Dimethyl acetylmethylphosphonate
- CAS No.
- 4202-14-6
- Chemical Name:
- Dimethyl acetylmethylphosphonate
- Synonyms
- DIMETHYL (2-OXOPROPYL)PHOSPHONATE;1-Dimethoxyphosphorylpropan-2-one;DIMETHYL ACE;LABOTEST-BB LT00847718;Dimethyl(2-oxopropyl)phosph;DIMETHYL ACETONYLPHOSPHONATE;Dimethyl acetylmethylphosphote;DIMETHYL ACETYLMETHYLPHOSPHONATE;Dimethyl-(2-oxopropyl)phosphonat;Dimethyle(2-oxopropyl)phosphonate
- CBNumber:
- CB6339733
- Molecular Formula:
- C5H11O4P
- Molecular Weight:
- 166.11
- MDL Number:
- MFCD00008769
- MOL File:
- 4202-14-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 76-79 °C3 mm Hg(lit.) |
|---|---|
| Density | 1.202 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 200 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Difficult to mix. |
| form | Liquid |
| color | Clear colorless to light brown |
| BRN | 1766218 |
| InChI | InChI=1S/C5H11O4P/c1-5(6)4-10(7,8-2)9-3/h4H2,1-3H3 |
| InChIKey | UOWIYNWMROWVDG-UHFFFAOYSA-N |
| SMILES | P(CC(=O)C)(=O)(OC)OC |
| CAS DataBase Reference | 4202-14-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Dimethyl (2-oxopropyl)phosphonate(4202-14-6) |
| UNSPSC Code | 12352108 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227 | |||||||||
| Precautionary statements | P210e-P280a-P370+P378a-P501a-P210-P280-P403+P235-P501 | |||||||||
| PPE | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 23-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29310095 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| NFPA 704 |
|
Dimethyl acetylmethylphosphonate price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 180696 | Dimethyl 2-oxopropylphosphonate 95% | 4202-14-6 | 5g | $36.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 180696 | Dimethyl 2-oxopropylphosphonate 95% | 4202-14-6 | 25g | $173 | 2026-04-30 | Buy |
| TCI Chemical | O0208 | Dimethyl (2-Oxopropyl)phosphonate >95.0%(GC) | 4202-14-6 | 5g | $55 | 2026-04-30 | Buy |
| TCI Chemical | O0208 | Dimethyl (2-Oxopropyl)phosphonate >95.0%(GC) | 4202-14-6 | 25g | $222 | 2026-04-30 | Buy |
| Usbiological | 274695 | Dimethyl acetylmethylphosphonate Asreported | 4202-14-6 | 2g | $333 | 2026-06-03 | Buy |
Dimethyl acetylmethylphosphonate Chemical Properties, Uses, Production
Chemical Properties
CLEAR COLOURLESS TO LIGHT BROWN LIQUID
Uses
Dimethyl acetylmethylphosphonate is a Reagent used together with tosyl azide in a one-pot alkynylation of aldehydes.
Synthesis Reference(s)
Tetrahedron Letters, 17, p. 2829, 1976 DOI: 10.1016/S0040-4039(01)85513-1
reaction suitability
reaction type: C-C Bond Formation
Synthesis
78-95-5
121-45-9
4202-14-6
General procedure for the synthesis of dimethyl acetone-based phosphonate from chloroacetone and trimethoxyphosphine: a dry and clean 500 mL coil was heated to 135 °C. 1000 g (0.7 eq., 10.81 mol) of chloroacetone (boiling point 117 to 119 °C at standard atmospheric pressure) was placed in charge bottle A and diluted with 4000 g of toluene. 1878 g (1.0 eq., 15.13 mol) of trimethoxyphosphine (boiling point at 112°C at standard atmospheric pressure) was placed in charge bottle B and diluted with 3122 g of toluene. After the temperature was stabilized, batch pumping of the chloroacetone-toluene solution in Bottle A and the trimethoxyphosphine-toluene solution in Bottle B was started at a rate of 12.5 g/min. The residence time of the reactants was 20 min, and the reaction pressure was maintained at 0.5 to 2.0 MPa. The reacted mixture was directly introduced into a thin-film evaporation unit, with a controlled pressure of 4 to 10 x 10^2 Pa and a temperature of between 60 and 70 °C. The reaction was carried out at a pressure of 4 to 10 x 10^2 Pa. Ultimately, 1230 g of dimethyl acetone-based phosphonate (boiling point 85 to 88 °C, 666 Pa) was obtained in 88% yield.
References
[1] Patent: CN107163079, 2017, A. Location in patent: Paragraph 0076; 0077; 0078
[2] Organic Letters, 2015, vol. 17, # 5, p. 1308 - 1311
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 21, p. 8765 - 8780
[4] Journal of the American Chemical Society, 1995, vol. 117, # 10, p. 2931 - 2932
[5] Organic and Biomolecular Chemistry, 2017, vol. 15, # 15, p. 3304 - 3309
Dimethyl acetylmethylphosphonate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai AmasPharm Co., Ltd. | 021-54540637 18621091017 | sales@amaspharm.com | China | 787 | 62 |
| Sci General Material & Chemical Ltd | 021-58388037;21-58388037 13472507714 | 35177634@qq.com;1589045147@qq.com | China | 795 | 55 |
| JINAN MEIGAO BIOPHARMATECH CO. LTD | 13853286203 18205419756 | shy96321@163.com | China | 20 | 58 |
| Qingdao Port Liwei Import and Export Co., Ltd | 13853286203 13853286203 | shy96321@163.com | China | 40 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from Dimethyl acetylmethylphosphonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | Dimethyl acetonylphosphonate
4202-14-6
|
$1.00-35.00 | 1KG | 99% | 350000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-08-07 | DiMethyl (2-oxopropyl)phosphonate
4202-14-6
|
$1.00 | 1KG | 99% | 20 Tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-04-04 | Dimethyl acetylmethylphosphonate
4202-14-6
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Dimethyl acetonylphosphonate
4202-14-6
- $1.00-35.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- DiMethyl (2-oxopropyl)phosphonate
4202-14-6
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Dimethyl acetylmethylphosphonate
4202-14-6
- 98%
- Henan Aochuang Chemical Co.,Ltd.
