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3-Chloro-5-methoxypyridazine

3-Chloro-5-methoxypyridazine Structure
3-Chloro-5-methoxypyridazine structure
CAS No.
123696-02-6
Chemical Name:
3-Chloro-5-methoxypyridazine
Synonyms
3-Chloro-5-methoxypyridazine;Pyridazine, 3-chloro-5-methoxy-;3-Chloro-5-Methoxypyridazine HCl;3-Chloro-5-methoxypyridazine, HCl salt;3-CHLORO-5-METHOXYPYRIDAZINE ISO 9001：2015 REACH
CBNumber:
CB6444316
Molecular Formula:
C5H5ClN2O
Molecular Weight:
144.56
MDL Number:
MFCD08236839
MOL File:
123696-02-6.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:15
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3-Chloro-5-methoxypyridazine Properties

Boiling point 285 ºC
Density 1.292
Flash point 126 ºC
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 2.45±0.10(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C5H5ClN2O/c1-9-4-2-5(6)8-7-3-4/h2-3H,1H3
InChIKey XLGRINRFBNCHQS-UHFFFAOYSA-N
SMILES C1(Cl)=NN=CC(OC)=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933998090

3-Chloro-5-methoxypyridazine price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 269636 3-Chloro-5-methoxypyridazine Asreported 123696-02-6 1g $785 2026-06-03 Buy
Usbiological 269636 3-Chloro-5-methoxypyridazine Asreported 123696-02-6 2g $1253 2026-06-03 Buy
Usbiological 269636 3-Chloro-5-methoxypyridazine Asreported 123696-02-6 5g $2018 2026-06-03 Buy
Usbiological 269636 3-Chloro-5-methoxypyridazine Asreported 123696-02-6 10g $3150 2026-06-03 Buy
Usbiological 269636 3-Chloro-5-methoxypyridazine Asreported 123696-02-6 25g $6265 2026-06-03 Buy
Product number Packaging Price Buy
269636 1g $785 Buy
269636 2g $1253 Buy
269636 5g $2018 Buy
269636 10g $3150 Buy
269636 25g $6265 Buy

3-Chloro-5-methoxypyridazine Chemical Properties, Uses, Production

Uses

3-Chloro-5-methoxypyridazine is used to synthesize potent and selective inhibitors of glycogen synthase kinase 3 with good cellular efficacy.

Synthesis

5-METHOXYPYRIDAZIN-3(2H)-ONE

123696-01-5

3-CHLORO-5-METHOXYPYRIDAZINE

123696-02-6

5-Methoxypyridazin-3(2H)-one (250 mg, 1.98 mmol) was used as starting material and suspended in phosphoryl chloride (1.5 mL, 16 mmol). The reaction mixture was stirred at 100 °C for 10 min. After completion of the reaction, the mixture was slowly poured into ice water and the pH was adjusted to alkaline by adding sodium carbonate. Subsequently, the mixture was extracted with ether and the organic phases were combined and dried with anhydrous magnesium sulfate. After filtration, the solvent was removed by distillation under reduced pressure. The resulting residue was recrystallized with 1,2-dichloroethane to give 130 mg of 3-chloro-5-methoxypyridazine in 45% yield. The product was analyzed by LC-MS (Method 5): r = 0.85 mm; MS (ESIpos): m/z = 145 [M + H]+. 1H-NMR (400 MHz, DMSO-d6) δ (ppm): 2.495 (0.78), 2.499 (1.07), 2.503 (0.84), 3.317 (11.94). 3.944 (16.00), 7.528 (2.28), 7.534 (2.29), 8.988 (2.34), 8.994 (2.34).

References

[1] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 5, p. 1473 - 1476
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 19, p. 4716 - 4730
[3] Monatshefte fuer Chemie, 1989, vol. 120, p. 329 - 342
[4] Patent: WO2017/102091, 2017, A1. Location in patent: Page/Page column 455; 456

3-Chloro-5-methoxypyridazine synthesis

124-41-4
1837-55-4
123696-02-6
Synthesis of 3-Chloro-5-methoxypyridazine from Sodium Methoxide and 3,5-Dichloropyridazine

3-Chloro-5-methoxypyridazine Preparation Products And Raw materials

Raw materials

3(2H)-Pyridazinone, 5-methoxy-2-(tetrahydro-2H-pyran-2-yl)- 3(2H)-Pyridazinone, 4-bromo-5-methoxy- 4-Chloro-5-methoxy-2-(2-tetrahydropyranyl)pyridazin-3(2H)-one 3,5-Dichloropyridazine 5-Methoxypyridazin-3(2H)-one
4-Chloro-5-methoxypyridazin-3(2H)-one Water Methanol Sodium Methoxide

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Preparation Products

3,5-diMethoxypyridazine ethyl 5-methoxypyridazine-3-carboxylate 4-Methoxypyridazine

3-Chloro-5-methoxypyridazine Suppliers

Global Suppliers ( 126)
Supplier Tel Email Country ProdList Advantage
Jinan HM Medical Technology Co., Ltd. 0531-88262980 13156180564 jnhengmao@163.com China 100 62
Jiangxi Kaixin Biomedical Co., Ltd. 0797-2111676 18890136722 sales@chiralsyn.com China 106 58
Nanbu County Chengxin Technology Co., Ltd. 0838-5675166 15883665058 nbcxkj@126.com China 956 55
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 sales@sun-shinechem.com China 1197 64
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
SpringPharma Tech Co.,Ltd +86-25-68710855, +86-25-68710897 sales@springpharma.net China 1260 62
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Supplier Advantage
Jinan HM Medical Technology Co., Ltd. 62
Jiangxi Kaixin Biomedical Co., Ltd. 58
Nanbu County Chengxin Technology Co., Ltd. 55
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Jia Xing Isenchem Co.,Ltd 66
Tetranov Biopharm 64
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
Jinan Trio PharmaTech Co., Ltd. 62
SpringPharma Tech Co.,Ltd 62
Shanghai Topbiochem Technology Co., Ltd 58

View Latest Price from 3-Chloro-5-methoxypyridazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-CHLORO-5-METHOXYPYRIDAZINE pictures 2026-08-20 3-CHLORO-5-METHOXYPYRIDAZINE
123696-02-6
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
3-CHLORO-5-METHOXYPYRIDAZINE pictures 2025-04-04 3-CHLORO-5-METHOXYPYRIDAZINE
123696-02-6
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
3-Chloro-5-methoxypyridazine pictures 2022-04-22 3-Chloro-5-methoxypyridazine
123696-02-6
 98%min 50kgs/month Shanghai Rlavie Technology Co ltd

3-Chloro-5-methoxypyridazine Spectrum

3-CHLORO-5-METHOXYPYRIDAZINE(123696-02-6)1HNMR

123696-02-6 (3-Chloro-5-methoxypyridazine) Related Search:

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3-Chloro-5-methoxypyridazine, HCl salt 3-Chloro-5-Methoxypyridazine HCl Pyridazine, 3-chloro-5-methoxy- 3-CHLORO-5-METHOXYPYRIDAZINE ISO 9001：2015 REACH 3-Chloro-5-methoxypyridazine 123696-02-6