GRANISETRON-D3
- CAS No.
- 34252-44-3
- Chemical Name:
- GRANISETRON-D3
- Synonyms
- Granisetron ImpurityCl;Granisetron EP impurity G;3-Carboxy-2-methyl-2H-indazole;2-Methylindazole-3-carboxylicAci;2-Methylindazole-3-carboxylic acid;2-Methyl-2H-indazole-3-carboxylic A;Granisetron Hydrochloride Impurity G;2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID;2H-Indazole-3-carboxylic acid,2-methyl-;Granisetron Hydrochloride EP Impurity G
- CBNumber:
- CB6324078
- Molecular Formula:
- C9H8N2O2
- Molecular Weight:
- 176.17
- MDL Number:
- MFCD07368556
- MOL File:
- 34252-44-3.mol
- MSDS File:
- SDS
| Melting point | 217-219 |
|---|---|
| Boiling point | 417.4±18.0 °C(Predicted) |
| Density | 1.35 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.02±0.10(Predicted) |
| color | White to Off-White |
| FDA UNII | 7F74Q4NXW7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-22 | |||||||||
| RIDADR | 2811 | |||||||||
| Hazard Note | Harmful | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
GRANISETRON-D3 price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M313460-50MG | 2-Methylindazole-3-carboxylic Acid | 34252-44-3 | 50mg | $179 | 2026-06-03 | Buy |
| TRC | TRC-M313460-500MG | 2-Methylindazole-3-carboxylic Acid | 34252-44-3 | 500mg | $1266 | 2026-06-03 | Buy |
| TRC | TRC-M313460-100MG | 2-Methylindazole-3-carboxylic Acid | 34252-44-3 | 100mg | $243 | 2026-06-03 | Buy |
| Biosynth | FM25860 | 2-Methylindazole-3-carboxylic acid | 34252-44-3 | 5g | $900 | 2026-06-04 | Buy |
| Biosynth | FM25860 | 2-Methylindazole-3-carboxylic acid | 34252-44-3 | 2g | $900 | 2026-06-04 | Buy |
GRANISETRON-D3 Chemical Properties, Uses, Production
Chemical Properties
White Solid
Uses
2-Methyl-2H-indazole-3-carboxylic acid can be used as a reagent used to synthesize 5-HT2A and 5-HT3 receptor ligands for use in treating CNS-related disorders.
Synthesis
109216-61-7
34252-44-3
(Step 1) Synthesis of 2-methyl-2H-indazole-3-carboxylic acid: 2-methyl-2H-indazole-3-carboxylic acid methyl ester (1.59 g, 8.36 mmol) was dissolved in tetrahydrofuran (85 mL), followed by addition of 0.25 N sodium hydroxide solution (50 mL, 12.5 mmol). The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Water (appropriate amount) was added to the residue, which was then acidified with 1 N hydrochloric acid (50 mL). The precipitate precipitated was collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give 2-methyl-2H-indazole-3-carboxylic acid (1.34 g, 91% yield) as a colorless solid.1H-NMR (DMSO-d6) δ: 4.43 (s, 3H), 7.29 (m, 1H), 7.35 (m, 1H), 7.74 (dd, J = 8.1, 1.0 Hz, 1H), 7.98 (d, J = 8.5 Hz, 1H), 13.59 (broad s, 1H).MS (ESI) m/z 177 (M++1).
References
[1] Journal of Medicinal Chemistry, 1987, vol. 30, # 9, p. 1535 - 1537
[2] Patent: EP1346982, 2003, A1
[3] Letters in Organic Chemistry, 2011, vol. 8, # 10, p. 722 - 727
[4] Patent: WO2008/61688, 2008, A1. Location in patent: Page/Page column 21
GRANISETRON-D3 Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1400 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3982 | 55 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
View Latest Price from GRANISETRON-D3 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-05 | 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID
34252-44-3
|
$3.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID
34252-44-3
- $3.00
- 98%
- Career Henan Chemical Co
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