BERTEROIN
- CAS No.
- 4430-42-6
- Chemical Name:
- BERTEROIN
- Synonyms
- KB47947;LP088984;KB-47947;LP-088984;BERTEROIN;OR-009512;1-isothiocyanato-5-(methylthio)pentane;5-(methylsulfanyl)pentyl isothiocyanate;1-isothiocyanato-5-methylsulfanylpentane;1-isothiocyanato-5-methylsulfanyl-pentane
- CBNumber:
- CB6445272
- Molecular Formula:
- C7H13NS2
- Molecular Weight:
- 175.31
- MDL Number:
- MFCD00210791
- MOL File:
- 4430-42-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 155~156℃ |
|---|---|
| Boiling point | 155 °C(Press: 10 Torr) |
| Density | 1.01±0.1 g/cm3(Predicted) |
| FEMA | 4416 | 5-(METHYLTHIO)PENTYL ISOTHIOCYANATE |
| storage temp. | Store at -20°C |
| solubility | DMF: 3 mg/ml; DMSO: 16 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml |
| Odor | at 0.01 % in propylene glycol. cabbage radish |
| Odor Type | radish |
| JECFA Number | 1896 |
| LogP | 2.67 |
| Substances Added to Food (formerly EAFUS) | 5-(METHYLTHIO)PENTYL ISOTHIOCYANATE |
| FDA UNII | 0L0K74BW6T |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
BERTEROIN price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17880 | Berteroin ≥95% | 4430-42-6 | 5mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 17880 | Berteroin ≥95% | 4430-42-6 | 10mg | $72 | 2026-04-30 | Buy |
| Cayman Chemical | 17880 | Berteroin ≥95% | 4430-42-6 | 25mg | $157 | 2026-04-30 | Buy |
| Cayman Chemical | 17880 | Berteroin ≥95% | 4430-42-6 | 50mg | $274 | 2026-04-30 | Buy |
| ChemScene | CS-0079418 | Berteroin | 4430-42-6 | 5mg | $93 | 2026-06-04 | Buy |
BERTEROIN Chemical Properties, Uses, Production
Description
Berteroin is a sulforaphane analog found in cruciferous vegetables including Chinese cabbage, rucola salad leaves, and mustard oil. At 1.7 μM, it has been shown to double the phase II enzyme quinone reductase activity in mouse hepatoma cells. Berteroin exerts anti-inflammatory activity in LPS-stimulated RAW 264.7 macrophages, inhibiting degradation of IκBα, as well as NF-κB p65 translocation to the nucleus and DNA binding activity. It also suppresses IRAK degradation and phosphorylation of TAK1, p38 MAPK, ERK1/2, and Akt.
Chemical Properties
Pale yellow liquid; penetrating radish-like aroma
Occurrence
Reported found in radish and horseradish.
Uses
Berteroin is a compound with high odor potency occurring in horseradish ( Armoracia rusticana)
Definition
ChEBI: Berteroin is an isothiocyanate.
Aroma threshold values
High strength odor; recommend smelling in a 0.01% solution or less.
Enzyme inhibitor
This sulforaphane analogue and antimetastatic agent (FW = 175.43 g/mol; CAS 4430-42-6; Physical State = Liquid; Soluble in ethanol, DMSO, and chloroform; Store at -20° C; M.P. = 155-156° C), also named 5- methylthiopentyl isothiocyanate, is found in cruciferous vegetables (including Chinese cabbage and rucola leaves) and mustard oil. Berteroin inhibits LPS-induced degradation of Inhibitor of κBα (or IκBα) as well as NF-κB p65 translocation into the nucleus and DNA binding. Berteroin also suppresses degradation of IL-1 Receptor Associated Kinase and phosphorylation of Transforming Growth Factor β-Activated Kinase-1. Berteroin also inhibits LPS-induced phosphorylation of p38 MAPK, ERK1/2, and AKT
References
[1] YOO JIN JUNG. Berteroin present in cruciferous vegetables exerts potent anti-inflammatory properties in murine macrophages and mouse skin.[J]. International Journal of Molecular Sciences, 2014, 15 11: 20686-20705. DOI: 10.3390/ijms151120686
[2] Y ZHANG. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1992, 89 6: 2399-2403. DOI: 10.1073/pnas.89.6.2399
BERTEROIN Preparation Products And Raw materials
BERTEROIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Shanghai wencai New Material Technology Co., Ltd. | 15721586846 | wencaimat@163.com | China | 2792 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 9995 | 58 |
