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Urapidil hydrochloride

Urapidil hydrochloride Structure
Urapidil hydrochloride structure
CAS No.
64887-14-5
Chemical Name:
Urapidil hydrochloride
Synonyms
URAPIDIL HCL;Urapidil hydrochoride;URAPIDIL HYDROCHLORIDE;Eposin Etopophos Vepesid VP16;Urapidil hydrochloride USP/EP/BP;Urapidil HCl,Urapidil Hydrochloride;Urapidil hydrochloride, 10 mM in DMSO;3-methyl-3-hydroxymethyloxyheterocyclobutane;URAPIDIL HYDROCHLORIDE A1 ADRENOCEPTOR A NTAG;6[[3-[4-(O-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYLURACIL HYDROCHLORIDE
CBNumber:
CB6332466
Molecular Formula:
C20H30ClN5O3
Molecular Weight:
423.94
MDL Number:
MFCD00078601
MOL File:
64887-14-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
Urapidil hydrochloride solid U100 100mg $173
Urapidil hydrochloride solid U100 500mg $691
Urapidil (hydrochloride) ≥98% 29004 250mg $81
Urapidil (hydrochloride) ≥98% 29004 500mg $135
Urapidil (hydrochloride) ≥98% 29004 1g $255
More product size
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Urapidil hydrochloride Properties

Melting point 156-1580C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility H2O: soluble
form solid
color white
Water Solubility Soluble to 50 mM in water
InChI InChI=1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H
InChIKey KTMLZVUAXJERAT-UHFFFAOYSA-N
SMILES O(C1C=CC=CC=1N1CCN(CCCNC2=CC(=O)N(C)C(=O)N2C)CC1)C.Cl
FDA UNII PVU92PZO12

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  YQ9862000
NFPA 704
0
2 0

Urapidil hydrochloride price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich U100 Urapidil hydrochloride solid 64887-14-5 100mg $173 2023-06-20 Buy
Sigma-Aldrich U100 Urapidil hydrochloride solid 64887-14-5 500mg $691 2023-06-20 Buy
Cayman Chemical 29004 Urapidil (hydrochloride) ≥98% 64887-14-5 250mg $81 2026-04-30 Buy
Cayman Chemical 29004 Urapidil (hydrochloride) ≥98% 64887-14-5 500mg $135 2026-04-30 Buy
Cayman Chemical 29004 Urapidil (hydrochloride) ≥98% 64887-14-5 1g $255 2026-04-30 Buy
Product number Packaging Price Buy
U100 100mg $173 Buy
U100 500mg $691 Buy
29004 250mg $81 Buy
29004 500mg $135 Buy
29004 1g $255 Buy

Urapidil hydrochloride Chemical Properties,Uses,Production

Description

Urapidil is an antagonist of α1-adrenergic receptors (α1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It selectively binds to α1- over α2-ARs (IC50s = 0.74 and 42 μM, respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s = 0.4, 20.4, and >10 μM, respectively) in rat cortex. Urapidil inhibits cAMP accumulation induced by forskolin in calf hippocampus as a functional model for 5-HT1A receptors (EC50 = 390 nM). It is also a β1-AR antagonist that inhibits the positive chronotropic response induced by isoproterenol in isolated rat atria (pA2 = 6.05). Urapidil (1 μmol/kg, i.v.) lowers mean arterial pressure (MAP) in anesthetized cats, an effect that is reduced by central administration of the 5-HT1A receptor antagonist spiroxatrine.

Chemical Properties

White to Off-White Crystalline Powder

Uses

α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive.

Uses

Antihypertensive;Serotonergic receptor agonist

Uses

a1-Adrenergic antagonist; derivative of Uracil. Antihypertensive

Biological Activity

α 1 -adrenoceptor antagonist and 5-HT 1A receptor agonist (pIC 50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.

Side effects

Side effects that may occur during treatment with uradil antihypertension include dizziness, fatigue, nausea, and light-headedness effects. The increases in systolic blood pressure heart rate caused by three progressive work loads bicycle exercise were not affected during urapidil, A slight reduction in forced expiratory volume was observed in some patients during treatment with beta-blocker. There was no case orthostatic hypotension during urapidil administration, despite its alpha1-blocking action. Side-effects were rare negligible[1].

References

[1] G LEONETTI. Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension.[J]. European Journal of Clinical Pharmacology, 1986, 30 6: 637-640. DOI:10.1007/BF00608208.

Urapidil hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Urapidil hydrochloride Suppliers

Global( 275)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Shengzhiyuan Biotechnology Co., LTD
+86-15064083436 +86-15854929067 szyyy01@163.com China 122 58
Hangzhou Hyper Chemicals Limited 		+86-0086-57187702781 +86-13675893055 info@hyper-chem.com China 309 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10399 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 contact@trustwe.com China 5742 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 marketing1@neostarunited.com China 8827 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17339 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Hefei Hangang Pharmaceutical Technology Co., Ltd. 		+8618062405514 ada@ipurechemical.com China 10224 58
Supplier Advantage
Shandong Shengzhiyuan Biotechnology Co., LTD
58
Hangzhou Hyper Chemicals Limited 		58
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
SIMAGCHEM CORP 		58
TargetMol Chemicals Inc. 		58
Hefei Hangang Pharmaceutical Technology Co., Ltd. 		58

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View Lastest Price from Urapidil hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Urapidil hydrochloride pictures 2026-08-11 Urapidil hydrochloride
64887-14-5
 1KG EP, USP 100ton Hangzhou Hyper Chemicals Limited
Urapidil hydrochloride pictures 2026-07-27 Urapidil hydrochloride
64887-14-5
 $39.00-67.00 99.93% 10g TargetMol Chemicals Inc.
Urapidil hydrochloride pictures 2026-07-27 Urapidil hydrochloride
64887-14-5
 $39.00-67.00 99.93% 10g TargetMol Chemicals Inc.

Urapidil hydrochloride Spectrum

Urapidil hydrochloride(64887-14-5)1HNMR

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6[[3-[4-(O-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYLURACIL HYDROCHLORIDE 6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE 6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE HYDROCHLORIDE URAPIDIL HYDROCHLORIDE URAPIDIL HYDROCHLORIDE A1 ADRENOCEPTOR A NTAG 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione hydrochloride 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-quinone hydrochloride 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione,hydrochloride (1:1) 2,4(1H,3H)-Pyrimidinedione,6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-,hydrochloride ( 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil hydrochloride Urapidil hydrochloride USP/EP/BP Urapidil hydrochoride 3-methyl-3-hydroxymethyloxyheterocyclobutane 6-((3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione hydrochloride Urapidil HCl,Urapidil Hydrochloride Eposin Etopophos Vepesid VP16 2,4(1H,3H)-Pyrimidinedione,6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-,hydrochloride (1:1) Urapidil hydrochloride, 10 mM in DMSO URAPIDIL HCL 64887-14-5 C20H30ClN5O3 C20H29N5O3HCl Adrenoceptor Intermediates & Fine Chemicals Pharmaceuticals 64887-14-5 API