3,4-Dihydroxybenzonitrile
- CAS No.
- 17345-61-8
- Chemical Name:
- 3,4-Dihydroxybenzonitrile
- Synonyms
- AKOS B004053;4-CYANOCATECHOL;TIMTEC-BB SBB008582;Protocatechunitrile;4-CYANOPYROCATECHOL;3,4-Dihydroxybenzoni;Protocatachuonitrile;PROTOCATECHUONITRILE;Thymol Impurity 14-d8;3,4-DihydroxybenzonitriL
- CBNumber:
- CB6496926
- Molecular Formula:
- C7H5NO2
- Molecular Weight:
- 135.12
- MDL Number:
- MFCD00016436
- MOL File:
- 17345-61-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3,4-Dihydroxybenzonitrile 97% | 538396 | 25g | $156 |
| 3,4-Dihydroxybenzonitrile >98.0%(GC) | D3352 | 5g | $33 |
| 3,4-Dihydroxybenzonitrile >98.0%(GC) | D3352 | 25g | $135 |
| 3,4-Dihydroxybenzonitrile 99+% (HPLC) ≥99%(HPLC) | 232247 | 1g | $156 |
| 3,4-Dihydroxybenzonitrile 99+% (HPLC) ≥99%(HPLC) | 232247 | 5g | $170 |
| More product size | |||
| Melting point | 155-159 °C (lit.) |
|---|---|
| Boiling point | 334.8±32.0 °C(Predicted) |
| Density | 1.42±0.1 g/cm3(Predicted) |
| vapor pressure | 0Pa at 20℃ |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 7.67±0.18(Predicted) |
| color | White to Almost white |
| Water Solubility | insoluble |
| BRN | 2082204 |
| InChI | InChI=1S/C7H5NO2/c8-4-5-1-2-6(9)7(10)3-5/h1-3,9-10H |
| InChIKey | NUWHYWYSMAPBHK-UHFFFAOYSA-N |
| SMILES | C(#N)C1=CC=C(O)C(O)=C1 |
| LogP | 1.3 at 20℃ |
| CAS DataBase Reference | 17345-61-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H302-H312-H331-H335 | |||||||||
| Precautionary statements | P261-P304+P340-P305+P351+P338-P501a-P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 36/37-36/37/39-26-22 | |||||||||
| RIDADR | UN3439 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29269090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
3,4-Dihydroxybenzonitrile price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 538396 | 3,4-Dihydroxybenzonitrile 97% | 17345-61-8 | 25g | $156 | 2026-04-30 | Buy |
| TCI Chemical | D3352 | 3,4-Dihydroxybenzonitrile >98.0%(GC) | 17345-61-8 | 5g | $33 | 2026-04-30 | Buy |
| TCI Chemical | D3352 | 3,4-Dihydroxybenzonitrile >98.0%(GC) | 17345-61-8 | 25g | $135 | 2026-04-30 | Buy |
| Usbiological | 232247 | 3,4-Dihydroxybenzonitrile 99+% (HPLC) ≥99%(HPLC) | 17345-61-8 | 1g | $156 | 2026-06-03 | Buy |
| Usbiological | 232247 | 3,4-Dihydroxybenzonitrile 99+% (HPLC) ≥99%(HPLC) | 17345-61-8 | 5g | $170 | 2026-06-03 | Buy |
3,4-Dihydroxybenzonitrile Chemical Properties,Uses,Production
Chemical Properties
Off-white powder
Uses
3,4-Dihydroxybenzonitrile is mainly used to synthesize drugs containing thiazole, 2-oxazoline, imidazole, triazole and benzopyrimidine structures, such as quinazoline drugs for anticancer. In recent years, in the field of new materials, 3,4-dihydroxybenzonitrile has also been used in the synthesis of photosensitive materials.
General Description
3,4-Dihydroxybenzonitrile can be prepared from 4-hydroxy-3-methoxybenzonitrile. It can also be synthesized by reacting 3,4-dimethoxybenzonitrile, lithium diisopropylamide (LDA) and 1,3-dimethyl-2-imidazolidinone (DMEU).
Synthesis
3-Methoxy-4-hydroxybenzaldehyde (vanillin) was used as the raw material, and 3-methoxy-4-hydroxybenzonitrile was obtained by reaction with hydroxylamine hydrochloride, and then 3,4-Dihydroxybenzonitrile was synthesized by demethylation reaction with alkali metal halide. The product content was 99.8%, and the total yield based on vanillin was 75.2%.
3,4-Dihydroxybenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huanfu Industrial Co.，（Shanghai）Ltd. | +86-18001856580 | 2415195517@qq.com | China | 43 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8737 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14036 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3004 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6339 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Jinan Honest Pharm Co., Ltd | zpy8217@163.com | China | 286 | 58 |
View Lastest Price from 3,4-Dihydroxybenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-03 | 3,4-Dihydroxybenzonitrile
17345-61-8
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-03-20 | 3,4-Dihydroxybenzonitrile
17345-61-8
|
$8.00-10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-03-12 | Apremilast Impurity 60
17345-61-8
|
10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD |
-
- 3,4-Dihydroxybenzonitrile
17345-61-8
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3,4-Dihydroxybenzonitrile
17345-61-8
- $8.00-10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Apremilast Impurity 60
17345-61-8
- $0.00
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
