ChemicalBook >> CAS DataBase List >>1,2,2,6,6-Pentamethyl-4-piperidinol

1,2,2,6,6-Pentamethyl-4-piperidinol

1,2,2,6,6-Pentamethyl-4-piperidinol structure

CAS No.: 2403-89-6

Chemical Name:: 1,2,2,6,6-Pentamethyl-4-piperidinol

Synonyms: Pentamethylpiperidinol;1,2,2,6,6-Pentamethylpiperidin-4-ol;HOPEMP;NSC 364075;METHYL-TAA-OL;Pentamethylpyridinol;1,2,2,6,6-Pentamethy;5-MethylpiperidineAlcohol;1,2,2,6,6-Pentamethyl-4-piperi;N-Methyltriacetoneaminoalcohol

CBNumber:: CB6457693

Molecular Formula:: C10H21NO

Molecular Weight:: 171.28

MDL Number:: MFCD00191220

MOL File:: 2403-89-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-19 22:55:08

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1,2,2,6,6-Pentamethyl-4-piperidinol Properties

Melting point	72-76 °C
Boiling point	238 °C
Density	0.967
vapor pressure	0.845Pa at 25℃
refractive index	1.4621 (estimate)
Flash point	118 °C
storage temp.	Sealed in dry,Room Temperature
form	Flakes
pka	14.93±0.60(Predicted)
color	Light yellow
Water Solubility	4.8 g/100 mL (20 ºc)
BRN	1498
InChI	1S/C10H21NO/c1-9(2)6-8(12)7-10(3,4)11(9)5/h8,12H,6-7H2,1-5H3
InChIKey	NWHNXXMYEICZAT-UHFFFAOYSA-N
SMILES	CN1C(C)(C)CC(O)CC1(C)C
LogP	1.15 at 25℃
CAS DataBase Reference	2403-89-6(CAS DataBase Reference)
FDA UNII	LR520BAM5V
EPA Substance Registry System	4-Piperidinol, 1,2,2,6,6-pentamethyl- (2403-89-6)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07,GHS09

Signal word

Danger

Hazard statements

H302-H314-H317-H411

Precautionary statements

P260-P273-P280-P301+P312-P303+P361+P353-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes

Xi,C,N,Xn

Risk Statements

43-34-22-51/53

Safety Statements

36/37-45-36/37/39-26-61

RIDADR

UN3261 - class 8 - PG 1 - EHS - Corrosive solid, acidic, organic, n.o.s., HI: all

WGK Germany

TSCA

TSCA listed

HS Code

29333990

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Chronic 2
Skin Corr. 1A
Skin Sens. 1

REACH Registrations

Active

NFPA 704

	0
3		0

1,2,2,6,6-Pentamethyl-4-piperidinol price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	H1068	4-Hydroxy-1,2,2,6,6-pentamethylpiperidine >98.0%(GC)	2403-89-6	500g	$167	2026-04-30	Buy
TCI Chemical	H1068	4-Hydroxy-1,2,2,6,6-pentamethylpiperidine >98.0%(GC)	2403-89-6	25g	$23	2026-04-30	Buy
Usbiological	158679	1,2,2,6,6-Pentamethyl-4-piperidinol	2403-89-6	10g	$403	2026-06-03	Buy
Apolloscientific	OR929421	1,2,2,6,6-Pentamethyl-4-piperidinol 99%	2403-89-6	100g	$26	2026-06-04	Buy
Apolloscientific	OR929421	1,2,2,6,6-Pentamethyl-4-piperidinol 99%	2403-89-6	500g	$56	2026-06-04	Buy

Product number	Packaging	Price	Buy
H1068	500g	$167	Buy
H1068	25g	$23	Buy
158679	10g	$403	Buy
OR929421	100g	$26	Buy
OR929421	500g	$56	Buy

1,2,2,6,6-Pentamethyl-4-piperidinol Chemical Properties, Uses, Production

Chemical Properties

LIGHT YELLOW FLAKES

Uses

Reactant for: Synthesis of photostable blue emitting naphthalimides1 Synthesis of blue fluorescent naphthalimide pH chemosensors2 Synthesis of crowded piperidines with intramolecularly hydrogen-bonded nitrogen3 Synthesis of spiropyrans and spirooxazines4 Amine photoredox reactions5

Uses

1,2,2,6,6-Pentamethyl-4-piperidinol is used in the synthesis of PDGFR kinase inhibitors. Also, it can be applied to the preparation of a new diol-functionalized amine light stabilizer.

Uses

Reactant for:
Synthesis of photostable blue emitting naphthalimides
Synthesis of blue fluorescent naphthalimide pH chemosensors
Synthesis of crowded piperidines with intramolecularly hydrogen-bonded nitrogen
Synthesis of spiropyrans and spirooxazines
Amine photoredox reactions

Flammability and Explosibility

Non flammable

Synthesis

1,2,2,6,6-pentamethylpiperidinol was synthesized by reductive methylation reaction using 2,2,6,6-tetramethylpiperidinol, paraformaldehyde and formic acid as the raw materials and water as the solvent, and the structure of the product was characterized by nuclear magnetic resonance (NMR) hydrogen spectroscopy, carbon spectroscopy and infrared spectroscopy. The results of one-way and orthogonal experiments showed that the molar ratio of raw materials had the greatest influence on the reductive methylation reaction, followed by the reaction temperature and finally the reaction time. The suitable conditions for this reductive methylation reaction were: n (tetramethylpiperidinol): n (paraformaldehyde): n (formic acid) = 1:1.05:1.05, reaction temperature of 80 C, reaction time of 2.5 h, and the solvent water could be applied three times. Under this optimized condition, the average yield of pentamethylpiperidinol was 97.9% and the purity was 99.6%.

Toxics Screening Level

The initial threshold screening level (ITSL) for 1,2,2,6,6-pentamethyl-4-piperidinol is 0.1 μg/m3 based on annual averaging time.

1,2,2,6,6-Pentamethyl-4-piperidinol Preparation Products And Raw materials

Raw materials

Preparation Products

2,2,6,6-Tetramethyl-4-piperidinol 1 2 2 6 6-Pentamethyl-4-piperidone 97 Sanol LS 540

1,2,2,6,6-Pentamethyl-4-piperidinol Suppliers

Global Suppliers ( 242)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Hike Biological Technology.,ltd	025-52110956 17372769668	sophia@njhkchem.com	China	35	58
Tianjin Zhongxin Chemtech Co., Ltd.	022-66880623	sales@tjzxchem.com	China	612	60
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6742	52
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
Tianjin heowns Biochemical Technology Co., Ltd.	400 638 7771	sales@heowns.com	China	14412	57
Beijing Taiya Jie Technology Development Co., Ltd.	021-33690831-8001 13552411790;18616022633	postmaster@tyjchem.cn	China	1541	55

Supplier	Advantage
Nanjing Hike Biological Technology.,ltd	58
Tianjin Zhongxin Chemtech Co., Ltd.	60
J & K SCIENTIFIC LTD.	76
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Shanghai Hanhong Scientific Co.,Ltd.	64
XiaoGan ShenYuan ChemPharm co,ltd	52
Syntechem Co.,Ltd	57
Tianjin heowns Biochemical Technology Co., Ltd.	57
Beijing Taiya Jie Technology Development Co., Ltd.	55

View Latest Price from 1,2,2,6,6-Pentamethyl-4-piperidinol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	1,2,2,6,6-Pentamethyl-4-piperidinol 2403-89-6	$10.00	1kg	99%	20tons	Nantong Provichem Biotech Co., Ltd.
2026-09-07	1,2,2,6,6-Pentamethyl-4-piperidinol 2403-89-6		1kg	99%min	20tons	HANGZHOU HAILAN CHEMICAL CO.,LTD.
2026-08-25	1,2,2,6,6-Pentamethyl-4-piperidinol 2403-89-6	$2.20-8.80	1kg	99%min	1000kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

1,2,2,6,6-Pentamethyl-4-piperidinol
2403-89-6
$10.00
99%
Nantong Provichem Biotech Co., Ltd.

1,2,2,6,6-Pentamethyl-4-piperidinol
2403-89-6
$0.00
99%min
HANGZHOU HAILAN CHEMICAL CO.,LTD.

1,2,2,6,6-Pentamethyl-4-piperidinol
2403-89-6
$2.20-8.80
99%min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

1,2,2,6,6-Pentamethyl-4-piperidinol Spectrum

1,2,2,6,6-Pentamethyl-4-piperidinol(2403-89-6)¹HNMR

2403-89-6 (1,2,2,6,6-Pentamethyl-4-piperidinol) Related Search:

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4-(Aminomethyl)piperidine 2,6-Dimethylpiperidine Triacetonediamine Methylparaben Kresoxim-methyl

Methyl acrylate Methyl acetate Thiophanate-methyl 2,2,6,6-Tetramethyl-4-piperidinol 2,2,6,6-Tetramethylpiperidine

Metsulfuron methyl 4-Hydroxy-TEMPO N-Methylpiperidine

1of4

1,2,2,6,6-pentamethyl-4-piperidino 1,2,2,6,6-PENTAMETHYL-4-PIPERIDINOL 1,2,2,6,6-PENTAMETHYL-4-HYDROXYPIPERIDINE METHYL-TAA-OL N-METHYL-2,2,6,6-TETRAMETHYL-4-PIPERIDINOL N-METHYL-TRIACETONAMINO ALCOHOL N-Methyltriacetoneaminoalcohol 1,2,2,6,6-PENTAMETHYL-4-PIPERIDINOL 99+% 1,2,2,6,6-Pentamethyl-4-Piperidol 1,2,2,6,6-Pentamethyl-4-piperi 4-Piperidinol, 1,2,2,6,6-pentamethyl- 4-HYDROXY-1,2,2,6,6-PENTAMETHYLPIPERIDINE NSC 364075 N-Methyl Triacetonamino Alcohol Methyl-TAA-ol HOPEMP 1,2,2,6,6-pentamethyl-4-piperidin-1-iumol 4-Hydroxy-1,2,2,6,6-pentamethylpiperidine> N-Methyl-2,2,6,6-tetramethyl-4-piperidinol 1,2,2,6,6,-Pentamethyl-4-piperidinol PAAOL 1,2,2,6,6-PENTAMETHYL-4-HYChemicalbookDROXYPIPERIDINE Pentamethylpyridinol 5-MethylpiperidineAlcohol 1,2,2,6,6-pentamethylpiperidinol 1,2,2,6,6-Pentamethy 1,2,2,6,6-Pentamethylpiperidin-4-ol Pentamethylpiperidinol 2403-89-6 C10H22NO C10H21NO Piperidines Heterocyclic Building Blocks Building Blocks Piperidines Building Blocks C10 Chemical Synthesis Heterocyclic Building Blocks Industrial/Fine Chemicals API intermediates