Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2
- CAS No.
- 54784-44-0
- Chemical Name:
- Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2
- Synonyms
- wy-18,185;LHRH, Phe(2)-Ala(6)-;[D-PHE2, D-ALA6]-LH-RH;[D-PHE2, D-ALA6]-LH-RH (HUMAN);(d-phe(sup2))-(d-ala(sup6))-lhrh;D-PHE2 D-ALA6-LUTEINIZING HORMONE &;GLP-DPHE-TRP-SER-TYR-DALA-LEU-ARG-PRO-GLY-NH2;PYR-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2;Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2;D-phe2,D-ala6-luteinizing hormone*releasing hormo
- CBNumber:
- CB6337481
- Molecular Formula:
- C59H79N15O13
- Molecular Weight:
- 1206.35
- MDL Number:
- MFCD00079994
- MOL File:
- 54784-44-0.mol
- TDS File:
- TDS
| storage temp. | −20°C |
|---|---|
| FDA UNII | 0CH971OO9V |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360 |
| Hazard Codes | T |
| Risk Statements | 60 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | OK6600000 |
Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA00D85E | PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 >96% | 54784-44-0 | 5mg | $282 | 2026-05-28 | Buy |
| American Custom Chemicals Corporation | PEP0005623 | PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 95.00% | 54784-44-0 | 5MG | $497.77 | 2021-12-16 | Buy |
Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 Chemical Properties, Uses, Production
Uses
[D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities[1].
in vivo
[D-Phe2,D-Ala6]-LH-RH inhibits the LH and FSH release induced by LH-RH in immature male rats[1].
[D-Phe2,D-Ala6]-LH-RH (1 mg/rat, SC) shows marked antiovulatory and contraceptive activity[2].
[D-Phe2,D-Ala6]-LH-RH (0.625, 1.25, 2.5 mg/kg; s.c.; single dose; sacrificed 30 minutes) results a dose-dependent increase in stalk-median eminence (SME)-LHRH activity and decreases plasma LHRH activity as well in rats with hypophysectomized (hypox) at 25 days old[3].
[D-Phe2,D-Ala6]-LH-RH (25 mg/kg; s.c.; single dsoe) is effective in blocking the ovulation normally induced by LRH alone[4].
| Animal Model: | Adult female Sprague-Dawley rats (200-250 g)[2] |
| Dosage: | 1 mg/rat |
| Administration: | SC injections, from 12:00 to 14:30 hr on the day of proestrus |
| Result: | Showed marked antiovulatory and contraceptive activity, with 96% inhibition of ovulation. |
References
[1] Vilchez-Martinez JA, et al. Comparison of the anti-LH/FSH-RH and anti-ovulatory activities of (D-Phe2, D-Leu6)-LH-RH and (D-Phe2, D-Ala6)-LH-RH. Endocr Res Commun. 1976;3(3-4):231-41. DOI:10.3109/07435807609056903
[2] Beattie CW, et al. Luteinizing hormone-releasing hormone. Antiovulatory activity of analogs substituted in positions 2 and 6. J Med Chem. 1975 Dec;18(12):1247-50. DOI:10.1021/jm00246a016
[3] Corbin A, et al. Effect of luteinizing hormone releasing hormone (LHRH) and an LHRH antagonist of hypothalamic and plasma LHRH of hypophysectomized rats. Endocrinology. 1976 Jan;98(1):247-50. DOI:10.1210/endo-98-1-247
[4] Corbin A, et al. Ihibition of the pre-ovulatory proestrous gonadotropin surge, ovulation and pregnancy with a peptide analogue of luteinizing hormone releasing hormone. Endocr Res Commun. 1975;2(1):1-23. DOI:10.3109/07435807509053836
Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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