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Fmoc-D-2-thienylalanine

Fmoc-D-2-thienylalanine Structure
Fmoc-D-2-thienylalanine structure
CAS No.
201532-42-5
Chemical Name:
Fmoc-D-2-thienylalanine
Synonyms
FMOC-D-THI-OH;(R)-N-FMOC-2-THIENYLALANINE;Fmoc-β-(2-thienyl)-D-alanine;FMOC-D-THA;Fmoc-D-2-THI;Fmoc-D-2-Thi-OH;RARECHEM BK PT 0214;FMOC-D-THIENYLALANINE;Fmoc-D-2-thienylalanine;FMOC-D-ALA(2-THIENYL)-OH
CBNumber:
CB6438836
Molecular Formula:
C22H19NO4S
Molecular Weight:
393.46
MDL Number:
MFCD00065677
MOL File:
201532-42-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:54:15
Request For Quotation

Fmoc-D-2-thienylalanine Properties

Melting point 169 °C
Boiling point 623.4±55.0 °C(Predicted)
Density 1.343±0.06 g/cm3 (20 ºC 760 Torr)
refractive index 1.5060 (estimate)
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
pka 3.59±0.10(Predicted)
form solid
color White to off-white
Major Application peptide synthesis
InChI InChI=1/C22H19NO4S/c24-21(25)20(12-14-6-5-11-28-14)23-22(26)27-13-19-17-9-3-1-7-15(17)16-8-2-4-10-18(16)19/h1-11,19-20H,12-13H2,(H,23,26)(H,24,25)/t20-/s3
InChIKey PXBMQFMUHRNKTG-XKGZFIRZNA-N
SMILES C(C1C2=CC=CC=C2C2=CC=CC=C12)OC(=O)N[C@@H](C(=O)O)CC1SC=CC=1 |&1:18,r|
CAS DataBase Reference 201532-42-5(CAS DataBase Reference)
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Safety Statements  24/25
WGK Germany  3
HazardClass  IRRITANT
HS Code  29309090
Storage Class 11 - Combustible Solids

Fmoc-D-2-thienylalanine price More Price(62)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.52238 Fmoc-D-Thi-OH Novabiochem? 201532-42-5 5G $736 2026-04-30 Buy
Sigma-Aldrich CDS003855 Fmoc-D-2-thienylalanine AldrichCPR 250 mg $73.1 2025-07-31 Buy
Sigma-Aldrich CDS003855 Fmoc-D-2-thienylalanine AldrichCPR 201532-42-5 250mg $70.9 2024-03-01 Buy
Usbiological 276942 Fmoc-beta-(2-thienyl)-D-alanine Asreported 201532-42-5 1g $340 2026-06-03 Buy
Usbiological 276942 Fmoc-beta-(2-thienyl)-D-alanine Asreported 201532-42-5 2g $466 2026-06-03 Buy
Product number Packaging Price Buy
8.52238 5G $736 Buy
CDS003855 250 mg $73.1 Buy
CDS003855 250mg $70.9 Buy
276942 1g $340 Buy
276942 2g $466 Buy

Fmoc-D-2-thienylalanine Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

Propanedioic acid, 2-thienyl-, diethyl ester

88798-28-1

N-(9-Fluorenylmethoxycarbonyloxy)succinimide

82911-69-1

FMOC-D-2-THIENYLALANINE

201532-42-5

2.3 Diethyl 2-thienylmalonate was used as the starting material, and the saponification reaction was first carried out with 2.3 equivalents of aqueous sodium hydroxide. Subsequently, L-acylase, 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu) and acetone were added, and the pH of the reaction system was adjusted to 8-9 with aqueous sodium carbonate.After completion of the reaction, Fmoc-Thi-OH was isolated (stored separately), and the mother liquor was frozen and stored.2.4 About 2 L of the above mother liquor was transferred to a 5 L three-necked flask, and 1 L of a mixture of hydrochloric acid and methanol mixture. The reaction mixture was heated to reflux for 60 hours. The reaction was monitored by nuclear magnetic resonance (NMR) and thin layer chromatography (TLC). When the reaction was essentially complete, the Fmoc-OSu solid was removed by filtration and the reaction process continued to be followed by TLC. After the reaction was complete, the reaction system was washed four times with 500 mL of a solvent mixture of ethyl acetate and petroleum ether. Subsequently, the reaction system was acidified with hydrochloric acid to a pH of about 1. Cooling and stirring resulted in 48 g of brown crystalline product.

References

[1] Patent: CN106565665, 2017, A. Location in patent: Paragraph 0016-0018; 0021-0023; 0026-0027; 0030-0031; 0038

Fmoc-D-2-thienylalanine Preparation Products And Raw materials

Raw materials

Propanedioic acid, 2-thienyl-, diethyl ester Fmoc-OSu Water Methanol Sodium hydroxide
Hydrochloric acid

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Preparation Products

Fmoc-D-2-thienylalanine Suppliers

Global( 140)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Shanghai HC Biotech Co., Ltd 021-20227858 sale@hcbiotech.com.cn China 1173 55
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Suzhou haiyu Biochem Industrial Co., LTD 512-68097639 18013585858 744942877@qq.com China 915 62
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
RYSS TECH LTD 400-188-0725 +86 21 34310725 13611771617 China 1999 57
Shenzhen Sungening Bio-Tech Co., Ltd +86-0755-89668383 sales@sungening.com China 1319 65
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Shanghai HC Biotech Co., Ltd 55
Wuhan Chemwish Technology Co., Ltd 56
Suzhou haiyu Biochem Industrial Co., LTD 62
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60
China DongFan Chemical Co.,LTD 66
RYSS TECH LTD 57
Shenzhen Sungening Bio-Tech Co., Ltd 65

View Lastest Price from Fmoc-D-2-thienylalanine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fmoc-β-(2-thienyl)-D-alanine pictures 2026-08-25 Fmoc-β-(2-thienyl)-D-alanine
201532-42-5
 $3.00-9.00 99% ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
FMOC-D-2-THIENYLALANINE pictures 2019-07-06 FMOC-D-2-THIENYLALANINE
201532-42-5
 $1.00 1KG 99% 20kg Career Henan Chemical Co

201532-42-5(Fmoc-D-2-thienylalanine)Related Search:

Fmoc-D-Trp(Boc)-OH D-2-Thienylalanine beta-(2-Thienyl)-DL-alanine 3-(2-Thienyl)propionic acid (S)-N-FMOC-2-Thienylalanine
3-(2-Thienyl)-1-propanol 2-Thiophenemethylamine FMOC-D-alanine Fmoc-D-Abu-OH Fmoc-D-2-(5-bromothienyl)alanine
1-Methyl-2-thiophen-2-yl-ethylamine Methyl-(2-thiophen-2-yl-ethyl)-amine Fmoc-D-Ala-aldehyde Fmoc-3-(2-thienyl)-DL-alanine Fmoc-3-(3-thienyl)-DL-alanine
Fmoc-D-3-thienylalanine Fmoc-D-2-thienylalanine FMOC-L-3-THIENYLALANINE

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FMOC-3-(2-THIENYL)-D-ALANINE FMOC-D-ALA(2-THIENYL)-OH FMOC-D-THA FMOC-D-THIENYLALANINE Fmoc-D-2-Thi-OH Fmoc-D-3-(2-Thienyl)-alanine Fmoc-D-3-(2-Thienyl)-L-alanine (R)-N-fmoc-2-Thienylalanine(e.e.) 3-Thien-2-yl-D-alanine, N-FMOC protected (R)-N-Fmoc-2-thienylalanine, 95%, ee:98% (R)-N-FMOC-2-Thienylalanine, 98% ee (αR)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-thiophenepropanoic acid Fmoc-D-2-THI (2R)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-thiophen-2-ylpropanoate (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(thiophen-2-yl)propanoic acid (R)-N-FMOC-2-Thienylalanine,95%,98% ee FMoc-b-(2-thienyl)-D-Ala-OH (R)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]-3-(thiophen-2-yl)propanoic acid Fmoc-β-(2-thienyl)-D-alanine≥ 98% (HPLC) Fmoc-D-Thi-OH Novabiochem N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-(2-THIENYL)-D-ALANINE N-(9-FLUORENYLMETHOXYCARBONYL)-2-THIENYL-D-ALANINE N-ALPHA-FMOC-BETA-THIENYL-D-ALANINE RARECHEM BK PT 0214 FMOC-3-D-ALA(2-THIENYL)-OH FMOC-BETA-(2-THIENYL)-D-ALANINE FMOC-BETA-(2-THIENYL)-D-ALA-OH FMOC-D-THI-OH (FMOC-D-3-(2-THIENYL)-ALANINE) (9H-Fluoren-9-yl)MethOxy]Carbonyl β-(2-thienyl)-D-Alanine N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-3-(thien-2-yl)-D-alanine, (2R)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(thien-2-yl)propanoic acid FMoc-β-(2-thienyl)-D-alanine, ee: 98% 2-Thiophenepropanoic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (αR)- FMOC-D-2-THIENYLALANINE USP/EP/BP (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-thiophen-2-ylpropanoate Fmoc-3-(2-thienyl)-D-Ala-OH N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-(thiophen-2-yl)-D-alanine (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid - [F90760] (R)-N-FMOC-2-THIENYLALANINE FMOC-D-THI-OH Fmoc-β-(2-thienyl)-D-alanine Fmoc-D-Thi-OH Fmoc-β-(2-thienyl)-D-Alanine Fmoc-D-2-thienylalanine 201532-42-5 C22HNO4S C22H18NO4S Phenylalanine analogs and other aromatic alpha amino acids Amino Acid Derivatives a-amino Amino Acids