281465
- Molecular Formula:
- C14H10ClNO3
- Molecular Weight:
- 275.69
- MDL Number:
- MFCD00007672
- MOL File:
- 118-04-7.mol
- MSDS File:
- SDS
| Melting point | 181.5-182.0 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Boiling point | 538.6±50.0 °C(Predicted) |
| Density | 1.418±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.24±0.36(Predicted) |
| color | Pale Yellow |
| CAS DataBase Reference | 118-04-7(CAS DataBase Reference) |
| FDA UNII | 25WF7LMF9K |
| EPA Substance Registry System | Benzoic acid, 2-(3-amino-4-chlorobenzoyl)- (118-04-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| TSCA | TSCA listed |
| REACH Registrations | Active |
2-(3-Amino-4-chloro-benzoyl)benzoic acid price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PH011586 | 2-(3-amino-4-chlorobenzoyl)benzoic acid AldrichCPR | 118-04-7 | 500mg | $134 | 2023-06-20 | Buy |
| Usbiological | 260272 | 2-(3'-Amino-4'-chlorobenzoyl)benzoic acid Asreported | 118-04-7 | 2g | $217 | 2026-06-03 | Buy |
| Usbiological | 260272 | 2-(3'-Amino-4'-chlorobenzoyl)benzoic acid Asreported | 118-04-7 | 5g | $319 | 2026-06-03 | Buy |
| TRC | TRC-A603200-5G | 2-(3-Amino-4-chlorobenzoyl)benzoic Acid) | 118-04-7 | 5g | $179 | 2026-06-03 | Buy |
| TRC | TRC-A603200-25G | 2-(3-Amino-4-chlorobenzoyl)benzoic Acid) | 118-04-7 | 25g | $643 | 2026-06-03 | Buy |
2-(3-Amino-4-chloro-benzoyl)benzoic acid Chemical Properties, Uses, Production
Uses
2-(3-Amino-4-chlorobenzoyl)benzoic Acid is a useful synthetic intermediate. It is used to prepare protein kinase C phosphorylates synthetic fluorescent reporter.
Synthesis
85-54-1
118-04-7
A. To a reaction vessel was added 0.23 mol of 2-(4-chloro-3-nitrobenzoyl)benzoic acid, 300 mL of a 35% by mass sodium nitrate solution and 500 mL of a 24% by mass potassium carbonate solution. The temperature of the solution was raised to 60 °C, followed by the addition of 1.31 g of chlorobenzoic acid solution, 0.311 g of cuprous chloride and 0.211 g of potassium iodide. The stirring speed was controlled to 160 rpm and the temperature of the solution was raised to 70 °C and refluxed for 3 hours. B. The reaction solution was cooled to 20 °C and filtered. The filter cake was washed with sodium bisulfite solution with a mass fraction of 52%, then the temperature of the washed solution was raised to 50 °C, 300 mL of ammonium chloride solution with a mass fraction of 37% was added, and stirred for 90 minutes. C. The solution was cooled to 10 °C and filtered by pumping. The filter cake was washed with potassium bromide solution and subsequently dehydrated with anhydrous magnesium sulfate as dehydrating agent to finally obtain 2-(3-amino-4-chlorobenzoyl)benzoic acid (60.30 g, 95% yield).
References
[1] Russian Journal of Organic Chemistry, 2001, vol. 37, # 5, p. 673 - 676
[2] Patent: CN105906521, 2016, A. Location in patent: Paragraph 0019; 0020; 0021; 0022; 0023
[3] Angewandte Chemie - International Edition, 1999, vol. 38, # 18, p. 2777 - 2779
[4] Patent: DE148110,
[5] Journal of Medicinal Chemistry, 1965, vol. 8, p. 691 - 694
2-(3-Amino-4-chloro-benzoyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6741 | 52 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Quzhou Juhua Friendship Co., Ltd | 0570-3066667 | China | 3922 | 58 | |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
| Shanghai YuLue Chemical Co., Ltd. | 021-60345187 13671753212 | lzz841106@aliyun.com | China | 10244 | 55 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
View Latest Price from 2-(3-Amino-4-chloro-benzoyl)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | 2-(3-Amino-4-chlorobenzoyl)benzoic acid
118-04-7
|
$153.49 | 25Kg/Drum | 98.00%HPLC | 1.5tons/month | Asia Chem I and E (Jiangsu) Co Ltd | |
 |
2019-12-25 | 2-(3-Amino-4-chloro-benzoyl)benzoic acid
118-04-7
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 2-(3-Amino-4-chlorobenzoyl)benzoic acid
118-04-7
- $153.49
- 98.00%HPLC
- Asia Chem I and E (Jiangsu) Co Ltd
-
- 2-(3-Amino-4-chloro-benzoyl)benzoic acid
118-04-7
- $1.00
- 99%
- Career Henan Chemical Co
118-04-7 (2-(3-Amino-4-chloro-benzoyl)benzoic acid) Related Search:
1of4
