SJA6017
- CAS No.
- 190274-53-4
- Chemical Name:
- SJA6017
- Synonyms
- SJA6017;TRIA-662-d 3;Calpain-In-4;Calpain Inhibitor 4;CALPAIN INHIBITOR VI;4-FLUORO-BENZENESULFONYL-VAL-L-LEUCINAL;4-FLUORO-BENZENESULFONYL-VAL-LEU-ALDEHYDE;N-(4-FLUOROPHENYLSULFONYL)-L-VALYL-L-LEUCINAL;SJA6017, 4-Fluoro-benzenesulfonyl-Val-L-leucinal;Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde
- CBNumber:
- CB6427018
- Molecular Formula:
- C17H25FN2O4S
- Molecular Weight:
- 372.45
- MDL Number:
- MFCD00954660
- MOL File:
- 190274-53-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.185±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO: 5 mg/ml |
| form | A lyophilized solid |
| pka | 9.04±0.50(Predicted) |
| color | white |
| InChI | 1S/C17H25FN2O4S/c1-11(2)9-14(10-21)19-17(22)16(12(3)4)20-25(23,24)15-7-5-13(18)6-8-15/h5-8,10-12,14,16,20H,9H2,1-4H3,(H,19,22) |
| InChIKey | WSJWUIDLGZAXID-UHFFFAOYSA-N |
| SMILES | Fc1ccc(cc1)[S](=O)(=O)NC(C(C)C)C(=O)NC(CC(C)C)C=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SJA6017 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23942 | Calpain Inhibitor VI ≥95% | 190274-53-4 | 1mg | $81 | 2026-04-30 | Buy |
| Biosynth | FC111099 | Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde | 190274-53-4 | 2mg | $900 | 2026-06-04 | Buy |
| Biosynth | FC111099 | Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde | 190274-53-4 | 1mg | $900 | 2026-06-04 | Buy |
| Biosynth | FC111099 | Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde | 190274-53-4 | 0.5mg | $900 | 2026-06-04 | Buy |
| Biosynth | FC111099 | Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde | 190274-53-4 | 5mg | $1113.7 | 2026-06-04 | Buy |
SJA6017 Chemical Properties, Uses, Production
Description
Calpain inhibitor VI is an inhibitor of the calcium-dependent cysteine proteases μ-calpain (calpain-1; IC50 = 7.5 nM) and m-calpain (calpain-2; IC50 = 78 nM). It also inhibits cathepsins B and L (IC50s = 15 and 1.6 nM, respectively). It is selective for these calpains and cathepsins over other cysteine and serine proteases, factor VIIa, factor Xa, trypsin, chymotrypsin, and proteasome. In an in vitro porcine model of cataract, calpain inhibitor VI decreases the degree of cataract by 40% when used at a concentration of 0.8 μM. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Calpain inhibitor VI improves functional outcome and reduces apoptotic cell death in a rat model of spinal cord injury.
Uses
Calpain Inhibitor VI (SJA6017) is a synthesized peptide aldehyde inhibitor of calpain. Calpain Inhibitor VI inhibits purified m-calpain with the IC50 of 80 nM. Calpain Inhibitor VI can be used for the research of cataract[1].
References
[1] C Fukiage, et al. SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: amelioration of cataract in cultured rat lenses. Biochim Biophys Acta. 1997 Oct 24;1361(3):304-12. DOI:10.1016/s0925-4439(97)00043-4
SJA6017 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Alabiotech Inc. | 001-619-354-5251 | sales@alabiotech-e.com | United States | 972 | 60 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4726 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Alpha Biopharmaceuticals Co., Ltd | 0411-39042497 | sales@alphabiopharm.com | China | 1951 | 58 |
