E3 ligase Ligand-Linker Conjugates 11
- CAS No.
- 1835705-61-7
- Chemical Name:
- E3 ligase Ligand-Linker Conjugates 11
- Synonyms
- (S,R,S)-AHPC-6-5-6-Cl;(S,R,S)-AHPC-(C3-PEG)2-C6-C;VHL Ligand-Linker Conjugates 11;E3 ligase Ligand-Linker Conjugates 11;(S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride;(S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride;L-Prolinamide, N-[6-[[5-[(6-chlorohexyl)oxy]pentyl]oxy]-1-oxohexyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-[(2S)-2-[6-({5-[(6-chlorohexyl)oxy]pentyl}oxy)hexanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
- CBNumber:
- CB63386464
- Molecular Formula:
- C39H61ClN4O6S
- Molecular Weight:
- 749.44
- MDL Number:
- MFCD31560481
- MOL File:
- 1835705-61-7.mol
- MSDS File:
- SDS
| Boiling point | 921.3±65.0 °C(Predicted) |
|---|---|
| Density | 1.152±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 14.08±0.40(Predicted) |
| form | Solid |
| color | Off-white to yellow |
| SMILES | ClCCCCCCOCCCCCOCCCCCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O |
| UNSPSC Code | 12352101 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 13 - Non Combustible Solids |
E3 ligase Ligand-Linker Conjugates 11 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 905402 | (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride 95% | 1835705-61-7 | 50MG | $559 | 2023-06-20 | Buy |
| Biosynth | KYC70561 | (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride | 1835705-61-7 | 100mg | $995 | 2026-06-04 | Buy |
| Biosynth | KYC70561 | (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride | 1835705-61-7 | 250mg | $1620 | 2026-06-04 | Buy |
| ChemScene | CS-7751 | (S,R,S)-AHPC-(C3-PEG)2-C6-Cl ≥98% | 1835705-61-7 | 100mg | $550 | 2026-06-04 | Buy |
| ChemScene | CS-7751 | (S,R,S)-AHPC-(C3-PEG)2-C6-Cl ≥98% | 1835705-61-7 | 500mg | $1950 | 2026-06-04 | Buy |
E3 ligase Ligand-Linker Conjugates 11 Chemical Properties, Uses, Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
reaction suitability
reactivity: sulfuryl reactive
reagent type: ligand-linker conjugate
IC 50
VHL
E3 ligase Ligand-Linker Conjugates 11 Preparation Products And Raw materials
Raw materials
Preparation Products
E3 ligase Ligand-Linker Conjugates 11 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4229 | 58 |
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1644 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39796 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 9067 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | Gsiyu@solarbio.com | China | 50460 | 58 |
View Latest Price from E3 ligase Ligand-Linker Conjugates 11 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | (S,R,S)-AHPC-(C3-?PEG)?2-?C6-?Cl
1835705-61-7
|
$61.00-98.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-06-07 | (S,R,S)-AHPC-6-5-6-Cl
1835705-61-7
|
1g | >95.00% | 1g | Xian confluore Biological Technology Co., Ltd. |
-
- (S,R,S)-AHPC-(C3-?PEG)?2-?C6-?Cl
1835705-61-7
- $61.00-98.00
- TargetMol Chemicals Inc.
-
- (S,R,S)-AHPC-6-5-6-Cl
1835705-61-7
- $0.00
- >95.00%
- Xian confluore Biological Technology Co., Ltd.
