3-Oxo-3-thiophen-2-yl-propionic acid ethyl ester
- CAS No.
- 13669-10-8
- Chemical Name:
- 3-Oxo-3-thiophen-2-yl-propionic acid ethyl ester
- Synonyms
- 3-OXO-3-;BUTTPARK 146\18-24;ETHYL (2-THENOYL)ACETATE;ETHYL-2-THIOPHENOYL-ACETATE;3-oxo-3-(thiophen-2-yl)propionate;Ethyl 3-oxo-3-thien-2-ylpropanoate;Ethyl 3-Oxo-3-(2-thienyl)propionate;ETHYL 3-OXO-3-(2-THIENYL)PROPANOATE;Ethyl 3-oxo-3-thiophen-2-yl-propiote;2-[oxo(thiophen-2-yl)methyl]butanoate
- CBNumber:
- CB6314833
- Molecular Formula:
- C9H10O3S
- Molecular Weight:
- 198.24
- MDL Number:
- MFCD00542649
- MOL File:
- 13669-10-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 24 °C(Solv: ethyl ether (60-29-7)) |
|---|---|
| Boiling point | 130°C/0.3mmHg(lit.) |
| Density | 1.212±0.06 g/cm3(Predicted) |
| refractive index | 1.5400 to 1.5440 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to lump to clear liquid |
| pka | 9.79±0.46(Predicted) |
| color | White or Colorless to Light yellow to Light orange |
| CAS DataBase Reference | 13669-10-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H304 | |||||||||
| Precautionary statements | P501-P331-P301+P310-P405 | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
3-Oxo-3-thiophen-2-yl-propionic acid ethyl ester price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1073 | Ethyl 3-Oxo-3-(2-thienyl)propionate >98.0%(GC) | 13669-10-8 | 200mg | $41 | 2026-04-30 | Buy |
| TCI Chemical | E1073 | Ethyl 3-Oxo-3-(2-thienyl)propionate >98.0%(GC) | 13669-10-8 | 1g | $122 | 2026-04-30 | Buy |
| AstaTech | 60882 | ETHYL (2-THENOYL)ACETATE 97% | 13669-10-8 | 1G | $30 | 2026-04-30 | Buy |
| AstaTech | 60882 | ETHYL (2-THENOYL)ACETATE 97% | 13669-10-8 | 5G | $78 | 2026-04-30 | Buy |
| AstaTech | 60882 | ETHYL (2-THENOYL)ACETATE 97% | 13669-10-8 | 25G | $300 | 2026-04-30 | Buy |
3-Oxo-3-thiophen-2-yl-propionic acid ethyl ester Chemical Properties, Uses, Production
Synthesis
88-15-3
105-58-8
13669-10-8
General procedure for the synthesis of ethyl 3-oxo-3-thiophene-2-yl-propionate from 2-acetylthiophene and diethyl carbonate: Sodium hydride (dispersion in 60% mineral oil, 100 g, 2.5 mol) was washed with anhydrous hexane (2 × 250 mL) under nitrogen protection at room temperature. Subsequently, anhydrous tetrahydrofuran (THF, 340 mL) was added with stirring, followed by the dropwise addition of an anhydrous THF (340 mL) solution of 2-acetylthiophene (136 mL, 1.25 mol) over 20 min. The reaction mixture was slowly warmed to 35 °C and maintained for 30 min. After that, a solution of diethyl carbonate (305.5 mL, 2.5 mol) in anhydrous THF (660 mL) was slowly added over 1 hour. After the reaction was continued for 1 hour, the mixture was cooled to 0-10 °C, the reaction was quenched with water (475 mL) and glacial acetic acid (145 mL) was added. After stirring for 20 minutes, the mixture was returned to room temperature. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (3 x 200 mL). The organic phases were combined, washed with brine (2 x 200 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Ethyl 3-oxo-3-thiophen-2-yl-propionate was obtained as a crude dark orange oil in 98% yield (242.8 g).
References
[1] Patent: WO2004/24708, 2004, A2. Location in patent: Page 18-19
[2] Patent: WO2009/158380, 2009, A1. Location in patent: Page/Page column 57
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 9, p. 3417 - 3427
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 6, p. 1910 - 1915
[5] Bioorganic Chemistry, 2016, vol. 65, p. 82 - 89
3-Oxo-3-thiophen-2-yl-propionic acid ethyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Sci General Material & Chemical Ltd | 021-58388037;21-58388037 13472507714 | 35177634@qq.com;1589045147@qq.com | China | 795 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
View Latest Price from 3-Oxo-3-thiophen-2-yl-propionic acid ethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER
13669-10-8
|
$1.00 | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- 3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER
13669-10-8
- $1.00
- 98%
- Career Henan Chemical Co
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