Imazamox
- CAS No.
- 114311-32-9
- Chemical Name:
- Imazamox
- Synonyms
- Raptor;2-(4-Isopropyl-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)-5-(methoxymethyl)nicotinic acid;RPTOR;Sweeper;Odyseey;CL29926;IMAZAMOX;AC299263;KIAA1303;CL 299263
- CBNumber:
- CB6333049
- Molecular Formula:
- C15H19N3O4
- Molecular Weight:
- 305.33
- MDL Number:
- MFCD03427427
- MOL File:
- 114311-32-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 166-167°C |
|---|---|
| Density | 1.39 g/cm3 |
| storage temp. | 0-6°C |
| solubility | DMSO : 20 mg/mL (65.50 mM) |
| pka | pK1 2.3; pK2 3.3(at 25℃) |
| form | Solid |
| color | White to off-white |
| biological source | rabbit |
| Henry's Law Constant | 1.1×1013 mol/(m3Pa) at 25℃, HSDB (2015) |
| Major Application |
agriculture environmental |
| InChI | InChI=1S/C15H19N3O4/c1-8(2)15(3)14(21)17-12(18-15)11-10(13(19)20)5-9(6-16-11)7-22-4/h5-6,8H,7H2,1-4H3,(H,19,20)(H,17,18,21) |
| InChIKey | NUPJIGQFXCQJBK-UHFFFAOYSA-N |
| SMILES | C1(C2NC(=O)C(C)(C(C)C)N=2)=NC=C(COC)C=C1C(O)=O |
| CAS DataBase Reference | 114311-32-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | UG6793ON5F |
| Pesticides Freedom of Information Act (FOIA) | Imazamox |
| EPA Substance Registry System | Imazamox (114311-32-9) |
| UNSPSC Code | 41116107 |
| NACRES | NA.41 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 |
| PPE | Eyeshields, Gloves |
| Hazard Codes | N |
| Risk Statements | 50/53 |
| Safety Statements | 60-61 |
| RIDADR | UN3077 9/PG 3 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 Eye Irrit. 2 Repr. 2 |
| Hazardous Substances Data | 114311-32-9(Hazardous Substances Data) |
| Toxicity | LD50 (technical grade) orally in rats: >5000 mg/kg; dermally in rabbits: >4000 mg/kg; LC50 by inhalation in rats: >6.3 mg/l (Glover) |
Imazamox price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB1305088 | ANTI-PHOSPHO-RAPTOR(S863) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution | 114311-32-9 | 400μl | $532 | 2026-04-30 | Buy |
| Sigma-Aldrich | CRM34227 | Imazamox certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland | 114311-32-9 | 50 mg | $112 | 2026-04-30 | Buy |
| Sigma-Aldrich | 34227 | Imazamox PESTANAL | 114311-32-9 | 100mg | $164 | 2026-04-30 | Buy |
| Sigma-Aldrich | CRM34227 | Imazamox certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland | 114311-32-9 | 1 unit | $104 | 2025-07-31 | Buy |
| Usbiological | 575288 | RPTOR PurifiedbyProteinGaffinitychromatography. | 50ug | $509 | 2026-06-03 | Buy |
Imazamox Chemical Properties, Uses, Production
Description
Imazamox (2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5- (methoxymethyl)-3-pyridinecarboxylic acid) is a systemic herbicide that moves throughout the plant tissue and prevents plants from producing a necessary enzyme, acetolactate synthase (ALS), which is not found in animals. Susceptible plants will stop growing soon after treatment, but plant death and decomposition will occur over several weeks.
Imazamox is used for the control of vegetation in and around aquatic sites and terrestrial non-crop sites. It is herbicidally active on many submerged, emergent, and floating broadleaf and monocot aquatic plants in and around standing and slow- moving water bodies. It is used as herbicide on sunflower seed, alfalfa, oilseed rape and soya bean seed and used for the control of most annual and perennial broadleaf weeds and grasses, woody species, and riparian and emergent aquatic weed species.
Imazamox is only moderately persistent, and it degrades aerobically in the soil to a non-herbicidal metabolite which is immobile or moderately mobile. Imazamox also degrades by aqueous photolysis.
References
[1] http://dnr.wi.gov/lakes/plants/factsheets/ImazamoxFactsheet.pdf
[2] https://www.efsa.europa.eu/en/efsajournal/pub/4432
[3] http://www.mass.gov/eea/docs/agr/pesticides/aquatic/imazamox.pdf
Description
Imazamox is registered throughout the world for use in leguminous crops, including soybeans, alfalfa, and edible beans, as well as in imidazolinone-resistant crops (9). A nonionic surfactant or oil adjuvant is required for maximum activity. Imazamox is much more active when applied post-emergent to the weeds compared with pre-emergence application (9). One difference between imazamox and other imidazolinones is the much shorter interval needed before sensitive follow crops can be planted. This difference is due to the more rapid degradation of imazamox in the soil compared with other imidazolinones.
Chemical Properties
Off-White Solid
Uses
Imazamox is an imidazolinone based acetolactate synthase inhibitor that is utilized as a herbicide for weed control.
Uses
Herbicide.
Definition
ChEBI: 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)-5-(methoxymethyl)nicotinic acid is a pyridinemonocarboxylic acid that is nicotinic acid which is substituted substituted at position 5 by a methoxymethyl group and at position 2 by a 4,5-dihydro-1H-imidazol-2-yl group, that in turn is substituted by isopropyl, methyl, and oxo groups at positions 4, 4, and 5, respectively. It is a pyridinemonocarboxylic acid, an ether, an imidazolone and a member of imidazolines.
Production Methods
The industrial synthesis of imazamox begins with the construction of its imidazolinone core, typically through condensation reactions involving pyridine carboxylic acid derivatives and imidazolinone intermediates. The process includes key steps such as cyclization to form the heterocyclic ring and selective substitution to introduce functional groups that enhance herbicidal activity. Esterification or salt formation may be employed to improve solubility and formulation stability. Reaction conditions, such as temperature, solvent choice, and pH, are carefully optimised to maximise yield and purity while minimising environmental impact.
Mechanism of action
Contact and residual activity. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS.
Pharmacology
Imazamox kills plants by inhibiting acetolactate synthase (ALS) (I50 = 1 μM), which is the first common enzyme in the biosynthesis of the branched chain amino acids, valine, leucine, and isoleucine. Imazamox is rapidly absorbed through the leaves of plants. Once it enters the plant, imazamox rapidly translocates to the growing points and growth ceases within 1 day after herbicide application, followed by chlorosis and then by necrosis of the growing points. Total plant death will occur within 2 to 3 weeks after treatment.
Metabolism
Plant Metabolism. The selectivity of imazamox is due to
differential rates and routes of metabolism in tolerant
crops versus susceptible weeds (10). The primary
metabolic route is hydroxylation followed by conjugation
to glucose. In imidazolinone-resistant crops, the primary
mechanism of selectivity is due to an altered acetolactate
synthase that is not inhibited by imazamox (11).
Animal Metabolism. Metabolism studies in the rat
showed that imazamox is rapidly excreted in the urine.
There was no accumulation of imazamox or any of its
derivatives in the liver, kidney, muscle, fat, or blood (9).
Toxicity evaluation
Imazamox has shown no mutagenic or genotoxic activity in the Ames assay, mammalian cell gene mutation assay, in vitro chromosome aberration assay, in vitro unscheduled DNA synthesis (URS) assay, or the in vivo dominant lethal assay inmale rats. The acute toxicity and effects on wildlife and soilmicroflora of imazamox are shown in Table 4. This herbicide also has a low potential for bioaccumulation in fish.
Pesticide Type
Herbicide
Imazamox Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Taian Jiayue Bio-chemical Co. LTD | 15318151873 | 285424065@qq.com | China | 4541 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Nanjing Kaitian Chemical Co., Ltd. | +86 (25) 5860-8846 | kt_chem@126.com | China | 218 | 62 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2277 | 58 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
View Latest Price from Imazamox manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-23 | Imazamox
114311-32-9
|
$50.00 | 1kg | 99 | 5000 | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2024-12-24 | Imazamox
114311-32-9
|
1g | 99.99% | 20 tons | airuikechemical co., ltd. | ||
 |
2024-05-11 | Imazamox
114311-32-9
|
$10.00-20.00 | 1kg | 98% | 20 | Hebei Kangcang new material Technology Co., LTD |
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