5-METHOXY-2-NITROPHENOL
- CAS No.
- 704-14-3
- Chemical Name:
- 5-METHOXY-2-NITROPHENOL
- Synonyms
- FR-2322;NSC 1167;TIMTEC-BB SBB008609;2-Nitro-5-methoxyphenol;5-METHOXY-2-NITROPHENOL;5-METHOZY-2-NITROPHENOL;3-Methoxy-6-nitrophenol;3-HYDROXY-4-NITROANISOLE;phenol, 5-methoxy-2-nitro-;5-methoxy-2-nitrophenolate
- CBNumber:
- CB6309385
- Molecular Formula:
- C7H7NO4
- Molecular Weight:
- 169.13
- MDL Number:
- MFCD00100932
- MOL File:
- 704-14-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Methoxy-2-nitrophenol | 436827 | 500mg | $319 |
| 5-Methoxy-2-nitrophenol | 436827 | 1g | $410 |
| 5-Methoxy-2-nitrophenol | TRC-M265535-500MG | 500mg | $65 |
| 5-Methoxy-2-nitrophenol | TRC-M265535-2.5G | 2.5g | $116 |
| 5-Methoxy-2-nitrophenol | TRC-M265535-1G | 1g | $84 |
| More product size | |||
| Melting point | 92-94 °C(lit.) |
|---|---|
| Boiling point | 298.4°C (rough estimate) |
| Density | 1.367 |
| refractive index | 1.5830 (rough estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 6.95±0.13(Predicted) |
| form | Powder or Crystals |
| color | Yellow |
| CAS DataBase Reference | 704-14-3(CAS DataBase Reference) |
| FDA UNII | TQ53BN6LHX |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H318-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 37/38-41-36/37/38 |
| Safety Statements | 26-36-37/39 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29095000 |
5-METHOXY-2-NITROPHENOL price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 436827 | 5-Methoxy-2-nitrophenol | 704-14-3 | 500mg | $319 | 2026-06-03 | Buy |
| Usbiological | 436827 | 5-Methoxy-2-nitrophenol | 704-14-3 | 1g | $410 | 2026-06-03 | Buy |
| TRC | TRC-M265535-500MG | 5-Methoxy-2-nitrophenol | 704-14-3 | 500mg | $65 | 2026-06-03 | Buy |
| TRC | TRC-M265535-2.5G | 5-Methoxy-2-nitrophenol | 704-14-3 | 2.5g | $116 | 2026-06-03 | Buy |
| TRC | TRC-M265535-1G | 5-Methoxy-2-nitrophenol | 704-14-3 | 1g | $84 | 2026-06-03 | Buy |
5-METHOXY-2-NITROPHENOL Chemical Properties,Uses,Production
Chemical Properties
yellow crystals or powder
Uses
5-Methoxy-2-nitrophenol is a reagent in the synthesis of conformationally constrained spirocycles, which are used as CCR1 antagonists. 5-Methoxy-2-nitrophenol is also used in the preparation of phenylsulfonyl aminophenoxybenzoates which can serve as EP1 receptor antagonists.
Synthesis Reference(s)
Synthetic Communications, 23, p. 343, 1993 DOI: 10.1080/00397919308009786
Synthesis
4920-84-7
704-14-3
The general procedure for the synthesis of 5-methoxy-2-nitrophenol from 2,4-dimethoxynitrobenzene was as follows: 2,4-dimethoxynitrobenzene (2.0 g, 10.9 mmol) was dissolved in 360 mL of dichloromethane and cooled to 0 °C. Subsequently, anhydrous aluminum trichloride (2.91 g, 21.3 mmol) was added in batches. The reaction mixture was heated to reflux and kept for 5.5 hours (the color of the reaction solution changed to bright red). After completion of the reaction, it was cooled to room temperature and 10% aqueous hydrochloric acid solution was added slowly and dropwise. The mixture was extracted three times with dichloromethane. The organic layers were combined and dried with anhydrous magnesium sulfate. After concentration under reduced pressure to remove the solvent, the crude product was purified by column chromatography (cyclohexane/ethyl acetate = 10:1) to afford 5-methoxy-2-nitrophenol (11) as a yellow solid (1.64 g, 9.69 mmol, 89% yield).
References
[1] Synthetic Communications, 2009, vol. 39, # 11, p. 2053 - 2057
[2] Synlett, 2015, vol. 26, # 10, p. 1395 - 1397
5-METHOXY-2-NITROPHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2971 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Nanjing jinheyou Trading Co., Ltd. | 15705188088 | admin@jheyou.com | CHINA | 1267 | 58 |
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 900 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
View Lastest Price from 5-METHOXY-2-NITROPHENOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-31 | 5-methoxy-2-nitrophenol
704-14-3
|
20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | ||
 |
2020-01-05 | 5-METHOXY-2-NITROPHENOL
704-14-3
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co | |
 |
2019-11-08 | 5-METHOXY-2-NITROPHENOL
704-14-3
|
1g | 98%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. |
-
- 5-methoxy-2-nitrophenol
704-14-3
- $0.00
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- 5-METHOXY-2-NITROPHENOL
704-14-3
- $1.00
- 99%
- Career Henan Chemical Co
-
- 5-METHOXY-2-NITROPHENOL
704-14-3
- $0.00
- 98%min
- Nanjing jinheyou Trading Co., Ltd.
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