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4,4'-Oxydiphthalic anhydride

4,4'-Oxydiphthalic anhydride Structure
4,4'-Oxydiphthalic anhydride structure
CAS No.
1823-59-2
Chemical Name:
4,4'-Oxydiphthalic anhydride
Synonyms
ODPA;4,4'-Oxydiphthalic dianhydride;s-ODPA;4,4'-Oxydiphthalic Acid;4,4-Oxydiphthalic anhydride;5,5'-Oxybis(isobenzofuran-1,3-dione);FCK;BIS-(3-PHTHALYL ANHYDRIDE) ETHER;FFCF;Bis-(3-phthalyl anhy
CBNumber:
CB6372079
Molecular Formula:
C16H6O7
Molecular Weight:
310.21
MDL Number:
MFCD00039144
MOL File:
1823-59-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:24:02
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4,4'-Oxydiphthalic anhydride Properties

Melting point 225-229 °C(lit.)
Boiling point 410.39°C (rough estimate)
Density 1.4942 (rough estimate)
refractive index 1.6380 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility very slightly in Toluene,Acetone
form powder to crystal
color White to Light yellow to Light orange
InChI InChI=1S/C16H6O7/c17-13-9-3-1-7(5-11(9)15(19)22-13)21-8-2-4-10-12(6-8)16(20)23-14(10)18/h1-6H
InChIKey QQGYZOYWNCKGEK-UHFFFAOYSA-N
SMILES O(C1C=CC2C(=O)OC(=O)C=2C=1)C1C=CC2C(=O)OC(=O)C=2C=1
CAS DataBase Reference 1823-59-2(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII G58E17X7VE
NIST Chemistry Reference Bis-(3-phthalyl anhydride) ether(1823-59-2)
EPA Substance Registry System 1,3-Isobenzofurandione, 5,5'-oxybis- (1823-59-2)
UNSPSC Code 12162002
NACRES NA.23

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H412
Precautionary statements  P273
PPE Eyeshields, Gloves
Risk Statements  52/53
Safety Statements  61
WGK Germany  2
TSCA  TSCA listed
HS Code  29189900
Storage Class 11 - Combustible Solids
Hazard Classifications Aquatic Chronic 3
REACH Registrations Active
NFPA 704
0
1 0

4,4'-Oxydiphthalic anhydride price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 524492 4,4′-Oxydiphthalic anhydride 97% 1823-59-2 25g $234 2026-04-30 Buy
TCI Chemical O0237 4,4'-Oxydiphthalic Anhydride >98.0%(HPLC) 1823-59-2 25g $59 2026-04-30 Buy
TCI Chemical O0237 4,4'-Oxydiphthalic Anhydride >98.0%(HPLC) 1823-59-2 100g $192 2026-04-30 Buy
Biosynth FO62671 4,4'-Oxydiphthalic anhydride 1823-59-2 0.1kg $267.49 2026-06-04 Buy
Biosynth FO62671 4,4'-Oxydiphthalic anhydride 1823-59-2 0.25kg $501.55 2026-06-04 Buy
Product number Packaging Price Buy
524492 25g $234 Buy
O0237 25g $59 Buy
O0237 100g $192 Buy
FO62671 0.1kg $267.49 Buy
FO62671 0.25kg $501.55 Buy

4,4'-Oxydiphthalic anhydride Chemical Properties, Uses, Production

Description

4,4'-Oxydiphthalic anhydride/ODPA(CAS:1823-59-2) is a solid, melts in the range of 225-229 °C and was first introduced in the mid-1980s, offering a greater degree of flexibility than other commercial dianhydrides. It also is somewhat less reactive than BTDA.  ODPA has largely been used in polyimides and much less so in epoxies. It imparts special performance properties in free films and in FCCL production for high-end personal electronic devices.

Chemical Properties

off-white to white powder

Uses

4,4'-oxydiphthalic anhydride be used for the preparation of a polyimide material.

Preparation

The preparation of 4,4'-Oxydiphthalic anhydride is as follows:Chlorophthalic anhydride (30g, 160mmol), tetraphenyl phosphonium bromide (0.3g, 0.7mmol), and 2,5-dichlorobenzoic acid (0.08g, 0.4mmol) were heated to approximately 220℃. Potassium carbonate (7.95g, 58mmol) was added over 45 minutes. The reaction was sampled after addition of the potassium carbonate and showed a 24.9% conversion to 4,4'-oxydiphthalic anhydride. The reaction was heated for an additional 45 minutes. The reaction mixture was diluted with 1,2,4-trichlorobenzene (90g) and filtered. The 4,4'-oxydiphthalic anhydride was allowed to crystallize and was collected, washed with 1,2,4-trichlorobenzene followed by hexane, and dried in an air circulating oven at 120℃. to give crude 4,4'-oxydiphthalic anhydride, 12.9g.

1823-59-2.png

Flammability and Explosibility

Not classified

Synthesis

4-Chlorophthalic anhydride

118-45-6

4,4'-Oxydiphthalic anhydride

1823-59-2

The general procedure for the synthesis of 4,4'-oxybisphthalic anhydride from 4-chlorophthalic anhydride is as follows: 1. 4-chlorophthalic anhydride (16 g, 87.7 mmol) was added to a 150 ml three-necked flask fitted with a distillation head, which was pre-filled with about 100 ml of distilled o-dichlorobenzene containing less than 5 ppm of water. 2. The mixture was heated to reflux for 0.5 h under nitrogen protection, followed by distillation to remove about 80 ml of o-dichlorobenzene. 3. To another flask was added powdered potassium carbonate (6.06 g, 43.8 mmol) and 50 ml of anhydrous o-dichlorobenzene. 4. The suspension was heated to reflux for 0.5 h under nitrogen protection and 40 ml of o-dichlorobenzene was distilled. 5. The 4-chlorophthalic anhydride solution prepared in step 1 was transferred to a flask containing potassium carbonate. 6. The mixture was stirred, hexaethylguanidine chloride (468 mg, 1.77 mmol, as an 18% solution in o-dichlorobenzene containing less than 15 ppm of water) was added and refluxing was continued, observing a gradual change in color of the solution to yellow. 7. The mixture was analyzed periodically and 93% yield of 4,4'-oxybisphthalic anhydride was achieved after 3 hours. 8. in a control experiment using the same molar percentage of tetraphenylphosphonium bromide and powdered potassium carbonate it took 13 hours to achieve the same yield. 9. Repeating the experiment, switching to granular potassium carbonate and adjusting the amount of hexaethylguanidine chloride to 2.0 mol% of 4-chlorophthalic anhydride, the product formation was stabilized after 3 hours in an overall yield of about 85% or better. Note: The above description and embodiments are for illustrative purposes only and should not be regarded as a limitation of the present invention. Various modifications, adaptations and substitutions may be made by those skilled in the art without departing from the spirit and scope of the present invention.

IC 50

HepG2: IC50 = 121 μM (human); SK-HEP1: IC50 = 199 μM (human); Hepatocyte: IC50 >200 μM (rat)

References

[1] Patent: US6706897, 2004, B1. Location in patent: Page column 3-4
[2] Patent: CN108250168, 2018, A. Location in patent: Paragraph 0009-0010; 0011-0012; 0013-0014; 0015-0016
[3] Patent: US6727370, 2004, B1. Location in patent: Page column 4
[4] Patent: US2007/117990, 2007, A1. Location in patent: Page/Page column 12-13

4,4'-Oxydiphthalic anhydride synthesis

7717-76-2
1823-59-2
Synthesis of 4,4'-Oxydiphthalic anhydride from 4-(3,4-dicarboxyphenoxy)benzene-1,2-dicarboxylic acid

4,4'-Oxydiphthalic anhydride Preparation Products And Raw materials

Raw materials

4-Chlorophthalic anhydride 1,2-Dichlorobenzene Potassium carbonate 4-(3,4-dicarboxyphenoxy)benzene-1,2-dicarboxylic acid

Preparation Products

4,4'-Oxydiphthalic anhydride Suppliers

Global Suppliers ( 470)
Supplier Tel Email Country ProdList Advantage
CHINATECH(TIANJIN) CHEMICAL CO.,LTD. 18222205756 sales6@chinatechem.com China 100 58
Manac (SHANGHAI) TRADING CO., LTD 021-32503616 sales@manac-inc.com.cn China 161 60
Liling Chuangli Technology Co. LTD 0534-8101711 13606437406 sales@chuanglichem.com China 49 58
Changzhou Sunlight Pharmaceutical Co., Ltd 519-83131668 15995063688 info@sunlightchem.com China 100 69
Heynova (Shanghai) New Material Technology CO., Ltd 17821102608 zoe@heynovachem.com China 211 58
Chengdu Yuanda chemical co.,ltd 028-85356300 18980937689 chenquanxing@126.com China 161 55
Nantong Root King Import&Export Co.,Ltd 13951333918 visonzou@hotmail.com China 209 58
Shanxi Libolong New Materials Co., Ltd 19135980588 13935924147@163.cn China 17 58
ANHUI LAVOISIER TECHNOLOGY.CO..LTD 19520972426 zhaoyun@polyrocks.com China 526 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
CHINATECH(TIANJIN) CHEMICAL CO.,LTD. 58
Manac (SHANGHAI) TRADING CO., LTD 60
Liling Chuangli Technology Co. LTD 58
Changzhou Sunlight Pharmaceutical Co., Ltd 69
Heynova (Shanghai) New Material Technology CO., Ltd 58
Chengdu Yuanda chemical co.,ltd 55
Nantong Root King Import&Export Co.,Ltd 58
Shanxi Libolong New Materials Co., Ltd 58
ANHUI LAVOISIER TECHNOLOGY.CO..LTD 58
J & K SCIENTIFIC LTD. 76

Related articles

Related Questions

Ask a question
Q:What are the uses of 4,4'-Oxydiphthalic anhydride?jia - Oct 15,2025
A:4,4'-Oxydiphthalic anhydride(ODPA) is primarily used as a key building block for high-performance polymers, particularly in the production of polyimide (PI).Polyimide materials made from ODPA are widely used in many high-tech and industrial fields due to their excellent thermal stability, mechanical strength, and electrical insulation properties.Electronics: This is one of ODPA's most important applications. It is used to manufacture substrates for flexible printed circuits (FPCs), chip packaging, passivation layers, and insulation for wires and cables. For example, the flexible screens and circuits in our mobile phones rely heavily on these high-performance materials.Aerospace: Due to their lightweight and excellent resistance to high temperatures and corrosion, these materials are used in aircraft structural components, engine component coatings, and various composite materials.Separation membrane technology: The unique porous structure of polyimide membranes made from ODPA makes them suitable for gas separation (for example, separating nitrogen from air), water treatment, and pervaporation processes.Other industrial applications: ODPA is also used to manufacture high-temperature-resistant adhesives, coatings, and mechanical parts that must withstand harsh environments.

View Latest Price from 4,4'-Oxydiphthalic anhydride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,4'-Oxydiphthalic anhydride pictures 2026-09-17 4,4'-Oxydiphthalic anhydride
1823-59-2
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
4,4'-Oxydiphthalic anhydride pictures 2026-09-17 4,4'-Oxydiphthalic anhydride
1823-59-2
 $24.00-103.00 1g 0.98 25kg Shanghai UCHEM Inc.
4,4'-Oxydiphthalic anhydride pictures 2026-09-07 4,4'-Oxydiphthalic anhydride
1823-59-2
 1kg 99.8%min 20tons HANGZHOU HAILAN CHEMICAL CO.,LTD.

4,4'-Oxydiphthalic anhydride Spectrum

4,4'-Oxydiphthalic anhydride(1823-59-2)MS4,4'-Oxydiphthalic anhydride(1823-59-2)1HNMR4,4'-Oxydiphthalic anhydride(1823-59-2)13CNMR4,4'-Oxydiphthalic anhydride(1823-59-2)IR14,4'-Oxydiphthalic anhydride(1823-59-2)IR2

1823-59-2 (4,4'-Oxydiphthalic anhydride) Related Search:

Phthaloyl dichloride Isatoic Anhydride Trifluoromethanesulfonic anhydride Caronic anhydride Succinic anhydride
Dibutyl phthalate Glutaric anhydride Phthalamide Phthalimide Phthalic anhydride
Maleic anhydride Phthalates 3-Phenoxybenzaldehyde 5-Methoxy-isobenzofuran-1,3-dione 4-Tolyl ether
3,4'-Dimethyldiphenyl ether Acetic anhydride 3-Phenoxybenzyl alcohol

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4,4'-Oxydiphthalic Anhydride (purified by subliMation) 4,4 '-diphenylether twoanhydride 1,3-Isobenzofurandione, 5,5'-oxybis- Bis-(3-phthalyl anhydride) ether SynonyMs 4,4'-Oxydiphthalic anhydride 4,4''-Oxybisdiphthalic a 5,5'-oxybis(2-benzofuran-1,3-dione) a-ODPA 2,3,3,4'-oxydiphthalic anhydride 4,4'-oxydiphthalic Anhydride in stock Factory 4,4'-Oxydiphthalic anhydride 1823-59-2 Bis-(3-phthalyl anhydride) ether 1823-59-2 Oxydiphthalicanhydride (s-ODPA) 5,5’-oxybis-3-isobenzofurandione oxydiphthalicanhydride 4-4'-OXYDIPHTHALIC ACID ANHYDRIDE 4,4'-OXYDIPHTHALIC ANHYDRIDE 97% 4,4''-OXYBISDIPHTHALIC ANHYDRIDE 5,5'-oxybis-1,3-isobenzofurandione 3,3',4,4'-Diphenylether tetracarboxylic dianhydride 4,4'-Oxybis(1,2-benzenedicarboxylic acid)1,2:1',2'-dianhydride 4,4'-Oxybis(benzene-1,2-dicarboxylic acid)1,2:1',2'-dianhydride 4,4'-Oxybis(phthalic acid)1,2:1',2'-dianhydride 4,4'-Oxybisphthalic 1,2:1',2'-dianhydride 4,4'-Oxybisphthalic acid-1,2:1',2'-dianhydride 4,4'-oxydiphthalic Anhydride（ODPA) 5-(1,3-diketoisobenzofuran-5-yl)oxyisobenzofuran-1,3-quinone 5-[(1,3-dioxo-2-benzofuran-5-yl)oxy]-2-benzofuran-1,3-dione Bis-(3-phthalyl anhy 3,3',4,4'-Diphenyl ether tetracarboxylic aciddianhydride 4,4'-Oxydiphthalic dianhydride (ODPA) 5,5'-Ooxydiisobenzofuran-1,3-dione ODPA 4,4'-oxydiphthalic Anhydride Oxydiphthalic anhydrid Bis-(3-phthalyl anhydride) ether (ODPA) 4,4'-OxydiphthalicAnhydride> OXYDIPHTHALICANHYDRIDE (S-ODPA)CAS 1823-59-2 2-[3-Acetyl-2-methyl-1-(4-methylphenyl)indol-5-yl]oxyethyl-diethylazanium chloride Bis-(3-phthalyl anhydride) ether SynonyMs 4,4'-Oxydiphthalic FFCF FCK 4,4'-Oxydiphthalic anhydride (s-ODPA) 4,4'-Oxydiphthalic anhydride,NA 4,4'-Oxydiphthalic anhydride 3,3',4,4'-Diphenyl ether tetracarboxylic acid dianhydride 3,3'4,4'-Diphenylether tetracarboxylic dianhydride (s-ODPA) 4,4'-OXYDIPHTHALIC ANHYDRIDE 99.5%MIN BIS-(3-PHTHALYL ANHYDRIDE) ETHER 4,4'-Oxydiphthalic Acid 4,4-Oxydiphthalic anhydride 4,4'-Oxydiphthalic dianhydride 5,5'-Oxybis(isobenzofuran-1,3-dione) ODPA s-ODPA 4,4'-Oxydiphthalic anhydride?-1-3 44,4'-Oxydiphthalic anhydride 1823-59-2 1823-58-2 C8H3O32O C16H6O7 Reagent for High-Performance Polymer Research